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  • Rahman-Roblick, R., et al. (author)
  • Proteomic identification of p53-dependent protein phosphorylation
  • 2008
  • In: Oncogene. - : Springer Science and Business Media LLC. - 0950-9232 .- 1476-5594. ; 27:35, s. 4854-4859
  • Journal article (peer-reviewed)abstract
    • The p53 tumor suppressor regulates transcription of target genes. We have previously analysed the p53-dependent proteome and identified novel protein targets. Here we have examined p53-dependent phosphorylation using two-dimensional gel electrophoresis and staining with the fluorescent phosphoprotein dye Pro-Q Diamond. We report that p53 induces phosphorylation of a subset of proteins including Nm23, DJ-1, ANXA1 and PrxII. Our identification of p53-dependent phosphorylation of specific target proteins reveals new aspects of the p53-dependent cellular response and suggests that such posttranslational modifications may contribute to p53-mediated tumor suppression.
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  • Result 1-1 of 1
Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Becker, S. (1)
Hellman, Ulf (1)
Auer, G (1)
Wiman, K. G. (1)
Rahman-Roblick, R. (1)
Bader, F.G. (1)
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Roblick, U.J. (1)
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University
Uppsala University (1)
Karolinska Institutet (1)
Language
English (1)
Year
2008 (1)

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