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Search: WFRF:(Puschel F.)

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1.
  • Almanza, A., et al. (author)
  • Endoplasmic reticulum stress signalling - from basic mechanisms to clinical applications
  • 2019
  • In: Febs Journal. - : Wiley. - 1742-464X. ; 286:2, s. 241-278
  • Journal article (peer-reviewed)abstract
    • The endoplasmic reticulum (ER) is a membranous intracellular organelle and the first compartment of the secretory pathway. As such, the ER contributes to the production and folding of approximately one-third of cellular proteins, and is thus inextricably linked to the maintenance of cellular homeostasis and the fine balance between health and disease. Specific ER stress signalling pathways, collectively known as the unfolded protein response (UPR), are required for maintaining ER homeostasis. The UPR is triggered when ER protein folding capacity is overwhelmed by cellular demand and the UPR initially aims to restore ER homeostasis and normal cellular functions. However, if this fails, then the UPR triggers cell death. In this review, we provide a UPR signalling-centric view of ER functions, from the ER's discovery to the latest advancements in the understanding of ER and UPR biology. Our review provides a synthesis of intracellular ER signalling revolving around proteostasis and the UPR, its impact on other organelles and cellular behaviour, its multifaceted and dynamic response to stress and its role in physiology, before finally exploring the potential exploitation of this knowledge to tackle unresolved biological questions and address unmet biomedical needs. Thus, we provide an integrated and global view of existing literature on ER signalling pathways and their use for therapeutic purposes.
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2.
  • Mohammadi, Siawoosh, et al. (author)
  • Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?
  • 2019
  • In: Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?. ; 27
  • Conference paper (peer-reviewed)abstract
    • MRI-based biophysical models are typically validated by comparison to ex-vivo histology of fixed tissue. The fixation process itself and the accompanied autolysis processes strongly modify tissue composition, and lead to MR signal changes, making the validation of biophysical models for in vivo MRI particularly challenging. To better understand the temporal evolution of the fixation process within the whole brain and its influence on MRI parameters, we monitor the temporal evolution of the fixation process of a whole human post-mortem brain using the linear relaxometry model across 15 time-points comprised of one unfixed, in-situ MRI scan and 14 ex-vivo MRI scans at different stages of the fixation process (days 1-93).
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