| 1. |
- Kehoe, Laura, et al.
(author)
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Make EU trade with Brazil sustainable
- 2019
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Journal article (other academic/artistic)
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| 2. |
- Andersson, Lars M, et al.
(author)
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En man med många talanger
- 2002
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In: På historiens slagfält. En festskrift tillägnad Sverker Oredsson. - Uppsala : Sisyfos. - 9163131048 ; , s. 19-23
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Book chapter (other academic/artistic)
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| 3. |
- Boen, Rune, et al.
(author)
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Beyond the global brain differences : intraindividual variability differences in 1q21.1 distal and 15q11.2 bp1-bp2 deletion carriers
- 2024
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In: Biological Psychiatry. - 0006-3223 .- 1873-2402. ; 95:2, s. 147-160
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Journal article (peer-reviewed)abstract
- Background: Carriers of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants exhibit regional and global brain differences compared with noncarriers. However, interpreting regional differences is challenging if a global difference drives the regional brain differences. Intraindividual variability measures can be used to test for regional differences beyond global differences in brain structure.Methods: Magnetic resonance imaging data were used to obtain regional brain values for 1q21.1 distal deletion (n = 30) and duplication (n = 27) and 15q11.2 BP1-BP2 deletion (n = 170) and duplication (n = 243) carriers and matched noncarriers (n = 2350). Regional intra-deviation scores, i.e., the standardized difference between an individual's regional difference and global difference, were used to test for regional differences that diverge from the global difference.Results: For the 1q21.1 distal deletion carriers, cortical surface area for regions in the medial visual cortex, posterior cingulate, and temporal pole differed less and regions in the prefrontal and superior temporal cortex differed more than the global difference in cortical surface area. For the 15q11.2 BP1-BP2 deletion carriers, cortical thickness in regions in the medial visual cortex, auditory cortex, and temporal pole differed less and the prefrontal and somatosensory cortex differed more than the global difference in cortical thickness.Conclusions: We find evidence for regional effects beyond differences in global brain measures in 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants. The results provide new insight into brain profiling of the 1q21.1 distal and 15q11.2 BP1-BP2 copy number variants, with the potential to increase understanding of the mechanisms involved in altered neurodevelopment.
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| 4. |
- de Bont, Jeroen, et al.
(author)
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Mixtures of long-term exposure to ambient air pollution, built environment and temperature and stroke incidence across Europe
- 2023
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In: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 179
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Journal article (peer-reviewed)abstract
- Introduction: The complex interplay of multiple environmental factors and cardiovascular has scarcely been studied. Within the EXPANSE project, we evaluated the association between long-term exposure to multiple environmental indices and stroke incidence across Europe.Methods: Participants from three traditional adult cohorts (Germany, Netherlands and Sweden) and four administrative cohorts (Catalonia [region Spain], Rome [city-wide], Greece and Sweden [nationwide]) were followed until incident stroke, death, migration, loss of follow-up or study end. We estimated exposures at residential addresses from different exposure domains: air pollution (nitrogen dioxide (NO2), particulate matter < 2.5 μm (PM2.5), black carbon (BC), ozone), built environment (green/blue spaces, impervious surfaces) and meteorology (seasonal mean and standard deviation of temperatures). Associations between environmental exposures and stroke were estimated in single and multiple-exposure Cox proportional hazard models, and Principal Component (PC) Analyses derived prototypes for specific exposures domains. We carried out random effects meta-analyses by cohort type.Results: In over 15 million participants, increased levels of NO2 and BC were associated with increased higher stroke incidence in both cohort types. Increased Normalized Difference Vegetation Index (NDVI) was associated with a lower stroke incidence in both cohort types, whereas an increase in impervious surface was associated with an increase in stroke incidence. The first PC of the air pollution domain (PM2.5, NO2 and BC) was associated with an increase in stroke incidence. For the built environment, higher levels of NDVI and lower levels of impervious surfaces were associated with a protective effect [%change in HR per 1 unit = −2.0 (95 %CI, −5.9;2.0) and −1.1(95 %CI, −2.0; −0.3) for traditional adult and administrative cohorts, respectively]. No clear patterns were observed for distance to blue spaces or temperature parameters.Conclusions: We observed increased HRs for stroke with exposure to PM2.5, NO2 and BC, lower levels of greenness and higher impervious surface in single and combined exposure models.
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| 5. |
- deSouza, Nandita M., et al.
(author)
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Validated imaging biomarkers as decision-making tools in clinical trials and routine practice: current status and recommendations from the EIBALL* subcommittee of the European Society of Radiology (ESR)
- 2019
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In: Insights into Imaging. - : SPRINGEROPEN. - 1869-4101. ; 10:1
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Journal article (peer-reviewed)abstract
- Observer-driven pattern recognition is the standard for interpretation of medical images. To achieve global parity in interpretation, semi-quantitative scoring systems have been developed based on observer assessments; these are widely used in scoring coronary artery disease, the arthritides and neurological conditions and for indicating the likelihood of malignancy. However, in an era of machine learning and artificial intelligence, it is increasingly desirable that we extract quantitative biomarkers from medical images that inform on disease detection, characterisation, monitoring and assessment of response to treatment. Quantitation has the potential to provide objective decision-support tools in the management pathway of patients. Despite this, the quantitative potential of imaging remains under-exploited because of variability of the measurement, lack of harmonised systems for data acquisition and analysis, and crucially, a paucity of evidence on how such quantitation potentially affects clinical decision-making and patient outcome. This article reviews the current evidence for the use of semi-quantitative and quantitative biomarkers in clinical settings at various stages of the disease pathway including diagnosis, staging and prognosis, as well as predicting and detecting treatment response. It critically appraises current practice and sets out recommendations for using imaging objectively to drive patient management decisions.
