| 1. |
- Yang, Wen-Yi, et al.
(author)
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Association of Office and Ambulatory Blood Pressure With Mortality and Cardiovascular Outcomes
- 2019
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In: Journal of the American Medical Association (JAMA). - : AMER MEDICAL ASSOC. - 0098-7484 .- 1538-3598. ; 322:5, s. 409-420
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Journal article (peer-reviewed)abstract
- ImportanceBlood pressure (BP) is a known risk factor for overall mortality and cardiovascular (CV)-specific fatal and nonfatal outcomes. It is uncertain which BP index is most strongly associated with these outcomes. ObjectiveTo evaluate the association of BP indexes with death and a composite CV event. Design, Setting, and ParticipantsLongitudinal population-based cohort study of 11135 adults from Europe, Asia, and South America with baseline observations collected from May 1988 to May 2010 (last follow-ups, August 2006-October 2016). ExposuresBlood pressure measured by an observer or an automated office machine; measured for 24 hours, during the day or the night; and the dipping ratio (nighttime divided by daytime readings). Main Outcomes and MeasuresMultivariable-adjusted hazard ratios (HRs) expressed the risk of death or a CV event associated with BP increments of 20/10 mm Hg. Cardiovascular events included CV mortality combined with nonfatal coronary events, heart failure, and stroke. Improvement in model performance was assessed by the change in the area under the curve (AUC). ResultsAmong 11135 participants (median age, 54.7 years, 49.3% women), 2836 participants died (18.5 per 1000 person-years) and 2049 (13.4 per 1000 person-years) experienced a CV event over a median of 13.8 years of follow-up. Both end points were significantly associated with all single systolic BP indexes (P<.001). For nighttime systolic BP level, the HR for total mortality was 1.23 (95% CI, 1.17-1.28) and for CV events, 1.36 (95% CI, 1.30-1.43). For the 24-hour systolic BP level, the HR for total mortality was 1.22 (95% CI, 1.16-1.28) and for CV events, 1.45 (95% CI, 1.37-1.54). With adjustment for any of the other systolic BP indexes, the associations of nighttime and 24-hour systolic BP with the primary outcomes remained statistically significant (HRs ranging from 1.17 [95% CI, 1.10-1.25] to 1.87 [95% CI, 1.62-2.16]). Base models that included single systolic BP indexes yielded an AUC of 0.83 for mortality and 0.84 for the CV outcomes. Adding 24-hour or nighttime systolic BP to base models that included other BP indexes resulted in incremental improvements in the AUC of 0.0013 to 0.0027 for mortality and 0.0031 to 0.0075 for the composite CV outcome. Adding any systolic BP index to models already including nighttime or 24-hour systolic BP did not significantly improve model performance. These findings were consistent for diastolic BP. Conclusions and RelevanceIn this population-based cohort study, higher 24-hour and nighttime blood pressure measurements were significantly associated with greater risks of death and a composite CV outcome, even after adjusting for other office-based or ambulatory blood pressure measurements. Thus, 24-hour and nighttime blood pressure may be considered optimal measurements for estimating CV risk, although statistically, model improvement compared with other blood pressure indexes was small.
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| 2. |
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| 3. |
- Rex, M., et al.
(author)
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The far-infrared/submillimeter properties of galaxies located behind the Bullet cluster
- 2010
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 518:Article Number: L13
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Journal article (peer-reviewed)abstract
- The Herschel Lensing Survey (HLS) takes advantage of gravitational lensing by massive galaxy clusters to sample a population of high-redshift galaxies which are too faint to be detected above the confusion limit of current far-infrared/submillimeter telescopes. Measurements from 100-500 mu m bracket the peaks of the far-infrared spectral energy distributions of these galaxies, characterizing their infrared luminosities and star formation rates. We introduce initial results from our science demonstration phase observations, directed toward the Bullet cluster (1E0657-56). By combining our observations with LABOCA 870 mu m and AzTEC 1.1 mm data we fully constrain the spectral energy distributions of 19 MIPS 24 mu m-selected galaxies which are located behind the cluster. We find that their colors are best fit using templates based on local galaxies with systematically lower infrared luminosities. This suggests that our sources are not like local ultra-luminous infrared galaxies in which vigorous star formation is contained in a compact highly dust-obscured region. Instead, they appear to be scaled up versions of lower luminosity local galaxies with star formation occurring on larger physical scales.
