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| 2. |
- Dahl, O. E., et al.
(författare)
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Assessment of bleeding after concomitant administration of antiplatelet and anticoagulant agents in lower limb arthroplasty
- 2006
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Ingår i: Pathophysiol Haemost Thromb. - : S. Karger AG. - 1424-8832. ; 35:6, s. 428-34
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Tidskriftsartikel (refereegranskat)abstract
- In an analysis of the Melagatran Thrombosis Prophylaxis in Orthopedic Surgery (METHRO) III study, we evaluated whether concomitant administration of aspirin (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) with the direct thrombin inhibitor melagatran/ximelagatran or the low-molecular-weight heparin enoxaparin increased bleeding in patients undergoing major joint surgery. Further objectives were to compare the influence of the timing of initial postoperative administration of melagatran/ximelagatran on bleeding in orthopedic patients receiving ASA/NSAIDs and in comparison with the preoperative administration of enoxaparin. ASA or NSAIDs in conjunction with melagatran/ximelagatran or enoxaparin did not increase bleeding. Bleeding rates were not significantly different, irrespective of the timing of the initial postoperative dose of melagatran/ximelagatran (4-8 vs. 4-12 h) when compared with preoperative (12 h) administration of enoxaparin. Transfusion rates were significantly lower with administration of melagatran/ximelagatran compared with enoxaparin.
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| 3. |
- Dahl, O. E., et al.
(författare)
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Postoperative Melagatran/Ximelagatran for the Prevention of Venous Thromboembolism following Major Elective Orthopaedic Surgery : Effects of Timing of First Dose and Risk Factors for Thromboembolism and Bleeding Complications on Efficacy and Safety
- 2005
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Ingår i: Clin Drug Investig. - 1173-2563. ; 25:1, s. 65-77
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: To examine the influence of timing of postoperative initiation of subcutaneous melagatran followed by oral ximelagatran, and of risk factors for venous thromboembolism (VTE; including deep vein thrombosis [DVT] and pulmonary embolism [PE]) and bleeding complications, on the efficacy and safety of this regimen, compared with preoperative enoxaparin sodium, following total hip replacement (THR) or total knee replacement (TKR) surgery. DESIGN: Statistical analyses of efficacy and safety in subgroups of the METHRO III intention-to-treat population. MAIN OUTCOME MEASURES: Main efficacy outcome measures were major VTE (proximal DVT, PE or VTE-related death) and total VTE (distal or proximal DVT, fatal or non-fatal PE). The main safety outcome measures were blood transfusion, severe bleeding events, blood loss, bleeding-related adverse events and need for reoperation. RESULTS: In the combined THR and TKR population, melagatran initiated 4 - <8 hours postoperatively was non-inferior to enoxaparin sodium with respect to the risks of total VTE (absolute risk reduction [ARR] 0; 95% confidence interval [CI] -4.4, 4.4) and major VTE (ARR -0.63; 95% CI -2.94, 1.67). The rate of major VTE was unaffected by the different risk factors. In the combined THR and TKR population, blood transfusion requirements were lower with melagatran/ximelagatran than enoxaparin sodium (odds ratio 0.83; 95% CI 0.71, 0.96; p = 0.016). CONCLUSIONS: Melagatran/ximelagatran initiated 4 - <8 hours postoperatively provided a comparable level of protection against total and major VTE to preoperative enoxaparin sodium. Major VTE rates and safety were consistent across different patient subgroups. Subcutaneous melagatran followed by fixed-dose oral ximelagatran offers an alternative to the standard European low molecular-weight heparin regimen in a wide range of patients.
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| 5. |
- Falk, Kristina, 1972, et al.
(författare)
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Antifibrinolytic proCPU is present in the peritoneal cavity during surgery.
