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- Paillet, J, et al.
(author)
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Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
- 2021
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 1540-9538 .- 0022-1007. ; 218:10
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Journal article (peer-reviewed)abstract
- Cholangiocarcinoma (CCA) results from the malignant transformation of cholangiocytes. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are chronic diseases in which cholangiocytes are primarily damaged. Although PSC is an inflammatory condition predisposing to CCA, CCA is almost never found in the autoimmune context of PBC. Here, we hypothesized that PBC might favor CCA immunosurveillance. In preclinical murine models of cholangitis challenged with syngeneic CCA, PBC (but not PSC) reduced the frequency of CCA development and delayed tumor growth kinetics. This PBC-related effect appeared specific to CCA as it was not observed against other cancers, including hepatocellular carcinoma. The protective effect of PBC was relying on type 1 and type 2 T cell responses and, to a lesser extent, on B cells. Single-cell TCR/RNA sequencing revealed the existence of TCR clonotypes shared between the liver and CCA tumor of a PBC host. Altogether, these results evidence a mechanistic overlapping between autoimmunity and cancer immunosurveillance in the biliary tract.
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- Eide, A. J., et al.
(author)
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Radial-basis-function networks
- 2016
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In: Intelligent Systems. - : CRC Press. - 9781439802847 - 9781138071889
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Book chapter (other academic/artistic)
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6. |
- Jouault, B., et al.
(author)
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Josephson Coupling in Junctions Made of Monolayer Graphene Grown on SiC
- 2016
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In: Journal of Superconductivity and Novel Magnetism. - : Springer Science and Business Media LLC. - 1557-1947 .- 1557-1939. ; 29:5, s. 1145-1150
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Journal article (peer-reviewed)abstract
- Chemical vapor deposition has proved to be successful in producing graphene samples on silicon carbide (SiC) homogeneous at the centimeter scale in terms of Hall conductance quantization. Here, we report on the realization of co-planar diffusive Al/ monolayer graphene/ Al junctions on the same graphene sheet, with separations between the electrodes down to 200 nm. Robust Josephson coupling has been measured for separations not larger than 300 nm. Transport properties are reproducible on different junctions and indicate that graphene on SiC substrates is a concrete candidate to provide scalability of hybrid Josephson graphene/superconductor devices.
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