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| 4. |
- Thai, T. T., et al.
(author)
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Probing the faint-end luminosity function of Lyman-alpha emitters at 3 < z < 7 behind 17 MUSE lensing clusters
- 2023
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In: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 678
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Journal article (peer-reviewed)abstract
- Context. This paper presents a study of the galaxy Lyman-alpha luminosity function (LF) using a large sample of 17 lensing clusters observed by the Multi Unit Spectroscopic Explorer (MUSE) at the ESO Very Large Telescope (VLT). The magnification resulting from strong gravitational lensing by clusters of galaxies and MUSE spectroscopic capabilities allows for blind detections of LAEs without any photometric pre-selection, reaching the faint luminosity regime.Aims. The present work aims to constrain the abundance of Lyman-alpha emitters (LAEs) and quantify their contribution to the total cosmic reionization budget.Methods. We selected 600 lensed LAEs behind these clusters in the redshift range of 2.9 < z < 6.7, covering four orders of magnitude in magnification-corrected Ly-α luminosity (39.0 < log(L)[erg s−1] < 43.0). These data were collected behind lensing clusters, indicating an increased complexity in the computation of the LF to properly account for magnification and dilution effects. We applied a non-parametric Vmax method to compute the LF to carefully determine the survey volume where an individual source could have been detected. The method used in this work follows the recipes originally developed in previous works, with some improvements to better account for the effects of lensing when computing the effective volume.Results. The total co-moving volume at 2.9 < z < 6.7 in the present survey is ∼50 103 Mpc3. Our LF points in the bright end (log(L) [erg s−1] > 42) are consistent with those obtained from blank field observations. In the faint luminosity regime, the density of sources is well described by a steep slope, α ∼ −2 for the global redshift range. Up to log(L) [erg s−1] ∼ 41, the steepening of the faint end slope with redshift, suggested in earlier works, is observed, but the uncertainties are still large. A significant flattening is observed towards the faintest end, for the highest redshift bins, namely, log(L)[erg s−1] < 41.Conclusions. When taken at face value, the steep slope at the faint-end causes the star formation rate density (SFRD) to dramatically increase with redshift, implying that LAEs could play a major role in the process of cosmic reionization. The flattening observed towards the faint end for the highest redshift bins still requires further investigation. This turnover is similar to the one observed for the UV LF at z ≥ 6 in lensing clusters, with the same conclusions regarding the reliability of current results. Improving the statistical significance of the sample in this low-luminosity high-redshift regime is a difficult endeavour that may lead to potentially valuable leads in understanding the process of reionization.
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| 5. |
- Boone, F., et al.
(author)
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An extended Herschel drop-out source in the center of AS1063: A normal dusty galaxy at z = 6.1 or SZ substructures?
- 2013
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 559, s. L1-
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Journal article (peer-reviewed)abstract
- In the course of our 870 μm APEX/LABOCA follow-up of the Herschel Lensing Survey we have detected a source in AS1063 (RXC J2248.7-4431) that has no counterparts in any of the Herschel PACS/SPIRE bands, it is a Herschel "drop-out" with S870=S500 ≥ 0:5. The 870 μm emission is extended and centered on the brightest cluster galaxy, suggesting either a multiply imaged background source or substructure in the Sunyaev-Zel'dovich increment due to inhomogeneities in the hot cluster gas of this merging cluster. We discuss both interpretations with emphasis on the putative lensed source. Based on the observed properties and on our lens model we find that this source may be the first submillimeter galaxy (SMG) with a moderate far-infrared (FIR) luminosity (LFIR. © ESO 2013.
