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- Coppo, Rosanna, et al.
(author)
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Is there long-term value of pathology scoring in immunoglobulin A nephropathy? : A validation study of the Oxford Classification for IgA Nephropathy (VALIGA) update
- 2020
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In: Nephrology, Dialysis and Transplantation. - : Oxford University Press (OUP). - 0931-0509 .- 1460-2385. ; 35:6, s. 1002-1009
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Journal article (peer-reviewed)abstract
- Background: It is unknown whether renal pathology lesions in immunoglobulin A nephropathy (IgAN) correlate with renal outcomes over decades of follow-up.Methods: In 1130 patients of the original Validation Study of the Oxford Classification for IgA Nephropathy (VALIGA) cohort, we studied the relationship between the MEST score (mesangial hypercellularity, M; endocapillary hypercellularity, E; segmental glomerulosclerosis, S; tubular atrophy/interstitial fibrosis, T), crescents (C) and other histological lesions with both a combined renal endpoint [50% estimated glomerular filtration rate (eGFR) loss or kidney failure] and the rate of eGFR decline over a follow-up period extending to 35 years [median 7 years (interquartile range 4.1-10.8)].Results: In this extended analysis, M1, S1 and T1-T2 lesions as well as the whole MEST score were independently related with the combined endpoint (P < 0.01), and there was no effect modification by age for these associations, suggesting that they may be valid in children and in adults as well. Only T lesions were associated with the rate of eGFR loss in the whole cohort, whereas C showed this association only in patients not treated with immunosuppression. In separate prognostic analyses, the whole set of pathology lesions provided a gain in discrimination power over the clinical variables alone, which was similar at 5 years (+2.0%) and for the whole follow-up (+1.8%). A similar benefit was observed for risk reclassification analyses (+2.7% and +2.4%).Conclusion: Long-term follow-up analyses of the VALIGA cohort showed that the independent relationship between kidney biopsy findings and the risk of progression towards kidney failure in IgAN remains unchanged across all age groups and decades after the renal biopsy.
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- Lloyd-Smith, Anika, et al.
(author)
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Heritage language proficiency does not predict syntactic CLI into L3 English
- 2021
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In: International Journal of Bilingual Education and Bilingualism. - : Informa UK Limited. - 1367-0050 .- 1747-7522. ; 24:3, s. 435-451
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Journal article (peer-reviewed)abstract
- This study examines cross-linguistic influence (CLI) in the acquisition of embedded wh-questions in L3 English in German-dominant heritage speakers (HSs) of Italian. Specifically, we investigate whether a higher proficiency in the heritage language Italian increases the potential for CLI from that language. To this end, 21 adult-aged Italian-German early bilinguals and 32 monolingual controls (L1 speakers of Italian, German, or English) completed an acceptability judgement task that tested the acquisition of embedded wh-questions in English (while also controlling for the acquisition of the relevant properties in German and Italian). Language dominance was assessed using a yes/no vocabulary test and a proficiency index based on various aspects of self-reported language use and proficiency. Our results suggest that syntactic CLI occurs from both languages and that this is unrelated to overall dominance in German or proficiency in Italian.
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