| 1. |
- Remus, A., et al.
(author)
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A core outcome set for research and clinical practice in women with pelvic girdle pain: PGP-COS
- 2021
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 16:2
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Journal article (peer-reviewed)abstract
- Background Inconsistent reporting of outcomes in clinical trials of women with Pelvic Girdle Pain (PGP) hinders comparison of findings and the reliability of evidence synthesis. A core outcome set (COS) can address this issue as it defines a minimum set of outcomes that should be reported in all clinical trials on the condition. The aim of this study was to develop a consensus-based COS for evaluating the effectiveness of interventions in PGP during pregnancy and postpartum for use in research and clinical practice. Methods A systematic review of previous studies on PGP and semi-structured interviews with women were undertaken to identify all outcomes that were reported in prior studies and that are relevant to those experiencing the condition. Key stakeholders (clinicians, researchers, service providers/policy makers and individuals with PGP) then rated the importance of these outcomes for including in a preliminary PGP-COS using a 3-round Delphi study. The final COS was agreed at a face-to-face consensus meeting. Results Consensus was achieved on five outcomes for inclusion in the final PGP-COS. All outcomes are grouped under the "life impact" domain and include: pain frequency, pain intensity/severity, function/disability/activity limitation, health-related quality of life and fear avoidance. Conclusion This study identified a COS for evaluating the effectiveness of interventions in pregnancy-related and postpartum-related PGP in research and clinical settings. It is advocated that all trials, other non-randomised studies and clinicians in this area use this COS by reporting these outcomes as a minimum. This will ensure the reporting of meaningful outcomes and will enable the findings of future studies to be compared and combined. Future work will determine how to measure the outcomes of the PGP-COS. Core outcome set registration This PGP-COS was registered with COMET (Core Outcome Measures for Effectiveness Trials) in January 2017 (http://www.comet-initiative.org/studies/details/958).
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| 2. |
- Davies, James S., et al.
(author)
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Structure and mechanism of a tripartite ATP-independent periplasmic TRAP transporter
- 2023
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
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Journal article (peer-reviewed)abstract
- In bacteria and archaea, tripartite ATP-independent periplasmic (TRAP) transporters uptake essential nutrients. TRAP transporters receive their substrates via a secreted soluble substrate-binding protein. How a sodium ion-driven secondary active transporter is strictly coupled to a substrate-binding protein is poorly understood. Here we report the cryo-EM structure of the sialic acid TRAP transporter SiaQM from Photobacterium profundum at 2.97 Å resolution. SiaM comprises a “transport” domain and a “scaffold” domain, with the transport domain consisting of helical hairpins as seen in the sodium ion-coupled elevator transporter VcINDY. The SiaQ protein forms intimate contacts with SiaM to extend the size of the scaffold domain, suggesting that TRAP transporters may operate as monomers, rather than the typically observed oligomers for elevator-type transporters. We identify the Na+ and sialic acid binding sites in SiaM and demonstrate a strict dependence on the substrate-binding protein SiaP for uptake. We report the SiaP crystal structure that, together with docking studies, suggest the molecular basis for how sialic acid is delivered to the SiaQM transporter complex. We thus propose a model for substrate transport by TRAP proteins, which we describe herein as an ‘elevator-with-an-operator’ mechanism.
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| 3. |
- North, Rachel A, et al.
(author)
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"Just a spoonful of sugar...": import of sialic acid across bacterial cell membranes
- 2018
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In: Biophysical reviews. - : Springer Science and Business Media LLC. - 1867-2450 .- 1867-2469. ; 10:2, s. 219-227
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Research review (peer-reviewed)abstract
- Eukaryotic cell surfaces are decorated with a complex array of glycoconjugates that are usually capped with sialic acids, a large family of over 50 structurally distinct nine-carbon amino sugars, the most common member of which is N-acetylneuraminic acid. Once made available through the action of neuraminidases, bacterial pathogens and commensals utilise host-derived sialic acid by degrading it for energy or repurposing the sialic acid onto their own cell surface to camouflage the bacterium from the immune system. A functional sialic acid transporter has been shown to be essential for the uptake of sialic acid in a range of human bacterial pathogens and important for host colonisation and persistence. Here, we review the state-of-play in the field with respect to the molecular mechanisms by which these bio-nanomachines transport sialic acids across bacterial cell membranes.