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| 6. |
- de La Vieuville, G., et al.
(author)
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Faint end of the z similar to 3-7 luminosity function of Lyman-alpha emitters behind lensing clusters observed with MUSE
- 2019
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 628
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Journal article (peer-reviewed)abstract
- Contact. This paper presents the results obtained with the Multi-Unit Spectroscopic Explorer (MUSE) at the ESOVery Large Telescope on the faint end of the Lyman-alpha luminosity function (LF) based on deep observations of four lensing clusters. The goal of our project is to set strong constraints on the relative contribution of the Lyman-alpha emitter (LAE) population to cosmic reionization.Aims. The precise aim of the present study is to further constrain the abundance of LAEs by taking advantage of the magnification provided by lensing clusters to build a blindly selected sample of galaxies which is less biased than current blank field samples in redshift and luminosity. By construction, this sample of LAEs is complementary to those built from deep blank fields, whether observed by MUSE or by other facilities, and makes it possible to determine the shape of the LF at fainter levels, as well as its evolution with redshift.Methods. We selected a sample of 156 LAEs with redshifts between 2.9 <= z <= 6.7 and magnification-corrected luminosities in the range 39 less than or similar to log L-Ly alpha [erg s(-1)] less than or similar to 43. To properly take into account the individual differences in detection conditions between the LAEs when computing the LF, including lensing configurations, and spatial and spectral morphologies, the non-parametric 1/V-max method was adopted. The price to pay to benefit from magnification is a reduction of the effective volume of the survey, together with a more complex analysis procedure to properly determine the effective volume V-max for each galaxy. In this paper we present a complete procedure for the determination of the LF based on IFU detections in lensing clusters. This procedure, including some new methods for masking, effective volume integration and (individual) completeness determinations, has been fully automated when possible, and it can be easily generalized to the analysis of IFU observations in blank fields.Results. As a result of this analysis, the Lyman-alpha LF has been obtained in four different redshift bins: 2.9 < z < 6; 7, 2.9 < z < 4.0, 4 : 0 < z < 5.0; and 5 : 0 < z < 6.7 with constraints down to log L-Ly alpha = 40.5. From our data only, no significant evolution of LF mean slope can be found. When performing a Schechter analysis also including data from the literature to complete the present sample towards the brightest luminosities, a steep faint end slope was measured varying from alpha = -1.69(-0.08)(+0.08) to alpha = -1.87(-0 .12)(+0.12) between the lowest and the highest redshift bins.Conclusions. The contribution of the LAE population to the star formation rate density at z similar to 6 is less than or similar to 50% depending on the luminosity limit considered, which is of the same order as the Lyman-break galaxy (LBG) contribution. The evolution of the LAE contribution with redshift depends on the assumed escape fraction of Lyman-alpha photons, and appears to slightly increase with increasing redshift when this fraction is conservatively set to one. Depending on the intersection between the LAE/LBG populations, the contribution of the observed galaxies to the ionizing flux may suffice to keep the universe ionized at z similar to 6.
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| 7. |
- Drake, A. B., et al.
