| 1. |
- Mantini, Cesare, et al.
(author)
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A highly-detailed anatomical study of left atrial auricle as revealed by in-vivo computed tomography
- 2023
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In: Heliyon. - 2405-8440. ; 9:10
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Research review (peer-reviewed)abstract
- The left atrial auricle (LAA) is the main source of intracardiac thrombi, which contribute significantly to the total number of stroke cases. It is also considered a major site of origin for atrial fibrillation in patients undergoing ablation procedures. The LAA is known to have a high degree of morphological variability, with shape and structure identified as important contributors to thrombus formation. A detailed understanding of LAA form, dimension, and function is crucial for radiologists, cardiologists, and cardiac surgeons. This review describes the normal anatomy of the LAA as visualized through multiple imaging techniques such as computed tomography (CT), magnetic resonance imaging (MRI), and echocardiography. Special emphasis is devoted to a discussion on how the morphological characteristics of the LAA are closely related to the likelihood of developing LAA thrombi, including insights into LAA embryology.
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| 2. |
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| 3. |
- Mantini, Cesare, et al.
(author)
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Multi-modality Imaging Evaluation of a Rare and Complex Case of Single Ventricle Physiology; the important role of Cardiac MR
- 2022
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In: Acta bio-medica : Atenei Parmensis. - 0392-4203. ; 93:S1
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Journal article (peer-reviewed)abstract
- Congenital heart diseases (CHD) represent a major clinical and diagnostic challenge for correct abnormality identification and subsequent successful therapy; even more challenging is following-up patient health after multiple post-interventional corrections often required in complex cardio-vascular abnormalities. We describe a multi-modality imaging evaluation of a complex congenital cardio-vascular diseases, underlining the relevance of cardiac magnetic resonance to non invasively solve some issues related to postsurgical changes.
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| 4. |
- Mantini, Cesare, et al.
(author)
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Vieussens’ ring coronary collateral circulation : a natural bypass history
- 2022
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In: Acta Biomedica. - 0392-4203. ; 93
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Journal article (peer-reviewed)abstract
- “Vieussens’ ring” or “arterial circle of Vieussens” is a crucial hetero-coronaric pathway, bridging proximal right coronary artery (RCA) and left anterior descending artery (LAD) when a hemodynami-cally stenosis is established in the either of the vessel. In detail such coronary collateral circulation is usually supplied by branches of the conus artery. We present a case of a 62-year-old man who was admitted to our emergency department complaining of chest pain. Coronary angiography showed LAD occlusion at the mid tract with delayed and slight opacification of its distal segment sustained by Vieussens’ ring. Coronary computed tomography angiography (CCTA) was subsequently performed which confirmed the presence of such natural bypass and evaluated its relationship with adjacent structures. Imaging, particularly CCTA of-fers a valid tool in assessing the hetero-coronaric collateral vessel. Due to its high spatial resolution it may provide many information about the coronary anatomy by delineating their origin, course and termination. (www.actabiomedica.it).
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| 5. |
- Ruocco, Miriam, et al.
(author)
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m6A RNA Methylation in Marine Plants: First Insights and Relevance for Biological Rhythms
- 2020
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In: International Journal of Molecular Sciences. - : MDPI AG. - 1422-0067. ; 21:20
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Journal article (peer-reviewed)abstract
- Circadian regulations are essential for enabling organisms to synchronize physiology with environmental light-dark cycles. Post-transcriptional RNA modifications still represent an understudied level of gene expression regulation in plants, although they could play crucial roles in environmental adaptation. N6-methyl-adenosine (m6A) is the most prevalent mRNA modification, established by “writer” and “eraser” proteins. It influences the clockwork in several taxa, but only few studies have been conducted in plants and none in marine plants. Here, we provided a first inventory of m6A-related genes in seagrasses and investigated daily changes in the global RNA methylation and transcript levels of writers and erasers in Cymodocea nodosa and Zostera marina. Both species showed methylation peaks during the dark period under the same photoperiod, despite exhibiting asynchronous changes in the m6A profile and related gene expression during a 24-h cycle. At contrasting latitudes, Z. marina populations displayed overlapping daily patterns of the m6A level and related gene expression. The observed rhythms are characteristic for each species and similar in populations of the same species with different photoperiods, suggesting the existence of an endogenous circadian control. Globally, our results indicate that m6A RNA methylation could widely contribute to circadian regulation in seagrasses, potentially affecting the photo-biological behaviour of these plants.
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