| 1. |
- de Jong, Yde, et al.
(author)
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PESI - a taxonomic backbone for Europe
- 2015
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In: Biodiversity Data Journal. - 1314-2836 .- 1314-2828. ; 3, s. 1-51
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Journal article (peer-reviewed)abstract
- Reliable taxonomy underpins communication in all of biology, not least nature conservation and sustainable use of ecosystem resources. The flexibility of taxonomic interpretations, however, presents a serious challenge for end-users of taxonomic concepts. Users need standardised and continuously harmonised taxonomic reference systems, as well as high-quality and complete taxonomic data sets, but these are generally lacking for non-specialists. The solution is in dynamic, expertly curated web-based taxonomic tools.The Pan-European Species-directories Infrastructure (PESI) worked to solve this key issue by providing a taxonomic e-infrastructure for Europe. It strengthened the relevant social (expertise) and information (standards, data and technical) capacities of five major community networks on taxonomic indexing in Europe, which is essential for proper biodiversity assessment and monitoring activities. The key objectives of PESI were: 1) standardisation in taxonomic reference systems, 2) enhancement of the quality and completeness of taxonomic data sets and 3) creation of integrated access to taxonomic information.This paper describes the results of PESI and its future prospects, including the involvement in major European biodiversity informatics initiatives and programs.
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| 2. |
- Asproth, Viveca, 1948-, et al.
(author)
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Accessibility in Crisis Management
- 2011
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In: European Sociological Association Research Network 22 Sociology of Risk and Uncertainty RISK, UNCERTAINTY AND POLICY Midterm Conference 2011.
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Conference paper (peer-reviewed)
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| 3. |
- Asproth, Viveca, 1948-, et al.
(author)
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Simulation of Accessibility in Crisis Management
- 2014
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In: International Journal of Computing Anticipatory Systems. - Liege, Belgium. - 1373-5411. ; 30, s. 93-103
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Journal article (peer-reviewed)abstract
- To route the rescue service, the police and the ambulance during an emergency event,the command and control units need information about accessibility. When twocountries are involved in the rescue work there is also a possibility to send rescue helpfrom either country, which complicates the situation but of course gives a greatopportunity. Good predictions for when rescue service are to appear at the scene of theemergency and from where to send them are of great importance. Different actions areto be taken due to the waiting time. Accessibility is a complex term which is furtherelaborated and conceptualized in the paper. The paper also presents tentative results forhow to conceptualize and simulate accessibility in this crisis management setting. Theresults are based on empirical data from the region involved in the GSS project.
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| 4. |
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| 5. |
- Bauer, Friederike U., et al.
(author)
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Tracing the exhumation history of the Rwenzori Mountains, Albertine Rift, Uganda, using low-temperature thermochronology
- 2013
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In: Tectonophysics. - : Elsevier BV. - 0040-1951 .- 1879-3266. ; 599, s. 8-28
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Journal article (peer-reviewed)abstract
- The Rwenzori Mtns form a striking feature within the Albertine Rift of the East African Rift System. They are made up of a dissected Precambrian metamorphic basement block reaching heights of more than 5 km. Applying low-temperature therrnochronology a complex exhumation history becomes evident, where rock and surface uplift can be traced from Palaeozoic to Neogene times. Fission-track and (U-Th-Sm)/He cooling ages and derived cooling histories allow distinguishing different blocks in the Rwenzori Mtns. In the central part a northern and a southern block are separated by a putative NW-SE trending fault; with the northern block showing distinctly younger apatite fission-track ages (similar to 130 Ma) than the southern block (similar to 300 Ma). Cooling ages in both blocks do not vary significantly with elevation, despite considerable differences in elevation. Thermal history modelling reflects protracted cooling histories. Modelled t-T paths show decoupled blocks that were relocated separately along distinct fault planes, which reactivated pre-existing structures, inherited from Palaeozoic folding and thrusting. Initial cooling affected the Rwenzori area in Silurian to Devonian times, followed by Mesozoic and Cainozoic cooling events. Pre-Neogene evolution seems to be triggered by tectonic processes like the opening of the Indian Ocean and the south Atlantic. From thermochronological data the formation of a Mesozoic Albertine high is conceivable. In Cainozoic times the area was affected by rifting, resulting in differentiated surface uplift. Along the western flank of the Rwenzori Mtns, surface uplift was more pronounced. This is also reflected in their recent topography, formed by accelerated rock uplift in the near past (Pliocene to Pleistocene). Erosion could not compensate for this most recent uplift, resulting in apatite He ages of Oligocene to Miocene age or even older.
