| 1. |
|
|
| 2. |
|
|
| 3. |
- Aguado, M. T., et al.
(author)
-
Two apparently unrelated groups of symbiotic annelids, Nautiliniellidae and Calamyzidae (Phyllodocida, Annelida), are a clade of derived chrysopetalid polychaetes
- 2013
-
In: Cladistics. - : Wiley. - 0748-3007. ; 29:6, s. 610-628
-
Journal article (peer-reviewed)abstract
- Nautiliniellidae Miura and Laubier, 1989 is a small family of marine polychaetes with 20 currently described species in 11 genera, most of which are known to live symbiotically in the mantle cavity of bivalves, mainly from cold seeps and hydrothermal vents, while Calamyzidae (Hartmann-Schroder, 1971) including only one described species, Calamyzas amphictenicola Arwidsson 1932 lives as an ectoparasite on ampharetid polychaetes in Swedish waters. Nautiliniellidae and Calamyzidae have both been considered to belong to Phyllodocida, but the few phylogenetic studies including these taxa have found their positions unstable. The internal relationships within Nautiliniellidae are also poorly understood. Using molecular information from both nuclear and mitochondrial genes and morphological data we assessed the systematic placement of Nautiliniellidae (seven species; collected from Pacific hydrothermal vents and cold seeps and one from Atlantic waters) and Calamyzas amphictenicola. Our results show that C. amphictenicola and Nautiliniellidae formed a well-supported clade that is nested within Chrysopetalidae, a free-living group of polychaetes. The chrysopetalid genus Vigtorniella Kiseleva 1992; a bacterial mat grazer found at methane seeps, anoxic basins and whalefalls, formed a paraphyletic grade with respect to the Nautiliniellidae-Calamyzas clade. The internal relationships within the Nautiliniellidae-Calamyzas clade as well as the relationships with their hosts are also examined. As a result we synonymize Calamyzidae and Nautiliniellidae with Chrysopetalidae, with the last as the oldest available family-group name. Within Chrysopetalidae we refer to the subfamilies Chrysopetalinae Ehlers 1864; Dysponetinae Aguado, Nygren & Rouse, herein; and Calamyzinae Hartmann-Schroder, 1971. Calamyzinae contains C. amphictenicola, all taxa formerly in Nautiliniellidae, and the chrysopetalid genus Vigtorniella. (C) The Willi Hennig Society 2013
|
|
| 4. |
- Aguado, T, et al.
(author)
-
The endocannabinoid system drives neural progenitor proliferation
- 2005
-
In: FASEB Journal. - : Wiley. - 1530-6860 .- 0892-6638. ; 19:9, s. 1704-1704
-
Journal article (peer-reviewed)abstract
- The discovery of multipotent neural progenitor (NP) cells has provided strong support for the existence of neurogenesis in the adult brain. However, the signals controlling NP proliferation remain elusive. Endocannabinoids, the endogenous counterparts of marijuana-derived cannabinoids, act as neuromodulators via presynaptic CB1 receptors and also control neural cell death and survival. Here we show that progenitor cells express a functional endocannabinoid system that actively regulates cell proliferation both in vitro and in vivo. Specifically, NPs produce endocannabinoids and express the CB1 receptor and the endocannabinoid-inactivating enzyme fatty acid amide hydrolase ( FAAH). CB1 receptor activation promotes cell proliferation and neurosphere generation, an action that is abrogated in CB1-deficient NPs. Accordingly, proliferation of hippocampal NPs is increased in FAAH-deficient mice. Our results demonstrate that endocannabinoids constitute a new group of signaling cues that regulate NP proliferation and thus open novel therapeutic avenues for manipulation of NP cell fate in the adult brain.
|
|
| 5. |
- Kasauli, Rashida, 1984, et al.
