| 1. |
- Ahlqvist, Emma, et al.
(författare)
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A link between GIP and osteopontin in adipose tissue and insulin resistance.
- 2013
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Ingår i: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 62:6, s. 2088-2094
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Tidskriftsartikel (refereegranskat)abstract
- Low grade inflammation in obesity is associated with accumulation of the macrophagederived cytokine osteopontin in adipose tissue and induction of local as well as systemic insulin resistance. Since GIP (glucose-dependent insulinotropic polypeptide) is a strong stimulator of adipogenesis and may play a role in the development of obesity, we explored whether GIP directly would stimulate osteopontin (OPN) expression in adipose tissue and thereby induce insulin resistance. GIP stimulated OPN protein expression in a dose-dependent fashion in rat primary adipocytes. The level of OPN mRNA was higher in adipose tissue of obese individuals (0.13±}0.04 vs 0.04±}0.01, P<0.05) and correlated inversely with measures of insulin sensitivity (r=-0.24, P=0.001). A common variant of the GIP receptor (GIPR) (rs10423928) gene was associated with lower amount of the exon 9 containing isoform required for transmembrane activity. Carriers of the A-allele with a reduced receptor function showed lower adipose tissue OPN mRNA levels and better insulin sensitivity. Together, these data suggest a role for GIP not only as an incretin hormone, but also as a trigger of inflammation and insulin resistance in adipose tissue. Carriers of GIPR rs10423928 A-allele showed protective properties via reduced GIP effects. Identification of this unprecedented link between GIP and OPN in adipose tissue might open new avenues for therapeutic interventions.
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| 2. |
- Aissaoui, Nesrine, 1983, et al.
(författare)
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FRET enhancement close to gold nanoparticles positioned in DNA origami constructs
- 2017
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Ingår i: Nanoscale. - Cambridge, United Kingdom : Royal Society of Chemistry (RSC). - 2040-3372 .- 2040-3364. ; 9:2, s. 673-683
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Tidskriftsartikel (refereegranskat)abstract
- Here we investigate the energy transfer rates of a Förster resonance energy transfer (FRET) pair positioned in close proximity to a 5 nm gold nanoparticle (AuNP) on a DNA origami construct. We study the distance dependence of the FRET rate by varying the location of the donor molecule, D, relative to the AuNP while maintaining a fixed location of the acceptor molecule, A. The presence of the AuNP induces an alteration in the spontaneous emission of the donor (including radiative and non-radiative rates) which is strongly dependent on the distance between the donor and AuNP surface. Simultaneously, the energy transfer rates are enhanced at shorter D-A (and D-AuNP) distances. Overall, in addition to the direct influence of the acceptor and AuNP on the donor decay there is also a significant increase in decay rate not explained by the sum of the two interactions. This leads to enhanced energy transfer between donor and acceptor in the presence of a 5 nm AuNP. We also demonstrate that the transfer rate in the three "particle" geometry (D + A + AuNP) depends approximately linearly on the transfer rate in the donor-AuNP system, suggesting the possibility to control FRET process with electric field induced by 5 nm AuNPs close to the donor fluorophore. It is concluded that DNA origami is a very versatile platform for studying interactions between molecules and plasmonic nanoparticles in general and FRET enhancement in particular.
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| 3. |
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| 4. |
- Bharmoria, Pankaj, et al.
(författare)
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Far-red triplet sensitized Z-to-E photoswitching of azobenzene in bioplastics
- 2022
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Ingår i: Chemical Science. - : Royal Society of Chemistry (RSC). - 2041-6520 .- 2041-6539. ; 13, s. 11904-11911
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Tidskriftsartikel (refereegranskat)abstract
- We report the first example of direct far-red triplet sensitized molecular photoswitching in a condensed phase wherein a liquid azobenzene derivative (Azo1) co-assembled within a liquid surfactant-protein film undergoes triplet sensitized Z-to-E photoswitching upon far-red/red light excitation in air. The role of triplet sensitization in photoswitching has been confirmed by quenching of sensitizer phosphorescence by Z-Azo1 and temperature-dependent photoswitching experiments. Herein, we demonstrate new biosustainable fabrication designs to address key challenges in solid-state photoswitching, effectively mitigating chromophore aggregation and requirement of high energy excitations by dispersing the photoswitch in the trapped liquid inside the solid framework and by shifting the action spectrum from blue-green light (450-560 nm) to the far-red/red light (740/640 nm) region.
