| 1. |
- Bellm, Eric C., et al.
(author)
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The Zwicky Transient Facility : System Overview, Performance, and First Results
- 2019
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In: Publications of the Astronomical Society of the Pacific. - : IOP Publishing. - 0004-6280 .- 1538-3873. ; 131:995
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Journal article (peer-reviewed)abstract
- The Zwicky Transient Facility (ZTF) is a new optical time-domain survey that uses the Palomar 48 inch Schmidt telescope. A custom-built wide-field camera provides a 47 deg(2) field of view and 8 s readout time, yielding more than an order of magnitude improvement in survey speed relative to its predecessor survey, the Palomar Transient Factory. We describe the design and implementation of the camera and observing system. The ZTF data system at the Infrared Processing and Analysis Center provides near-real-time reduction to identify moving and varying objects. We outline the analysis pipelines, data products, and associated archive. Finally, we present on-sky performance analysis and first scientific results from commissioning and the early survey. ZTF's public alert stream will serve as a useful precursor for that of the Large Synoptic Survey Telescope.
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| 2. |
- Bellm, Johannes, et al.
(author)
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Herwig 7.2 release note
- 2020
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In: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 80:5
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Journal article (peer-reviewed)abstract
- A new release of the Monte Carlo event generator Herwig (version 7.2) is now available. This version introduces a number of improvements over the major version 7.0, notably: multi-jet merging with the dipole shower at LO and NLO QCD; spin correlations in both the dipole and angular-ordered parton showers; an improved choice of evolution variable in the angular-ordered parton shower; improvements to mass effects and top decays in the dipole shower, improvements to the simulation of multiple-parton interactions, including diffractive processes; a new model for baryonic colour reconnection; improvements to strangeness production; as well as a new tune of the hadronisation parameters and support for generic Lorentz structures in BSM models. This article illustrates new features of versions 7.1 and 7.2.
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| 3. |
- Lafaye, Remi, et al.
(author)
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Measuring the Higgs Sector
- 2009
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In: Journal of High Energy Physics (JHEP). - : Springer Science and Business Media LLC. - 1126-6708 .- 1029-8479. ; :8, s. 009-
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Journal article (peer-reviewed)abstract
- If we find a light Higgs boson at the LHC, there should be many observable channels which we can exploit to measure the relevant parameters in the Higgs sector. We use the SFitter framework to map these measurements on the parameter space of a general weak-scale effective theory with a light Higgs state of mass 120GeV. Our analysis benefits from the parameter determination tools and the error treatment used in new-physics searches, to study individual parameters and their error bars as well as parameter correlations.
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| 4. |
- Adam, Claire, et al.
(author)
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Measuring Unification
- 2011
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In: European Physical Journal C. - : Springer. - 1434-6044 .- 1434-6052. ; 71:1, s. 1-19
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Journal article (peer-reviewed)abstract
- If supersymmetry is observed at the LHC its model parameters can be measured at the electroweak scale. We discuss the expected precision on the parameter determination, including a proper treatment of experimental and theoretical errors. Particular attention is paid to degenerate solutions. Using the SFitter framework we perform a bottom-up reconstruction of the unified parameters at the high scale, including a full error propagation.
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| 5. |
- Bock, Sebastian, et al.
(author)
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Measuring Hidden Higgs and Strongly-Interacting Higgs Scenarios
- 2010
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In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 694:1, s. 44-53
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Journal article (peer-reviewed)abstract
- Higgs couplings can be affected by physics beyond the Standard Model We study modifications through interactions with a hidden sector and in specific composite Higgs models accessible at the LHC Both scenarios give rise to congruent patterns of universal or partially universal shifts In addition Higgs decays to the hidden sector may lead to invisible decay modes which we also exploit Experimental bounds on such potential modifications will measure the concordance of an observed Higgs boson with the Standard Model
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| 6. |
- Brakebusch, Cord, et al.
(author)
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Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory
- 2002
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In: Molecular and Cellular Biology. - 0270-7306. ; 22:21, s. 7417-7427
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Journal article (peer-reviewed)abstract
- Brevican is a brain-specific proteoglycan which is found in specialized extracellular matrix structures called perineuronal nets. Brevican increases the invasiveness of glioma cells in vivo and has been suggested to play a role in central nervous system fiber tract development. To study the role of brevican in the development and function of the brain, we generated mice lacking a functional brevican gene. These mice are viable and fertile and have a normal life span. Brain anatomy was normal, although alterations in the expression of neurocan were detected. Perineuronal nets formed but appeared to be less prominent in mutant than in wild-type mice. Brevican-deficient mice showed significant deficits in the maintenance of hippocampal long-term potentiation (LTP). However, no obvious impairment of excitatory and inhibitory synaptic transmission was found, suggesting a complex cause for the LTP defect. Detailed behavioral analysis revealed no statistically significant deficits in learning and memory. These data indicate that brevican is not crucial for brain development but has restricted structural and functional roles.
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| 7. |
- Cable, Jennifer, et al.
