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Träfflista för sökning "WFRF:(Palm B) "

Search: WFRF:(Palm B)

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  • 2019
  • Journal article (peer-reviewed)
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  • Khatri, B., et al. (author)
  • Genome-wide association study identifies Sjogren's risk loci with functional implications in immune and glandular cells
  • 2022
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
  • Journal article (peer-reviewed)abstract
    • Sjogren's disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjogren's cases of European ancestry: CD247, NAB1, PTTG1-MIR146A, PRDM1-ATG5, TNFAIP3, XKR6, MAPT-CRHR1, RPTOR-CHMP6-BAIAP6, TYK2, SYNGR1. Polygenic risk scores yield predictability (AUROC = 0.71) and relative risk of 12.08. Interrogation of bioinformatics databases refine the associations, define local regulatory networks of GWS SNPs from the 95% credible set, and expand the implicated gene list to >40. Many GWS SNPs are eQTLs for genes within topologically associated domains in immune cells and/or eQTLs in the main target tissue, salivary glands. The genetic architecture underlying Sjogren's syndrome is not fully understood. Here, the authors perform a genome-wide association study to identify 10 new genetic risk regions, implicating genes involved in immune and salivary gland function.
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  • Result 1-10 of 128
Type of publication
journal article (75)
conference paper (31)
editorial proceedings (11)
reports (6)
research review (2)
doctoral thesis (1)
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book chapter (1)
licentiate thesis (1)
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Type of content
peer-reviewed (83)
other academic/artistic (43)
pop. science, debate, etc. (2)
Author/Editor
Palm, B (34)
Vahter, M (16)
Palm, O (12)
Grander, M (11)
Jonsson, R (8)
Omdal, R (8)
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Rasmussen, A (6)
Rischmueller, M. (6)
Witte, T (6)
Khatri, B (6)
Wahren-Herlenius, M (6)
Mariette, X (6)
PALM, L (6)
Teruel, M (6)
Nermell, B (6)
Martin, J. (5)
Ng, WF (5)
Nordmark, G (5)
Farris, AD (5)
Palm, Stig, 1964 (5)
Jensen, JL (5)
Reksten, TR (5)
Warner, B (5)
Palm, D (5)
Li, H. (4)
Ronnblom, L. (4)
Xu, B (4)
Adrianto, I (4)
James, JA (4)
Scofield, RH (4)
Eriksson, P (4)
Aghakhanian, F (4)
Tessneer, KL (4)
Bowman, SJ (4)
Radfar, L (4)
Eloranta, ML (4)
Kippler, M (4)
Palm, Fredrik (4)
Skarstein, K (4)
Palm, M (4)
Palm, H. (4)
Hammenfors, D (4)
Harari, F (4)
Palm, Øyvind (4)
Adler, A (4)
Sivils, KL (4)
Venuturupalli, S (4)
Alevizos, I (4)
Engelke, F (4)
Nocturne, G (4)
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University
Karolinska Institutet (53)
Royal Institute of Technology (28)
Uppsala University (19)
University of Gothenburg (16)
Linköping University (11)
Lund University (11)
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Umeå University (8)
Chalmers University of Technology (7)
Stockholm University (6)
Luleå University of Technology (4)
RISE (3)
Linnaeus University (2)
IVL Swedish Environmental Research Institute (2)
Halmstad University (1)
University of Gävle (1)
Mid Sweden University (1)
Blekinge Institute of Technology (1)
Swedish University of Agricultural Sciences (1)
Red Cross University College (1)
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Language
English (121)
Swedish (7)
Research subject (UKÄ/SCB)
Engineering and Technology (34)
Medical and Health Sciences (31)
Natural sciences (17)
Social Sciences (3)
Agricultural Sciences (1)

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