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| 5. |
- Bharmoria, Pankaj, 1985, et al.
(författare)
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Recyclable optical bioplastics platform for solid state red light harvesting via triplet-triplet annihilation photon upconversion
- 2022
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Ingår i: Journal of Materials Chemistry A. - : Royal Society of Chemistry (RSC). - 2050-7496 .- 2050-7488. ; 10:40, s. 21279-21290
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Tidskriftsartikel (refereegranskat)abstract
- Sustainable photonics applications of solid-state triplet-triplet annihilation photon upconversion (TTA-UC) are limited by a small UC spectral window, low UC efficiency in air, and non-recyclability of polymeric materials used. In a step to overcome these issues, we have developed new recyclable TTA-UC bioplastics by encapsulating TTA-UC chromophores liquid inside the semicrystalline gelatin films showing broad-spectrum upconversion (red/far-red to blue) with high UC efficiency in air. For this, we synthesized a new anionic annihilator, sodium-TIPS-anthracene-2-sulfonate (TIPS-AnS), that combined with red/far-red sensitizers (PdTPBP/Os(m-peptpy)(2)(TFSI)(2)), a liquid surfactant Triton X-100 reduced (TXr) and protein gelatin (G) formed red/far-red to blue TTA-UC bioplastic films just by air drying of their aqueous solutions. The G-TXr-TIPS-AnS-PdTPBP film showed record red to blue (633 to 478 nm) TTA-UC quantum yield of 8.5% in air. The high UC quantum yield has been obtained due to the fluidity of dispersed TXr containing chromophores and oxygen blockage by gelatin fibers that allowed efficient diffusion of triplet excited chromophores. Further, the G-TXr-TIPS-AnS-Os(m-peptpy)(2)(TFSI)(2) bioplastic film displayed far-red to blue (700-730 nm to 478 nm) TTA-UC, demonstrating broad-spectrum photon harvesting. Finally, we demonstrated the recycling of G-TXr-TIPS-AnS-PdTPBP bioplastics by developing a downstream approach that gives new directions for designing future recyclable photonics bioplastic materials.
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| 6. |
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| 7. |
- Börjesson, Karl, 1982, et al.
(författare)
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Conjugated anthracene dendrimers with monomer-like fluorescence
- 2014
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Ingår i: RSC Advances. - : Royal Society of Chemistry (RSC). - 2046-2069. ; 4:38, s. 19846-19850
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Tidskriftsartikel (refereegranskat)abstract
- Two generations of highly emissive conjugated anthracene dendrimers containing up to 9 anthracene units are presented. In these dendrimers, anthracene-like absorption and emission properties are preserved due to the relatively weak electronic coupling between the anthracene units, while evidence of fast crosstalk within the molecular framework is still observed.
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| 8. |
- Börjesson, Karl, 1982, et al.
(författare)
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Photon up-conversion and molecular solar thermal energy storage: New materials and devices
- 2014
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Ingår i: 2014 IEEE Photonics Conference, IPC 2014. ; , s. 445-446
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Konferensbidrag (refereegranskat)abstract
- In a future society with limited access to fossil fuels, technologies for efficient on demand delivery of renewable energy are highly desirable. In this regard, methods that allow for solar energy storage and on demand solar driven energy generation are particularly relevant since the sun is the most abundant energy source.
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| 9. |
- Börjesson, Karl, 1982, et al.
(författare)
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Photon up-converting devices for solar fuels
- 2014
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Ingår i: SPIE Newsroom. - : SPIE-Intl Soc Optical Eng. - 1818-2259.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- Employing a molecular solution capable of triplet-triplet annihilation in a layered microfluidic device enables the solar spectrum to be locally modified toward the UV, increasing solar energy system efficiency.
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| 10. |
- Börjesson, Karl, 1982, et al.
(författare)
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Photon upconversion facilitated molecular solar energy storage
- 2013
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Ingår i: Journal of Materials Chemistry. - 1364-5501 .- 0959-9428. ; 1, s. 8521-8524
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Tidskriftsartikel (refereegranskat)abstract
- Photon upconversion is used to facilitate the production of a solar fuel. This is done by collocating a triplet–triplet annihilation upconversion system in a microfluidic device with a molecular solar thermal energy storage system. Incoherent truncated white light is used to drive the reaction and the green part of the spectrum is upconverted to blue light, which in turn is absorbed by the solar fuel.
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