↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Pijuan Sala B) "

Search: WFRF:(Pijuan Sala B)

Result 1-2 of 2

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Ton, M. L. N., et al. (author) An atlas of rabbit development as a model for single-cell comparative genomics 2023 In: Nature Cell Biology. - 1465-7392. ; 25 Journal article (peer-reviewed)abstract Ton, Keitley et al. provide a morphological and molecular atlas of rabbit development. Comparative studies reveal that combining rabbit and mouse atlases can serve as a model for dissecting early primate development. Traditionally, the mouse has been the favoured vertebrate model for biomedical research, due to its experimental and genetic tractability. However, non-rodent embryological studies highlight that many aspects of early mouse development, such as its egg-cylinder gastrulation and method of implantation, diverge from other mammals, thus complicating inferences about human development. Like the human embryo, rabbits develop as a flat-bilaminar disc. Here we constructed a morphological and molecular atlas of rabbit development. We report transcriptional and chromatin accessibility profiles for over 180,000 single cells and high-resolution histology sections from embryos spanning gastrulation, implantation, amniogenesis and early organogenesis. Using a neighbourhood comparison pipeline, we compare the transcriptional landscape of rabbit and mouse at the scale of the entire organism. We characterize the gene regulatory programmes underlying trophoblast differentiation and identify signalling interactions involving the yolk sac mesothelium during haematopoiesis. We demonstrate how the combination of both rabbit and mouse atlases can be leveraged to extract new biological insights from sparse macaque and human data. The datasets and computational pipelines reported here set a framework for a broader cross-species approach to decipher early mammalian development, and are readily adaptable to deploy single-cell comparative genomics more broadly across biomedical research.
2.	Dahlin, JS, et al. (author) A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice 2018 In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 131:21, s. E1-E11 Journal article (peer-reviewed)abstract Single-cell transcriptional landscape of 44 802 hematopoietic stem/progenitor cells defines entry points to 8 different blood lineages. Comparison with 13 815 c-Kit mutant cells identifies pleiotropic changes in cell type abundance and underlying molecular profiles.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-2 of 2

Refine your search

Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Gottgens, B. (2); Pijuan-Sala, B (2); Shepherd, M (1); Imaz-Rosshandler, I. (1); Nichols, J. (1); Marioni, J. C. (1); show more...; Guibentif, Carolina (1); Dahlin, JS (1); Hamey, FK (1); Lau, WWY (1); Nestorowa, S (1); Weinreb, C (1); Wolock, S (1); Hannah, R (1); Diamanti, E (1); Kent, DG (1); Wilson, NK (1); Ton, M. L. N. (1); Keitley, D. (1); Theeuwes, B. (1); Ahnfelt-Ronne, J. (1); Andreassen, T. K. (1); Calero-Nieto, F. J. (1); Benito-Gutierrez, E. (1); show less...

University: University of Gothenburg (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view