| 1. |
- Lumsden, A, et al.
(author)
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Neurobiology.
- 2001
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In: Current Opinion in Neurobiology. - 0959-4388 .- 1873-6882. ; 11:3, s. 259-66
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Research review (peer-reviewed)
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| 2. |
- Jutzi, D, et al.
(author)
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Aberrant interaction of FUS with the U1 snRNA provides a molecular mechanism of FUS induced amyotrophic lateral sclerosis
- 2020
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 11:1, s. 6341-
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Journal article (peer-reviewed)abstract
- Mutations in the RNA-binding protein Fused in Sarcoma (FUS) cause early-onset amyotrophic lateral sclerosis (ALS). However, a detailed understanding of central RNA targets of FUS and their implications for disease remain elusive. Here, we use a unique blend of crosslinking and immunoprecipitation (CLIP) and NMR spectroscopy to identify and characterise physiological and pathological RNA targets of FUS. We find that U1 snRNA is the primary RNA target of FUS via its interaction with stem-loop 3 and provide atomic details of this RNA-mediated mode of interaction with the U1 snRNP. Furthermore, we show that ALS-associated FUS aberrantly contacts U1 snRNA at the Sm site with its zinc finger and traps snRNP biogenesis intermediates in human and murine motor neurons. Altogether, we present molecular insights into a FUS toxic gain-of-function involving direct and aberrant RNA-binding and strengthen the link between two motor neuron diseases, ALS and spinal muscular atrophy (SMA).
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| 5. |
- Miller, Rachael, et al.
(author)
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Socio-ecological correlates of neophobia in corvids
- 2022
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In: Current Biology. - : Elsevier BV. - 0960-9822. ; 32:1, s. 4-85
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Journal article (peer-reviewed)abstract
- Behavioral responses to novelty, including fear and subsequent avoidance of novel stimuli, i.e., neophobia, determine how animals interact with their environment. Neophobia aids in navigating risk and impacts on adaptability and survival. There is variation within and between individuals and species; however, lack of large-scale, comparative studies critically limits investigation of the socio-ecological drivers of neophobia. In this study, we tested responses to novel objects and food (alongside familiar food) versus a baseline (familiar food alone) in 10 corvid species (241 subjects) across 10 labs worldwide. There were species differences in the latency to touch familiar food in the novel object and novel food conditions relative to the baseline. Four of seven socio-ecological factors influenced object neophobia: (1) use of urban habitat (versus not), (2) territorial pair versus family group sociality, (3) large versus small maximum flock size, and (4) moderate versus specialized caching (whereas range, hunting live animals, and genus did not), while only maximum flock size influenced food neophobia. We found that, overall, individuals were temporally and contextually repeatable (i.e., consistent) in their novelty responses in all conditions, indicating neophobia is a stable behavioral trait. With this study, we have established a network of corvid researchers, demonstrating potential for further collaboration to explore the evolution of cognition in corvids and other bird species. These novel findings enable us, for the first time in corvids, to identify the socio-ecological correlates of neophobia and grant insight into specific elements that drive higher neophobic responses in this avian family group. Video abstract: [Figure presented]
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| 6. |
- Muzet, V, et al.
(author)
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Review of road surface photometry methods and devices – Proposal for new measurement geometries
- 2021
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In: Lighting Research and Technology. - : SAGE Publications Ltd STM. - 1477-1535 .- 1477-0938. ; 53:3, s. 213-229
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Journal article (peer-reviewed)abstract
- Specifications concerning road lighting and photometry of road surfaces were established more than 50 years ago. Road lighting design and road marking visibility were developed for vehicle driving. The observation distance defined by standards corresponds to interurban applications; however, within Europe these areas do not tend to be lit. The objective of the SURFACE project is to propose new geometries for the photometric characterisation of pavements, both adapted to different urban travel modes and new lighting technologies. This article reviews the available guidelines, standards, measuring devices and literature regarding geometries and road lighting applications, and presents the project SURFACE analysis and proposal. The SURFACE consortium recommends adding several new angles for different driving conditions and road users; 2.29° for urban environments and consistency with road marking standard, and 1° for extra-urban environment and consistency with previous geometries. A 5° angle, corresponding to 17-m viewing distance, could be an interesting compromise, suitable for urban driving at low speed, cycling and for scooters. The angles of 10° and 20° are under consideration for describing the boundary between diffuse and specular behaviour.
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| 7. |
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| 8. |
- Reber, A, et al.
(author)
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The expression and impact of antifungal grooming in ants.
- 2011
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In: Journal of Evolutionary Biology. - : Wiley. - 1010-061X .- 1420-9101. ; 24:5, s. 954-64
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Journal article (peer-reviewed)abstract
- Parasites can cause extensive damage to animal societies in which many related individuals frequently interact. In response, social animals have evolved diverse individual and collective defences. Here, we measured the expression and efficiency of self-grooming and allo-grooming when workers of the ant Formica selysi were contaminated with spores of the fungal entomopathogen Metarhizium anisopliae. The amount of self-grooming increased in the presence of fungal spores, which shows that the ants are able to detect the risk of infection. In contrast, the amount of allo-grooming did not depend on fungal contamination. Workers groomed all nestmate workers that were re-introduced into their groups. The amount of allo-grooming towards noncontaminated individuals was higher when the group had been previously exposed to the pathogen. Allo-grooming decreased the number of fungal spores on the surface of contaminated workers, but did not prevent infection in the conditions tested (high dose of spores and late allo-grooming). The rate of disease transmission to groomers and other nestmates was extremely low. The systematic allo-grooming of all individuals returning to the colony, be they contaminated or not, is probably a simple but robust prophylactic defence preventing the spread of fungal diseases in insect societies.
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