(author)
-
Safety-Critical Systems and Agile Development: A Mapping Study
- 2018
-
In: Proceedings - 44th Euromicro Conference on Software Engineering and Advanced Applications, SEAA 2018. ; , s. 470-477
-
Conference paper (peer-reviewed)abstract
- In the last decades, agile methods had a huge impact on how software is developed. In many cases, this has led to significant benefits, such as quality and speed of software deliv- eries to customers. However, safety-critical systems have widely been dismissed from benefiting from agile methods. Products that include safety critical aspects are therefore faced with a situation in which the development of safety-critical parts can significantly limit the potential speed-up through agile methods, for the full product, but also in the non-safety critical parts. For such products, the ability to develop safety-critical software in an agile way will generate a competitive advantage. In order to enable future research in this important area, we present in this paper a mapping of the current state of praxis based on a mixed method approach. Starting from a workshop with experts from six large Swedish product development companies we develop a lens for our analysis. We then present a systematic mapping study on safety-critical systems and agile development through this lens in order to map potential benefits, challenges, and solution candidates for guiding future research.
|
|
| 6. |
- Wacker, Andreas, et al.
(author)
-
Quantum Cascade Laser: An Emerging Technology
- 2012
-
In: Nonlinear Laser Dynamics From Quantum Dots to Cryptography. - Weinheim, Germany : Wiley-VCH Verlag GmbH & Co. KGaA. - 3527411003 ; , s. 91-110
-
Book chapter (other academic/artistic)
|
|
| 7. |
- Dutta, Sujan, et al.
(author)
-
The effect of electroactive length and intrinsic conductivity on the actuation behaviour of conducting polymer-based yarn actuators for textile muscles
- 2022
-
In: Sensors and actuators. B, Chemical. - : Elsevier. - 0925-4005 .- 1873-3077. ; 370
-
Journal article (peer-reviewed)abstract
- Recently, electrically driven conducting polymer (CP) coated yarns have shown great promise to develop soft wearable applications because of their electrical and mechanical behaviour. However, designing a suitable yarn actuator for textile-based wearables with high strain is challenging. One reason for the low strain is the voltage drop along the yarn, which results in only a part of the yarn being active. To understand the voltage drop mechanism and overcome this issue intrinsically conductive yarns were used to create a highly conductive path along the full length of the yarn actuator. Ag plated knit-de-knit (Ag-KDK) structured polyamide yarns were used as the intrinsically conductive core material of the CP yarn actuators and compared with CP yarn actuators made of a non-conductive core knit-de-knit (KDK) yarn. The CP yarn actuators were fabricated by coating the core yarns with poly(3,4-ethylene dioxythiophene): poly(styrene sulfonic acid) followed by electrochemical polymerization of polypyrrole. Furthermore, to elucidate the effect of the capillarity of the electrolyte through the yarn actuator, two different approaches to electrochemical actuation were applied. All actuating performance of the materials were investigated and quantified in terms of both isotonic displacement and isometric developed forces. The resultant electroactive yarn exhibits high strain (0.64 %) in NaDBS electrolytes as compared to previous CP yarn actuator. The actuation and the electroactivity of the yarn were retained up to 100 cycles. The new highly conductive yarns will shed light on the development of next-generation textile-based exoskeleton suits, assistive devices, wearables, and haptics garments.
|
|
| 8. |
- Dutta, Suman, et al.
