SwePub - search: WFRF:(Pavlov Georges M.)

Enumeration	Reference	Cover	Find
1.	Knop, Katrin, et al. (author) Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems : investigations using a novel fungicide 2013 In: Soft Matter. - : Royal Society of Chemistry (RSC). - 1744-683X .- 1744-6848. ; 9:3, s. 715-726 Journal article (peer-reviewed)abstract Amphiphilic star-shaped poly(epsilon-caprolactone)-block-poly(oligo(ethylene glycol) methacrylate) [PCLa-b-POEGMA(b)](4) block copolymers with four arms and varying degrees of polymerization for the core (PCL) and the shell (POEGMA) were used to investigate the solution behavior in dilute aqueous solution using a variety of techniques, including fluorescence and UV/Vis spectroscopy, dynamic light scattering, analytical ultracentrifugation, and isothermal titration calorimetry. Particular emphasis has been applied to prove that the systems form unimolecular micelles for different hydrophilic/lipophilic balances of the employed materials. In vitro cytotoxicity and hemocompatibility have further been investigated to probe the suitability of these structures for in vivo applications. A novel fungicide was included into the hydrophobic core in aqueous media to test their potential as drug delivery systems. After loading, the materials have been shown to release the drug and to provoke therewith an inhibition of the growth of different fungal strains.

Knop, Katrin, et al. (author)
Amphiphilic star-shaped block copolymers as unimolecular drug delivery systems : investigations using a novel fungicide
2013
In: Soft Matter. - : Royal Society of Chemistry (RSC). - 1744-683X .- 1744-6848. ; 9:3, s. 715-726
Journal article (peer-reviewed)abstract
- Amphiphilic star-shaped poly(epsilon-caprolactone)-block-poly(oligo(ethylene glycol) methacrylate) [PCLa-b-POEGMA(b)](4) block copolymers with four arms and varying degrees of polymerization for the core (PCL) and the shell (POEGMA) were used to investigate the solution behavior in dilute aqueous solution using a variety of techniques, including fluorescence and UV/Vis spectroscopy, dynamic light scattering, analytical ultracentrifugation, and isothermal titration calorimetry. Particular emphasis has been applied to prove that the systems form unimolecular micelles for different hydrophilic/lipophilic balances of the employed materials. In vitro cytotoxicity and hemocompatibility have further been investigated to probe the suitability of these structures for in vivo applications. A novel fungicide was included into the hydrophobic core in aqueous media to test their potential as drug delivery systems. After loading, the materials have been shown to release the drug and to provoke therewith an inhibition of the growth of different fungal strains.

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