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- Kehoe, Laura, et al.
(author)
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Make EU trade with Brazil sustainable
- 2019
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Journal article (other academic/artistic)
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| 3. |
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- 2019
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Journal article (peer-reviewed)
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| 4. |
- Andersson, Magnus, et al.
(author)
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Fiskbestånd och miljö i hav och sötvatten : Resurs- och miljööversikt 2012
- 2012
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Reports (other academic/artistic)abstract
- Detta är den nionde utgåvan av den samlade översikten över fisk- och kräftdjursbeståndens status i våra vatten. Kunskap om fiskbestånden och miljön är en förutsättning för att utnyttjandet av fiskresurserna skall bli bärkraftigt. För svenska vattenområden beskrivs miljöutvecklingen i ett ekosystemsperspektiv, dels för att tydliggöra fiskens ekologiska roll och beskriva yttre miljöfaktorer som påverkar fiskbestånden, dels för att belysa fiskets effekter på miljön.Fiskbestånd och miljö i hav och sötvatten är utarbetad av Sveriges lantbruksuniversitet (SLU), Institutionen för akvatiska resurser (SLU Aqua), på uppdrag av Havs- och vattenmyndigheten. Rapporten sammanfattar utveckling och beståndsstatus för de kommersiellt viktigaste fisk- och kräftdjursarterna i våra vatten. Bedömningar och förvaltningsråd är baserade på Internationella Havsforskningsrådets (ICES) rådgivning, SLU Aquas nationella och regionala provfiskedata, samt yrkesfiskets rapportering.
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| 5. |
- Björkelund, Cecilia, 1948, et al.
(author)
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Long-term effects of a primary health care intervention program for women: lower blood pressure and stable weight
- 2000
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In: Family Medicine. ; 32, s. 246-251
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Journal article (peer-reviewed)abstract
- Department of Primary Health Care, Sahlgrenska Hospital, Göteborg University, Sweden. cecilia.bjorkelund@allmed.gu.se BACKGROUND: In Strömstad, with 10,000 inhabitants, a cardiovascular prevention program was launched during 1985-1987 because of high rates of cardiovascular disease. To study long-term effects in women, an 8-year follow-up was conducted. METHODS: Participants (n = 114) and nonparticipants (n = 269) in the lifestyle intervention program in 1985-1987 (both groups with cardiovascular risk factors) were compared regarding risk factor levels after 8 years. Effects were also compared to another community not exposed to intervention. RESULTS: After 8 years, intervention participants showed significant reduction of mean systolic blood pressure compared to the control group and had higher intake of dietary fibers and more-positive attitudes to and better knowledge of healthy diets. There was no increase of mean body weight or serum triglyceride levels whatsoever in the intervention group. Compared with another female population not exposed to intervention, body weight and systolic blood pressure changed in a significantly more favorable way. CONCLUSIONS: Results from the prevention program could be discerned after 8 years. Advantages in risk factor changes could also be found when comparing with another female population. Given the high level of stroke in women within the community, the blood pressure advantage in the intervention group is particularly encouraging. PMID: 10782370 [PubMed - indexed for MEDLINE]
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| 6. |
- Dahlqvist, Johanna, 1979-, et al.
(author)
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Identification and functional characterization of a novel susceptibility locus for small vessel vasculitis with MPO-ANCA
- 2022
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In: Rheumatology. - Oxford, United Kingdom : Oxford University Press (OUP). - 1462-0324 .- 1462-0332. ; 61:8, s. 3461-3470
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Journal article (peer-reviewed)abstract
- Objective To identify and characterize genetic loci associated with the risk of developing ANCA-associated vasculitides (AAV). Methods Genetic association analyses were performed after Illumina sequencing of 1853 genes and subsequent replication with genotyping of selected single nucleotide polymorphisms in a total cohort of 1110 Scandinavian cases with granulomatosis with polyangiitis or microscopic polyangiitis, and 1589 controls. A novel AAV-associated single nucleotide polymorphism was analysed for allele-specific effects on gene expression using luciferase reporter assay. Results PR3-ANCA(+) AAV was significantly associated with two independent loci in the HLA-DPB1/HLA-DPA1 region [rs1042335, P = 6.3 x 10(-61), odds ratio (OR) 0.10; rs9277341, P = 1.5 x 10(-44), OR 0.22] and with rs28929474 in the SERPINA1 gene (P = 2.7 x 10(-10), OR 2.9). MPO-ANCA(+) AAV was significantly associated with the HLA-DQB1/HLA-DQA2 locus (rs9274619, P = 5.4 x 10(-25), OR 3.7) and with a rare variant in the BACH2 gene (rs78275221, P = 7.9 x 10(-7), OR 3.0), the latter a novel susceptibility locus for MPO-ANCA(+) granulomatosis with polyangiitis/microscopic polyangiitis. The rs78275221-A risk allele reduced luciferase gene expression in endothelial cells, specifically, as compared with the non-risk allele. Conclusion We identified a novel susceptibility locus for MPO-ANCA(+) AAV and propose that the associated variant is of mechanistic importance, exerting a regulatory function on gene expression in specific cell types.
