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1.	Goldberg, Kristin, et al. (author) Oxadiazole isomers : all bioisosteres are not created equal 2012 In: MedChemComm. - : Royal Society of Chemistry (RSC). - 2040-2503 .- 2040-2511. ; 3:5, s. 600-604 Journal article (peer-reviewed)abstract Two series of amino-substituted 1,2,4- and 1,3,4-oxadiazole matched compounds were evaluated and found to have significant differences in their various physical and pharmaceutical properties. Experimental and computational techniques suggested that variation in hydrogen bond acceptor and donor strength were responsible for these effects.
2.	Scott, James S., et al. (author) Optimisation of aqueous solubility in a series of G protein coupled receptor 119 (GPR119) agonists 2013 In: MedChemComm. - : Royal Society of Chemistry (RSC). - 2040-2503 .- 2040-2511. ; 4:1, s. 95-100 Journal article (peer-reviewed)abstract Improving aqueous solubility is a challenge frequently faced within drug discovery programs. Herein we describe increases in solubility in two sub-series of GPR119 agonists through reduction of lipophilicity together with hydrogen bond acceptor modulation. Small molecule X-ray crystallography was utilised to investigate effects on solid state interactions.
3.	Kanai, M, et al. (author) 2023 swepub:Mat__t

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Brown, J. (1); Clark, A. (1); Cole, S. (1); Davies, M. (1); Endo, M. (1); Erdmann, J. (1); show more...; Fox, H. (1); George, S. (1); Hasegawa, Y. (1); Hughes, G. (1); Jackson, M. (1); Jackson, P. (1); Karthik, K. (1); Kirk, J. (1); Lee, H. (1); Lewis, A. (1); Maeno, T. (1); Saleem, M. (1); Stern, S. (1); Suzuki, Y. (1); Walker, R. (1); Watts, S. (1); White, S. (1); Williams, S. (1); Willis, C. (1); Wilson, A. (1); Wright, M. (1); Wu, Y. (1); Yamada, M. (1); Nagata, K. (1); Davidson, N. (1); Dobson, E. (1); Harvey, A. (1); Lange, C. (1); Oliveira, M. (1); Owen, S. (1); Rose, A. (1); Taylor, C. (1); Williams, E. (1); Davies, E. (1); Grau, N. (1); Haider, S. (1); Ryan, P. (1); Wright, C. (1); Tokunaga, K. (1); Suzuki, S (1); Gupta, A. (1); Robinson, M. (1); Dennis, C. (1); Marshall, R. (1); show less...

University: Royal Institute of Technology (2); Karolinska Institutet (1)

Language: English (3)

Research subject (UKÄ/SCB): Natural sciences (2)

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