- 2003
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Ingår i: Scandinavian journal of clinical and laboratory investigation. - 0036-5513. ; 63:4, s. 287-96
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Tidskriftsartikel (refereegranskat)abstract
- The fibrinolytic capacity of the peritoneum plays a pivotal role in peritoneal wound healing. During surgery the balance between fibrin deposition and degradation is tilted towards deposition, leading to the formation of adhesions. In blood, carboxypeptidase U (CPU) stabilizes clots by retarding fibrinolysis. The purpose of this study was to investigate whether the more stable zymogen, proCPU, is also present in the peritoneal cavity and, if so, to examine its origin. Levels of proCPU were measured in plasma and serosal peritoneal fluid collected during surgery. Peritoneal biopsies were stained for proCPU. Two-dimensional gel electrophoresis was performed to study the protein composition of the serosal fluid compared to plasma and Western blotting to identify differences in glycosylation of proCPU, indicating possible different cellular origin. Cultured human mesothelial cells were examined for proCPU production under normal conditions and conditions mimicking surgery. We found comparable and correlating levels of proCPU in serosal fluid and plasma. ProCPU was also found where fibrin covered the injured peritoneal surface. A protein composition very similar in serosal fluid and plasma was shown by two-dimensional gel electrophoresis, and the proCPU pattern did not indicate a different origin. No proCPU production was found in cultured mesothelial cells. This is the first study to report on the presence of proCPU in the peritoneal cavity, which seems to be the result of plasma oozing out during the inflammatory reaction to the surgical trauma. This is likely to be important for the balance between fibrin deposition and degradation and thereby in the formation of postoperative adhesions.
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| 7. |
- Grechnev, G. E., et al.
(författare)
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Anisotropy of magnetic properties of Fe1+y Te
- 2014
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Ingår i: Journal of Physics. - : IOP Publishing. - 0953-8984 .- 1361-648X. ; 26:43, s. 436003-
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Tidskriftsartikel (refereegranskat)abstract
- The magnetic properties of Fe1+y Te single crystals (y similar or equal to 0.1 divided by 0.18) were studied at temperatures 4.2 divided by 300 K. At an ambient pressure, with decreasing temperature a drastic drop in chi(T) was confirmed at T similar or equal to 60 divided by 65 K, which appears to be closely related to the antiferromagnetic (AFM) ordering. It is found that the magnitudes of the anisotropy of magnetic susceptibility Delta chi. in the AFM phase are close in the studied samples, whereas the sign of the anisotropy apparently depends on the small variations of the excess iron y in Fe1+y Te samples. The performed DFT calculations of the electronic structure and magnetic properties for the stoichiometric FeTe compound indicate the presence of frustrated AFM ground states. There are very close energies and magnetic moments for the double stripe configurations, with the AFM axes oriented either on the basal plane or along the [0 0 1] direction. Presumably, both these configurations can be realized in Fe1+y Te single crystals, depending on the variations of the excess iron. This can provide different signs of magnetic anisotropy in the AFM phase, presently observed in the Fe1+y Te samples. For these types of AFM configuration, the calculations for the FeTe values of Delta chi are consistent with our experimental data.
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| 8. |
- Grechnev, GE, et al.
(författare)
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Magnetovolume effect in UGa3
- 1999
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Ingår i: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS. - : ELSEVIER SCIENCE BV. - 0304-8853. ; 192:1, s. 137-147
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The magnetic susceptibility chi of the itinerant antiferromagnetic compound UGa3 has been studied experimentally under pressure up to, kbar in the temperature range 64-300 K. This study reveals a pronounced pressure effect on magnetic properties of UGa3 a
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| 9. |
- Grechnev, GE, et al.
(författare)
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Pressure effect on magnetic properties of UGa3
- 1997
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Ingår i: ACTA PHYSICA POLONICA A. - : POLISH ACAD SCIENCES INST PHYSICS. - 0587-4246. ; 92:2, s. 331-333
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- The magnetic susceptibility, chi, of the itinerant antiferromagnetic compound UGa3 was studied under pressure up to 2 kbar in the temperature range 64-300 K. The measured pressure derivative of the Neel temperature is found to be dT(N)/dP = -1.1 K/kbar. I
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