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| 7. |
- Ekman, Diana, et al.
(author)
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Stratified genetic analysis reveals sex differences in MPO-ANCA-associated vasculitis
- 2023
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In: Rheumatology. - : Oxford University Press. - 1462-0324 .- 1462-0332. ; 62:9, s. 3213-3218
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Journal article (peer-reviewed)abstract
- Objective: To identify and genetically characterize subgroups of patients with ANCA-associated vasculitides (AAV) based on sex and ANCA subtype. Methods: A previously established SNP dataset derived from DNA sequencing of 1853 genes and genotyping of 1088 Scandinavian cases with AAV and 1589 controls was stratified for sex and ANCA subtype and analysed for association with five top AAV SNPs. rs9274619, a lead variant at the HLA-DQB1/HLA-DQA2 locus previously associated with AAV positive for myeloperoxidase (MPO)-ANCA, was analysed for association with the cumulative disease involvement of ten different organ systems. Results: rs9274619 showed a significantly stronger association to MPO-ANCA-positive females than males [P = 2.0 × 10-4, OR = 2.3 (95% CI 1.5, 3.5)], whereas proteinase 3 (PR3)-ANCA-associated variants rs1042335, rs9277341 (HLA-DPB1/A1) and rs28929474 (SERPINA1) were equally associated with females and males with PR3-ANCA. In MPO-ANCA-positive cases, carriers of the rs9274619 risk allele were more prone to disease engagement of eyes [P = 0.021, OR = 11 (95% CI 2.2, 205)] but less prone to pulmonary involvement [P = 0.026, OR = 0.52 (95% CI 0.30, 0.92)]. Moreover, AAV with both MPO-ANCA and PR3-ANCA was associated with the PR3-ANCA lead SNP rs1042335 [P = 0.0015, OR = 0.091 (95% CI 0.0022, 0.55)] but not with rs9274619. Conclusions: Females and males with MPO-ANCA-positive AAV differ in genetic predisposition to disease, suggesting at least partially distinct disease mechanisms between the sexes. Double ANCA-positive AAV cases are genetically similar to PR3-ANCA-positive cases, providing clues to the clinical follow-up and treatment of these patients.
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| 8. |
- Rydberg, Tomas, 1962, et al.
(author)
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Estimating the environmental risk of the societal stock of additives in plastics by a chemical footprint approach
- 2015
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In: SETAC Europe 25th Annual Meeting.
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Conference paper (other academic/artistic)abstract
- Environmental risk posed by additives in products in the technosphere in general and in consumer products in particular, is an important issue that has been, so far, investigated to a relatively limited extent. Previous estimates of the national stock and emissions are available on national scale [1,2,3] but the challenge has remained to understand how important or significant these stocks and emissions are from a risk perspective. The research presented here approaches the challenge by assigning risk characterisation scores to the additives and comparing the outcome with corresponding risk characterisation for biocides. We used the previous estimates om stock and emissions of plastic additives. Data for use of biocides were extracted from the Swedish Chemicals Agency The risk characterisation was carried out by applying USETox characterisation factors (CF), The amount of each substance, has been multiplied with its corresponding CF from USETox. These substance specific risk scores were then added to the overall risk score. It is clear that there are many uncertainties in the calculations. For example the emission calculations in the overall society example seem unreasonably high, in the order of 2 % annually of the total stock. In other work applying an advanced emission model to a limited sample of products, the emission rate is in the order of 0.02 % annually. This indicates that the overall society-wide emissions could be in the order of 500 tons rather than 47000 tons. For the risk scores, the uncertainty is even bigger, as the uncertainty of the CFs themselves come into play, as well as the incomplete availability of CFs. The total risk score for the National total use of biocides is 9.3E+09 CTU. This is to be compared with the risk scores as calculated for the additives, which is 1.3E+12 CTU for the total stock of additives and 3E+10 CTU for the emissions, or possible a factor 100 lower if assuming a similar overestimation as for emissions. The results are very sensitive to the identified uncertainties, and also to lack of CFs for possibly important substances, both among the additives and the biocides.
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| 10. |
- Altunay, Maria, 1992, et al.
(author)
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Solar business model adoption by energy incumbents: the importance of strategic fit
- 2021
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In: Environmental Innovation and Societal Transitions. - : Elsevier BV. - 2210-4224. ; 40, s. 501-520
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Journal article (peer-reviewed)abstract
- This paper answers recent calls to give more attention to the business strategies of incumbent actors regarding innovation and socio-technical transitions. We map the solar business model adoption of 30 Swedish electric utility incumbents and examine to what extent it can be explained by the strategic fit with the utilities' established business models, corporate strategies, and external environment. We find that all three dimensions need to be considered in order to explain adoption. Alignment with the established business model is mainly important concerning activities, resources, and partnerships, and utilities also re-configure solar models to increase this alignment (e.g. through outsourcing). However, it is not the main driver for adoption. Instead, incentives and pressures related to corporate strategies and external environment induce or block retailers from adopting solar models. By demonstrating the importance of strategic fit, these findings provide a more nuanced understanding of industry incumbent's strategies in relation to emerging technologies.
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