(author)
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The MUSE Hubble Ultra Deep Field Survey VI. The faint-end of the Lyα luminosity function at 2.91
- 2017
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 608
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Journal article (peer-reviewed)abstract
- We present the deepest study to date of the Ly alpha luminosity function in a blank field using blind integral field spectroscopy from MUSE. We constructed a sample of 604 Ly alpha emitters (LAEs) across the redshift range 2.91 < z < 6.64 using automatic detection software in the Hubble Ultra Deep Lield. The deep data cubes allowed us to calculate accurate total Ly alpha fluxes capturing low surface-brightness extended Ly alpha emission now known to be a generic property of high-redshift star-forming galaxies. We simulated realistic extended LAEs to fully characterise the selection function of our samples, and performed flux-recovery experiments to test and correct for bias in our determination of total Ly alpha fluxes. We find that an accurate completeness correction accounting for extended emission reveals a very steep faint-end slope of the luminosity function, alpha, down to luminosities of log(10) L erg s(-1) < 41.5, applying both the 1/V-max and maximum likelihood estimators. Splitting the sample into three broad redshift bins, we see the faint-end slope increasing from -2.03(-0.07)(+1.42) at z approximate to 3.44 to -2.86(-infinity)(+0.76) Z approximate to 76 at z approximate to 5.48, however no strong evolution is seen between the 68% confidence regions in L*-alpha parameter space. Using the Ly alpha line flux as a proxy for star formation activity, and integrating the observed luminosity functions, we find that LAEs' contribution to the cosmic star formation rate density rises with redshift until it is comparable to that from continuum-selected samples by z approximate to 6. This implies that LAEs may contribute more to the star-formation activity of the early Universe than previously thought, as any additional intergalactic medium (IGM) correction would act to further boost the Ly alpha luminosities. Linally, assuming fiducial values for the escape of Ly alpha and LyC radiation, and the dumpiness of the IGM, we integrated the maximum likelihood luminosity function at 5.00 < z < 6.64 and find we require only a small extrapolation beyond the data (<1 dex in luminosity) for LAEs alone to maintain an ionised IGM at z approximate to 6.
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| 8. |
- Fernández-Pello, Sergio, et al.
(author)
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A Systematic Review and Meta-analysis Comparing the Effectiveness and Adverse Effects of Different Systemic Treatments for Non-clear Cell Renal Cell Carcinoma
- 2017
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In: European Urology. - : Elsevier BV. - 0302-2838 .- 1873-7560. ; 71:3, s. 426-436
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Research review (peer-reviewed)abstract
- Context While vascular endothelial growth factor-targeted therapy and mammalian target of rapamycin inhibition are effective strategies in treating clear cell renal cell carcinoma (ccRCC), the most effective therapeutic approach for patients with non-clear cell RCC (non-ccRCC) is unknown. Objective To systematically review relevant literature comparing the oncological outcomes and adverse events of different systemic therapies for patients with metastatic non-ccRCC. Evidence acquisition Relevant databases including MEDLINE, Embase, and the Cochrane Library were searched up to March 24, 2016. Only comparative studies were included. Risk of bias and confounding assessments were performed. A meta-analysis was planned for and only performed if methodologically appropriate; otherwise, a narrative synthesis was undertaken. Evidence synthesis The literature search identified 812 potential titles and abstracts. Five randomized controlled trials, recruiting a total of 365 patients, were included. Three studies compared sunitinib against everolimus, one of which reported the results for non-ccRCC as a subgroup rather than as an entire randomized cohort. Individually, the studies showed a trend towards favoring sunitinib in terms of overall survival and progression-free survival (PFS; Everolimus versus Sunitinib in Patients with Metastatic Non-clear Cell Renal Cell Carcinoma hazard ratio [HR]: 1.41, 80% confidence interval [CI] 1.03–1.92 and 1.41, 95% CI: 0.88–2.27, Evaluation in Metastatic Non-clear Cell Renal Cell Carcinoma HR: 1.16, 95% CI: 0.67–2.01, Efficacy and Safety Comparison of RAD001 Versus Sunitinib in the First-line and Second-line Treatment of Patients with Metastatic Renal Cell Carcinoma HR: 1.5, 95% CI: 0.9–2.8), but this trend did not reach statistical significance in any study. Meta-analysis was performed on two studies which solely recruited patients with non-ccRCC reporting on PFS, the results of which were inconclusive (HR: 1.30, 95% CI: 0.91–1.86). Sunitinib was associated with more Grade 3–4 adverse events than everolimus, although this was not statistically significant. Conclusions This systematic review and meta-analysis represent a robust summary of the evidence base for systemic treatment of metastatic non-ccRCC. The results show a trend towards favoring vascular endothelial growth factor-targeted therapy for PFS and overall survival compared with mammalian target of rapamycin inhibitors, although statistical significance was not reached. The relative benefits and harms of these treatments remain uncertain. Further research, either in the form of an individual patient data meta-analysis involving all relevant trials, or a randomized controlled trial with sufficient power to detect potential differences between treatments, is needed. Patient summary We examined the literature to determine the most effective treatments for advanced kidney cancer patients whose tumors are not of the clear cell subtype. The results suggest that a drug called sunitinib might be more effective than everolimus, but the statistics supporting this statement are not yet entirely reliable. Further research is required to clarify this unmet medical need.