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| 6. |
- Dytckov, Sergei, 1986-, et al.
(author)
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An Individual-Based Simulation Approach to Demand Responsive Transport
- 2021
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In: Intelligent Transport Systems, From Research and Development to the Market Uptake. - Cham : Springer. - 9783030714543 - 9783030714536 ; , s. 72-89
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Conference paper (peer-reviewed)abstract
- This article demonstrates an approach to the simulation of Demand Responsive Transport (DRT) – a flexible transport mode that typically operates as a combination of taxi and bus modes. Travellers request individual trips and DRT is capable of adjusting its routes or schedule to the needs of travellers. It has been seen as a part of the public transport network, which has the potential to reduce operational costs of public transport services, to provide better service quality for population groups with limited mobility and to improve transport fairness. However, a DRT service needs to be thoroughly planned to target the intended user groups, attract a sufficient demand level and maintain reasonable operational costs. As the demand for DRT is dynamic and heterogeneous, it is difficult to simulate it with a macro approach. To address this problem, we develop and evaluate an individual-based simulation comprising models of traveller behaviour for both supply and demand sides. Travellers choose a trip alternative with a mode choice model and DRT vehicle routing utilises a model of travellers’ mode choice behaviour to optimise routes. This allows capturing supply-side operational costs and demand-side service quality for every individual, what allows for designing a personalised service that can prioritise needy groups of travellers improving transport fairness. By simulating different setups of DRT services, the simulator can be used as a decision support tool.
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| 7. |
- Dytckov, Sergei, 1986-, et al.
(author)
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Modelling Commuting Activities for the Simulation of Demand Responsive Transport in Rural Areas
- 2020
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In: Proceedings of the 6th International Conference on Vehicle Technology and Intelligent Transport Systems. - : SciTePress. - 9789897584190 ; , s. 89-97
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Conference paper (peer-reviewed)abstract
- For the provision of efficient and high-quality public transport services in rural areas with a low population density, the introduction of Demand Responsive Transport (DRT) services is reasonable. The optimal design of such services depends on various socio-demographical and environmental factors, which is why the use of simulation is feasible to support planning and decision-making processes. A key challenge for sound simulation results is the generation of realistic demand, i.e., requests for DRT journeys. In this paper, a method for modelling and simulating commuting activities is presented, which is based on statistical real-world data. It is applied to Sjöbo and Tomelilla, two rural municipalities in southern Sweden.
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| 8. |
- Dytckov, Sergei, 1986-, et al.
(author)
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Potential Benefits of Demand Responsive Transport in Rural Areas : A Simulation Study in Lolland, Denmark
- 2022
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In: Sustainability. - : MDPI. - 2071-1050. ; 14:6
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Journal article (peer-reviewed)abstract
- In rural areas with low demand, demand responsive transport (DRT) can provide an alternative to the regular public transport bus lines, which are expensive to operate in such conditions. With simulation, we explore the potential effects of introducing a DRT service that replaces existing bus lines in Lolland municipality in Denmark, assuming that the existing demand remains unchanged. We set up the DRT service in such a way that its service quality (in terms of waiting time and in-vehicle time) is comparable to the replaced buses. The results show that a DRT service can be more cost efficient than regular buses and can produce significantly less CO2 emissions when the demand level is low. Additionally, we analyse the demand density at which regular buses become more cost efficient and explore how the target service quality of a DRT service can affect operational characteristics. Overall, we argue that DRT could be a more sustainable mode of public transport in low demand areas.
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| 9. |
- Fiedler, Johannes, et al.
(author)
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Dispersion forces in inhomogeneous planarly layered media : A one-dimensional model for effective polarizabilities
- 2019
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In: Physical Review A. - 2469-9926. ; 99:6
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Journal article (peer-reviewed)abstract
- Dispersion forces such as van der Waals forces between two microscopic particles, the Casimir-Polder forces between a particle and a macroscopic object, or the Casimir force between two dielectric objects are well studied in vacuum. However, in realistic situations the interacting objects are often embedded in an environmental medium. Such a solvent influences the induced dipole interaction. With the framework of macroscopic quantum electrodynamics, these interactions are mediated via an exchange of virtual photons. Via this method the impact of a homogeneous solvent medium can be expressed as local-field corrections leading to excess polarizabilities which have previously been derived for hard boundary conditions. In order to develop a more realistic description, we investigate a one-dimensional analog system illustrating the influence of a continuous dielectric profile.
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| 10. |
- Kaarre, Janina, 1996, et al.
(author)
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Anatomic Flat Double-Bundle Medial Collateral Ligament Reconstruction.
- 2023
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In: Arthroscopy techniques. - 2212-6287. ; 12:8
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Journal article (peer-reviewed)abstract
- Several surgical techniques have been described to restore the anatomy of the medial collateral ligament, involving suture repair and reconstruction, with the latter having been associated with superior postoperative outcomes. Recently, a growing interest in anatomic isometric medial collateral ligament reconstruction (MCLR) has been developed, involving careful evaluation and finding the most appropriate location for the femoral placement of the allograft. Therefore, the purpose of this article is to describe anatomic MCLR aiming to restore medial knee stability by focusing on isometric positions within the native anatomy of the MCL.
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