(author)
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Progress in vaccine development for infectious diseases : a Keystone Symposia report
- 2023
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In: Annals of the New York Academy of Sciences. - : John Wiley & Sons. - 0077-8923 .- 1749-6632. ; 1524:1, s. 65-86
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Journal article (peer-reviewed)abstract
- The COVID-19 pandemic has taught us many things, among the most important of which is that vaccines are one of the cornerstones of public health that help make modern longevity possible. While several different vaccines have been successful at stemming the morbidity and mortality associated with various infectious diseases, many pathogens/diseases remain recalcitrant to the development of effective vaccination. Recent advances in vaccine technology, immunology, structural biology, and other fields may yet yield insight that will address these diseases; they may also help improve societies' preparedness for future pandemics. On June 1-4, 2022, experts in vaccinology from academia, industry, and government convened for the Keystone symposium "Progress in Vaccine Development for Infectious Diseases" to discuss state-of-the-art technologies, recent advancements in understanding vaccine-mediated immunity, and new aspects of antigen design to aid vaccine effectiveness.
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| 8. |
- Campanario, Francisco, et al.
(author)
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Stress testing the vector-boson-fusion approximation in multijet final states
- 2018
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In: Physical Review D. - 2470-0010. ; 98:3
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Journal article (peer-reviewed)abstract
- We consider electroweak Higgs plus three jets production at NLO QCD beyond strict VBF acceptance cuts. We investigate, for the first time, how accurate the VBF approximation is in these regions and within perturbative uncertainties by a detailed comparison of full and approximate calculations. We find that a rapidity gap between the tagging jets guarantees a good approximation, while an invariant mass cut alone is not sufficient, which needs to be confronted with experimental choices. We also find that a significant part of the QCD corrections can be attributed to Higgs-Strahlungs-type topologies.
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| 9. |
- Fenstermacher, M.E., et al.
(author)
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DIII-D research advancing the physics basis for optimizing the tokamak approach to fusion energy
- 2022
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In: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 62:4
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Journal article (peer-reviewed)abstract
- DIII-D physics research addresses critical challenges for the operation of ITER and the next generation of fusion energy devices. This is done through a focus on innovations to provide solutions for high performance long pulse operation, coupled with fundamental plasma physics understanding and model validation, to drive scenario development by integrating high performance core and boundary plasmas. Substantial increases in off-axis current drive efficiency from an innovative top launch system for EC power, and in pressure broadening for Alfven eigenmode control from a co-/counter-I p steerable off-axis neutral beam, all improve the prospects for optimization of future long pulse/steady state high performance tokamak operation. Fundamental studies into the modes that drive the evolution of the pedestal pressure profile and electron vs ion heat flux validate predictive models of pedestal recovery after ELMs. Understanding the physics mechanisms of ELM control and density pumpout by 3D magnetic perturbation fields leads to confident predictions for ITER and future devices. Validated modeling of high-Z shattered pellet injection for disruption mitigation, runaway electron dissipation, and techniques for disruption prediction and avoidance including machine learning, give confidence in handling disruptivity for future devices. For the non-nuclear phase of ITER, two actuators are identified to lower the L-H threshold power in hydrogen plasmas. With this physics understanding and suite of capabilities, a high poloidal beta optimized-core scenario with an internal transport barrier that projects nearly to Q = 10 in ITER at ∼8 MA was coupled to a detached divertor, and a near super H-mode optimized-pedestal scenario with co-I p beam injection was coupled to a radiative divertor. The hybrid core scenario was achieved directly, without the need for anomalous current diffusion, using off-axis current drive actuators. Also, a controller to assess proximity to stability limits and regulate β N in the ITER baseline scenario, based on plasma response to probing 3D fields, was demonstrated. Finally, innovative tokamak operation using a negative triangularity shape showed many attractive features for future pilot plant operation.
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| 10. |
- Huang, Lam O., et al.
(author)
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Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities
- 2021
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In: Nature Metabolism. - : Springer Nature. - 2522-5812. ; 3:2, s. 228-243
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Journal article (peer-reviewed)abstract
- Obesity is a major risk factor for cardiometabolic diseases. Nevertheless, a substantial proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The mechanisms that uncouple adiposity from its cardiometabolic complications are not fully understood. Here, we identify 62 loci of which the same allele is significantly associated with both higher adiposity and lower cardiometabolic risk. Functional analyses show that the 62 loci are enriched for genes expressed in adipose tissue, and for regulatory variants that influence nearby genes that affect adipocyte differentiation. Genes prioritized in each locus support a key role of fat distribution (FAM13A, IRS1 and PPARG) and adipocyte function (ALDH2, CCDC92, DNAH10, ESR1, FAM13A, MTOR, PIK3R1 and VEGFB). Several additional mechanisms are involved as well, such as insulin-glucose signalling (ADCY5, ARAP1, CREBBP, FAM13A, MTOR, PEPD, RAC1 and SH2B3), energy expenditure and fatty acid oxidation (IGF2BP2), browning of white adipose tissue (CSK, VEGFA, VEGFB and SLC22A3) and inflammation (SH2B3, DAGLB and ADCY9). Some of these genes may represent therapeutic targets to reduce cardiometabolic risk linked to excess adiposity.
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