| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Buchner, F. L., et al.
(author)
-
Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- 2010
-
In: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 1573-7225 .- 0957-5243. ; 21:3, s. 357-371
-
Journal article (peer-reviewed)abstract
- Objective To examine the association between fruit and vegetable consumption and risk of different histological subtypes of lung cancer among participants of the European Prospective Investigation into Cancer and Nutrition study. Methods Multivariable Cox proportional hazard models were used to analyze the data. A calibration study in a subsample was used to reduce dietary measurement errors. Results During a mean follow-up of 8.7 years, 1,830 incident cases of lung cancer (574 adenocarcinoma, 286 small cell, 137 large cell, 363 squamous cell, 470 other histologies) were identified. In line with our previous conclusions, we found that after calibration a 100 g/day increase in fruit and vegetables consumption was associated with a reduced lung cancer risk (HR 0.94; 95% CI 0.89-0.99). This was also seen among current smokers (HR 0.93; 95% CI 0.90-0.97). Risks of squamous cell carcinomas in current smokers were reduced for an increase of 100 g/day of fruit and vegetables combined (HR 0.85; 95% CI 0.76-0.94), while no clear effects were seen for the other histological subtypes. Conclusion We observed inverse associations between the consumption of vegetables and fruits and risk of lung cancer without a clear effect on specific histological subtypes of lung cancer. In current smokers, consumption of vegetables and fruits may reduce lung cancer risk, in particular the risk of squamous cell carcinomas.
|
|
| 5. |
- Eidevåg, Tobias, 1987, et al.
(author)
-
Collisional damping of spherical ice particles
- 2021
-
In: Powder Technology. - : Elsevier BV. - 0032-5910 .- 1873-328X. ; 383, s. 318-327
-
Journal article (peer-reviewed)abstract
- This paper presents experimental values for the coefficient of restitution (e(n)) for millimeter-sized ice particles colliding with massive walls at different temperatures. Three different wall materials are tested: hardened glass, ice and Acrylonitrile butadiene styrene (ABS) polymer. The results show a high sensitivity to impact velocity V-i, where e(n) decreases rapidly with increasing V-i. The results also show a decrease in e(n) with increasing temperature T. A novel model that predicts e(n) based on the assumption of collisional melting and viscous damping caused by an increased premelted liquid-layer, is proposed. The model predicts both the velocity and the temperature trends seen in the experiments. The difference obtained in experiments between wall materials is also captured by the new model. A generalized regime map for ice particle collisions is proposed to combine the new model with previous work. (C) 2021 The Author(s).
|
|
| 6. |
|
|
| 7. |
- Ström, Daniel, 1971, et al.
(author)
-
A new device for coating single particles under controlled conditions
- 2005
-
In: Chemical Engineering Science. - : Elsevier BV. - 0009-2509. ; 60, s. 4647-4653
-
Journal article (peer-reviewed)abstract
- A new device for coating a single levitated particle in a controllable environment is designed and tested. This enables fluidized bed processing to be simulated experimentally on a single-particle level. The device consists of a coating chamber, which contains a capillary tube for levitating the particle, a micro-dispenser for producing discrete drops of controlled size and velocity and a device for supplying gas with specified temperature and humidity. The coating chamber consists of two parts, a confined space where the particle is levitated and a droplet insertion cone where the coating solution is injected into the particle suspending gas flow. A capillary with a well-defined diameter connects the droplet insertion cone and the area where the particle is levitated. The device is equipped with a piezo-actuated flow-through micro-dispenser that has the ability to produce discrete droplets with high reproducibility in terms of droplet size and velocity. The gas required for the coating process is taken from a gas container where the water content is analysed and kept at a minimum. A liquid flow is then introduced into the gas flow at a well-defined flow rate, mixed and evaporated in a three-way mixing vault. The humidified gas flow is then split into two separate flows; a suspending gas flow and a protecting gas flow for the inside of the coating chamber. The device is equipped with a high-speed video camera for monitoring both droplet production and droplet impact. Temperatures and flow rates throughout the device are measured and logged. Preliminary results show the influence of solvent, gas quality and coating procedure on the quality of the coating.
|
|
| 8. |
|
|
| 9. |
- Tierney, T. B., et al.
(author)
-
Investigation of the Particle Growth of Fenofibrate following Antisolvent Precipitation and Freeze-Drying
- 2015
-
In: Crystal Growth & Design. - : American Chemical Society (ACS). - 1528-7483 .- 1528-7505. ; 15:11, s. 5213-5222
-
Journal article (peer-reviewed)abstract
- Submicron to small-micron-sized particles of the hydrophobic drug, fenofibrate, were prepared by controlled crystallization in order to influence its dissolution behavior. An antisolvent precipitation process successfully generated particles (200−300 nm) which matched the size and dissolution behavior of a commercial wet-milled formulation of the drug. Although the preparation of submicron-sized particles was straightforward, retaining their size in suspension and during isolation was a challenge. Additives were employed to temporarily stabilize the suspension, and extend the time window for isolation of the submicron particles. Precipitated particles were isolated primarily by immediate freeze−drying, but drying stresses were found to destabilize the fragile submicron system. The growth pathway of particles in suspension and during oven and freeze−drying were compared. Although the growth pathways appeared considerably different from a visual morphological perspective, an investigation of the electron diffraction patterns and the inner-particle surfaces showed that the growth pathways were the same: molecular addition by Ostwald ripening. The observed differences in the time-resolved particle morphologies were found to be a result of the freeze−drying process.
|
|
| 10. |
|
|