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| 4. |
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| 5. |
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Control modes versus control styles: Investigating isd project control effects at the individual level
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Editorial proceedings (peer-reviewed)abstract
- Most previous research on ISD project control conceptualizes control activities in terms of control modes and focuses on performance effects at the project level. This seems to oversimplify the way controls 'work' by neglecting the multidimensionality of control activities and their effects at the individual level. In this paper, we adopt an expanded view of ISD project control, employing data from 92 ISD projects to analyze how different control modes (what?) and control styles (how?) relate to controllee task performance and job satisfaction. Importantly, our results suggest that control style is more important than control modes in explaining individual-level control effects. Moreover, as hypothesized, formal and informal controls positively affect task performance, while only informal controls have a positive effect on job satisfaction. Finally, we find significant interaction effects between control style and formal controls, suggesting a complex non-linear relationship between the two, which opens interesting avenues for future research.
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| 6. |
- Mähring, Magnus, et al.
(author)
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Control configuration and control enactment in information systems projects: Review and expanded theoretical framework
- 2016
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In: MIS Quarterly. - : University of Minnesota, Management Information Systems Research Center. - 0276-7783. ; 40:3, s. 741-774
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Journal article (peer-reviewed)abstract
- The control of information systems (IS) projects is a key activity for deployment of information technology (IT) resources and ultimately for value creation through IT. For the last 20 years, research on IS project control has grown to cover a wide range of aspects and issues, including control modes, amounts, and portfolios, control in internal and outsourced settings, and control antecedents, consequences, and dynamics. There is an important theoretical and practical impetus for this research, since the nature of IS projects creates specific and challenging conditions for control, and since control research in neighboring disciplines often neglects temporary endeavors such as projects. In this study, we provide a systematic review and synthesis of the literature and develop an expanded theoretical framework for IS project control with supporting conjectures. Our review reveals that existing research primarily studies the contextual antecedents and performance consequences of control modes and amounts, and thus focuses on control portfolio configurations (what). In contrast, prior research largely neglects control enactment, that is, how the controller interacts with the controllee to put the portfolio of controls into practice. Our expanded framework points to the importance of studying control portfolio configurations and control enactment (in terms of control style and control congruence) in combination, in order to better understand IS project control effectiveness. Expanding the toolbox of concepts available to IS researchers, our framework helps resolve existing research gaps and inconsistencies, and opens up new avenues for future research on the control of IS projects.
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| 7. |
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| 8. |
- Pereira, H. A., et al.
(author)
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Capacitor voltage balance performance comparison of MMC-STATCOM using NLC and PS-PWM strategies during negative sequence current injection
- 2016
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In: 18th European Conference on Power Electronics and Applications, EPE 2016 ECCE Europe, Karlsruhe, Germany, 5-9 September 2016. - 2325-0313. - 9789075815245
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Conference paper (peer-reviewed)abstract
- This paper addresses the modular multilevel converter applied as a static synchronous compensator. The main objective of this work is to compare the converter performance considering two different submodule capacitor voltage balancing strategies: nearest level control and phase-shifted pulse width modulation, during positive and negative sequence current injection. Results of a 15 MVA MMC STATCOM show that the nearest level control strategy has lower average switching frequency compared to the phase-shifted pulse width modulation strategy, considering comparable submodule capacitance voltage ripple.
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| 9. |
- Remus, Ulrich, et al.
(author)
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Control Modes Versus Control Styles: Investigating ISD Project Control Effects at the Individual Level
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Conference paper (other academic/artistic)abstract
- Most previous research on ISD project control conceptualizes control activities in terms of control modes and focuses on performance effects at the project level. This seems to oversimplify the way controls ‘work’ by neglecting the multidimensionality of control activities and their effects at the individual level. In this paper, we adopt an expanded view of ISD project control, employing data from 92 ISD projects to analyze how different control modes (what?) and control styles (how?) relate to controllee task performance and job satisfaction. Importantly, our results suggest that control style is more important than control modes in explaining individual-level control effects. Moreover, as hypothesized, formal and informal controls positively affect task performance, while only informal controls have a positive effect on job satisfaction. Finally, we find significant interaction effects between control style and formal controls, suggesting a complex non-linear relationship between the two, which opens interesting avenues for future research.
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| 10. |
- Remus, Ulrich, et al.
(author)
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Why do you control? The concept of control purpose and its implications for is project control research
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Conference paper (other academic/artistic)abstract
- Existing IS project control research primarily draws on agency theory to conceptualize control, relating control closely to aligning behaviors of self-interested controllees with organizational objectives. Recent studies in neighboring disciplines, however, suggest that the agency view of control is too narrow to fully understand control activities. Informed by these studies as well as drawing on stewardship and coordination theory, we introduce the concept of control purpose to the IS literature. We define this concept as the intentions underlying the controller's control activities, and distinguish between appropriation-And coordination-oriented controls. To evaluate the control purpose concept, we conduct a secondary analysis of 21 IS project control case studies. Results show that, despite their stated agency focus, most studies report on controls addressing both appropriation concerns and coordination requirements. On this basis, we discuss two potential research areas, knowledge management and control dynamics, where the control purpose concept can offer novel insights.
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