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| 9. |
- Goovaerts, I., et al.
(author)
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Evolution of the Lyman-α-emitting fraction and UV properties of lensed star-forming galaxies in the range 2.9 < z < 6.7
- 2023
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In: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 678
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Journal article (peer-reviewed)abstract
- Context. Faint galaxies are theorised to have played a major role, perhaps the dominant role, in reionising the Universe. Their properties, as well as the Lyman-α emitter (LAE) fraction, XLAE, could provide useful insights into this epoch.Aims. We used four clusters of galaxies from the Lensed Lyman-alpha MUSE Arcs Sample (LLAMAS) that also have deep HST photometry to select a population of intrinsically faint Lyman break galaxies (LBGs) and LAEs. We study the interrelation between these two populations, their properties, and the fraction of LBGs that display Lyman-α emission.Methods. The use of lensing clusters allows us to access an intrinsically faint population of galaxies, the largest such sample collected for this purpose: 263 LAEs and 972 LBGs with redshifts between 2.9 and 6.7, Lyman-α luminosities in the range 39.5 ≲ log(LLyα)(erg s−1)≲42, and absolute UV magnitudes in the range −22 ≲ M1500 ≲ −12. In addition to matching LAEs and LBGs, we define an LAE+continuum sample for the LAEs that match with a continuum object that is not selected as an LBG. Additionally, with the use of MUSE integral field spectroscopy, we detect a population of LAEs completely undetected in the continuum.Results. We find a redshift evolution of XLAE in line with literature results, with diminished values above z = 6. In line with past studies, we take this as signifying an increasingly neutral intervening intergalactic medium. When inspecting this redshift evolution with different limits on EWLyα and M1500, we find that the XLAE for the UV-brighter half of our sample is higher than the XLAE for the UV-fainter half, a difference that increases at higher redshifts. This is a surprising result and can be interpreted as the presence of a population of low Lyman-α equivalent width (EWLyα), UV-bright galaxies situated in reionised bubbles and overdensities. This result is especially interesting in the context of similar, UV-bright, low EWLyα objects recently detected during and around the epoch of reionisation. For intrinsically fainter objects, we confirm the previously observed trend of LAEs among LBGs as galaxies with high star formation rates and low dust content, as well as the trend of the strongest LAEs having, in general, fainter M1500 and steeper UV slopes.
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| 10. |
- Hashimoto, Takuya, et al.
(author)
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The onset of star formation 250 million years after the Big Bang
- 2018
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In: Nature. - : NATURE PUBLISHING GROUP. - 0028-0836 .- 1476-4687. ; 557:7705, s. 392-395
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Journal article (peer-reviewed)abstract
- A fundamental quest of modern astronomy is to locate the earliest galaxies and study how they influenced the intergalactic medium a few hundred million years after the Big Bang(1-3). The abundance of star-forming galaxies is known to decline(4,5) from redshifts of about 6 to 10, but a key question is the extent of star formation at even earlier times, corresponding to the period when the first galaxies might have emerged. Here we report spectroscopic observations of MACS1149-JD1(6), a gravitationally lensed galaxy observed when the Universe was less than four per cent of its present age. We detect an emission line of doubly ionized oxygen at a redshift of 9.1096 +/- 0.0006, with an uncertainty of one standard deviation. This precisely determined redshift indicates that the red rest-frame optical colour arises from a dominant stellar component that formed about 250 million years after the Big Bang, corresponding to a redshift of about 15. Our results indicate that it may be possible to detect such early episodes of star formation in similar galaxies with future telescopes.
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