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1.	Jacobsson, Erik, et al. (author) Peptide toxins from the longest animal on earth 2016 In: Planta Medica. - : Georg Thieme Verlag KG. - 0032-0943 .- 1439-0221. ; 82 Journal article (other academic/artistic)
2.	Andersson, Håkan S., 1967-, et al. (author) Alpha-nemertides, a novel family of marine peptide neurotoxins from ribbon worms 2017 Conference paper (other academic/artistic)
3.	Jacobsson, E, et al. (author) Functional Characterization of the Nemertide α Family of Peptide Toxins 2021 In: Journal of natural products. - : American Chemical Society (ACS). - 1520-6025 .- 0163-3864. ; 84:8, s. 2121-2128 Journal article (peer-reviewed)
4.	Jacobsson, Erik, et al. (author) Peptide ion channel toxins from the bootlace worm, the longest animal on Earth 2018 In: Scientific Reports. - : Nature Publishing Group. - 2045-2322. ; 8 Journal article (peer-reviewed)abstract Polypeptides from animal venoms have found important uses as drugs, pharmacological tools, and within biotechnological and agricultural applications. We here report a novel family of cystine knot peptides from nemertean worms, with potent activity on voltage-gated sodium channels. These toxins, named the alpha-nemertides, were discovered in the epidermal mucus of Lineus longissimus, the 'bootlace worm' known as the longest animal on earth. The most abundant peptide, the 31-residue long alpha-1, was isolated, synthesized, and its 3D NMR structure determined. Transcriptome analysis including 17 species revealed eight alpha-nemertides, mainly distributed in the genus Lineus. alpha-1 caused paralysis and death in green crabs (Carcinus maenas) at 1 mu g/kg (similar to 300 pmol/kg). It showed profound effect on invertebrate voltage-gated sodium channels (e.g. Blattella germanica Na(v)1) at low nanomolar concentrations. Strong selectivity for insect over human sodium channels indicates that a-nemertides can be promising candidates for development of bioinsecticidal agents.
5.	Laborde, Q, et al. (author) The toxicity of Alpha-Nemertide 1 Peptide Alanine-Mutants from the Marine Nemertean Worm Lineus longissimus 2022 In: JOURNAL OF PEPTIDE SCIENCE. - 1075-2617. ; 28 Conference paper (other academic/artistic)

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Type of publication: journal article (3); conference paper (2)

Type of content: other academic/artistic (3); peer-reviewed (2)

Author/Editor: Rosengren, K. Johan (3); Strand, Malin (3); Andersson, Håkan S., ... (3); Jacobsson, Erik (3); Peigneur, S (3); Tytgat, J (3); show more...; Göransson, Ulf, 1970 ... (2); Peigneur, Steve (2); Tytgat, Jan (2); Eriksson, Camilla (2); Jacobsson, E. (2); Laborde, Q (2); Goransson, U (2); Göransson, Ulf (1); Andersson, H. (1); Andrén, Per E. (1); Strand, M (1); Lodén, Henrik (1); Shariatgorji, Mohamm ... (1); Lebbe, Eline (1); Andersson, HS (1); Lebbe, Eline K. M. (1); Lebbe, E. (1); show less...

University: Linnaeus University (3); Uppsala University (2); Karolinska Institutet (2); Swedish University of Agricultural Sciences (2)

Language: English (5)

Research subject (UKÄ/SCB): Natural sciences (3); Medical and Health Sciences (2)

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