(author)
-
The R-diastereomer of 6 '-O-toluoyl-carba-LNA modification in the core region of siRNA leads to 24-times improved RNA silencing potency against the HIV-1 compared to its S-counterpart
- 2011
-
In: MedChemComm. - : Royal Society of Chemistry (RSC). - 2040-2503 .- 2040-2511. ; 2:11, s. 1110-1119
-
Journal article (peer-reviewed)abstract
- The modified siRNA with pure [6'(S)-O-(p-toluoyl)-7'(S)-methyl]-carba-LNA [6'(S)-O-toluoyl-jcLNA] at position T(13) displayed an IC(50) of 79.8 nM, which has been found to be nearly 24-times less potent as a HIV-1 RNAi silencing agent against TAR RNA than that of the corresponding pure [6'(R)-O-(ptoluoyl)-7'(S)-methyl]jcLNA [6'(R)-O-(p-toluoyl)-jcLNA] counterpart [IC(50) 3.3 nM]. The later [6'(R)-O-(p-toluoyl)-jcLNAl-modified siRNAs have been found to be nearly 2-fold more efficient as a silencing agent than the corresponding 6'-deoxy-jcLNA modified siRNA [IC(50) 8.1 nM], and also nearly 3-fold more effective as a silencing agent than that of LNA-modified siRNA [IC(50) 11.7 nM], thereby showing that the 6'-carbon center in the jcLNA-modified siRNA in the core region is relatively more exposed to the Ago protein in the RISC with a clear chirality preference for the siRNA cleavage reaction. It is noteworthy that the IC(50) of jcLNA-modified siRNAs are very comparable to that of the native siRNA [1.8 nM]. The jcLNA derivatized siRNAs, however, have a clear advantage of being, in general, considerably more stable in human serum. The main structural difference in duplexes of the antisense strand of the 6'(R or S)-O-(p-toluoyl)-jcLNA modified siRNA and target RNA duplex is found to be the spatial orientation of the 6'(R)-O-toluoyl group, which is exposed towards the edge of the duplex backbone, while the 6'(S) makes the minor groove relatively inaccessible for the Ago protein in the RISC. Clearly, any further C6'-modification in jcLNA-modified siRNAs with any hydrophobic group for tighter binding and cleavage or for cross-linking in the core region should preferably be done in the 6'(R)-stereochemistry.
|
|
| 9. |
- Dutta, Subhajit, et al.
(author)
-
Three-in-One C2H2-Selectivity-Guided Adsorptive Separation across an Isoreticular Family of Cationic Square-Lattice MOFs
- 2021
-
In: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773.
-
Journal article (peer-reviewed)abstract
- Energy-efficient selective physisorption driven C2H2 separation from industrial C2-C1 impurities such as C2H4, CO2 and CH4 is of great importance in the purification of downstream commodity chemicals. We address this challenge employing a series of isoreticular cationic metal-organic frameworks, namely iMOF-nC (n=5, 6, 7). All three square lattice topology MOFs registered higher C2H2 uptakes versus the competing C2-C1 gases (C2H4, CO2 and CH4). Dynamic column breakthrough experiments on the best-performing iMOF-6C revealed the first three-in-one C2H2 adsorption selectivity guided separation of C2H2 from 1:1 C2H2/CO2, C2H2/C2H4 and C2H2/CH4 mixtures. Density functional theory calculations critically examined the C2H2 selective interactions in iMOF-6C. Thanks to the abundance of square lattice topology MOFs, this study introduces a crystal engineering blueprint for designing C2H2-selective layered metal-organic physisorbents, previously unreported in cationic frameworks.
|
|
| 10. |
- Ahrens, Jens, 1978, et al.
(author)
-
Evaluation of Non-Spherical Scattering Bodies for Ambisonic Microphone Arrays
- 2022
-
In: Proceedings of the AES International Conference. ; 2022-August, s. 58-66
-
Conference paper (peer-reviewed)abstract
- The XMA was recently presented, which is a higher-order ambisonic microphone array with a non-spherical scattering body. The approach is compatible with the also recently presented equatorial microphone array so that also XMAs can be designed with the microphones distributed solely on a circumferential contour around the scattering body. This greatly reduces the required number of microphones compared to classical spherical microphone arrays that require the microphones to be distributed over the entire surface of the scatterer. The equatorial XMA has so far only been evaluated as a head-mounted array, i.e. with a human head as the baffle. Other form factors of a range of sizes are also of practical relevance, particularly those form factors of 360 cameras as these are capable of capturing a complete panoramic audio-visual experience from a first-person view when combined with an equatorial XMA. We present a set of simulations based on which we identify what spherical harmonic orders can be obtained with what accuracy for a set of convex scattering body geometries that are of relevance in the given context. We demonstrate that the shape of the body is not very critical, and even corners are possible. The main limitation is that small bodies do not allow for extracting higher orders at low frequencies.
|
|