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| 6. |
- Claesson, Andreas, et al.
(author)
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Medical versus non medical etiology in out-of-hospital cardiac arrest-Changes in outcome in relation to the revised Utstein template.
- 2016
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In: Resuscitation. - : Elsevier. - 0300-9572 .- 1873-1570. ; 110, s. 48-55
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Journal article (peer-reviewed)abstract
- INTRODUCTION:The Utstein-style recommendations for reporting etiology and outcome in out-of-hospital cardiac arrest (OHCA) from 2004 have recently been revised. Among other etiologies a medical category is now introduced, replacing the cardiac category from Utstein template 2004.AIM:The aim of this study is to describe characteristics and temporal trends from reporting OHCA etiology according to the revised Utstein template 2014 in regards to patient characteristics and 30-day survival rates.METHODS:This registry study is based on consecutive OHCA cases reported from the Emergency medical services (EMS) to the Swedish Registry of Cardiopulmonary Resuscitation (SRCR) 1992-2014. Characteristics, including a presumed cardiac etiology in Utstein template 2004, were transcribed to a medical etiology in Utstein template 2014.RESULTS:Of a total of n=70,846 cases, 92% were categorized as having a medical etiology and 8% as having a non-medical cause. Using the new classifications, the 30-day survival rate has significantly increased over a 20-year period from 4.7% to 11.0% in the medical group and from 3% to 9.9% in the non-medical group (p≤0.001). Trauma was the most common cause in OHCA of a non-medical etiology (26%) with a 30-day survival rate of 3.4% whilst drowning and drug overdose had the highest survival rates (14% and 10% respectively).CONCLUSION:Based on Utstein 2014 categories of etiology, overall survival after OHCA with a medical etiology has more than doubled in a 20-year period and tripled for non-medical cases. Patients with a medical etiology found in a shockable rhythm have the highest chance of survival. There is great variability in characteristics among non-medical cases.
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| 7. |
- Hansman, Reuben J., et al.
(author)
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Structural architecture and Late Cretaceous exhumation history of the Saih Hatat Dome (Oman), a review based on existing data and semi-restorable cross-sections
- 2021
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In: Earth-Science Reviews. - : Elsevier BV. - 0012-8252 .- 1872-6828. ; 217
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Research review (peer-reviewed)abstract
- The Saih Hatat Dome in the Al Hajar Mountains provides an outstanding opportunity to study subduction/exhumation processes coeval with obduction of the Semail Ophiolite. The exceptionally good outcrop conditions offer a unique opportunity to constrain the geometry of this subduction/obduction complex. In this review, the metamorphic, structural, and tectonic evolution of the Oman high-pressure complex in the Saih Hatat Dome is discussed. New structural cross-sections are developed and are used to interpret a geometrically feasible tectonic model for the Saih Hatat Dome. Our review highlights the importance of two major tectonic boundaries: (1) The As Sheik Shear Zone which separates the high pressure rocks of the As Sifah Unit (1.7–2.3 GPa and 510–550 °C) from the overlying Hulw Unit (1.0–1.2 GPa and 250–300 °C), and was active at ~79–76 Ma; and (2) the Upper Plate–Lower Plate Discontinuity, which forms a major surface in the landscape and developed by ~76–74 Ma, cutting through structures of the HP rocks in the lower plate (footwall). This discontinuity is associated with a pronounced strain gradient, notably in its upper plate (hanging wall), and separates rocks that have markedly different deformation geometry. The Upper Plate–Lower Plate Discontinuity initiated with a modest dip angle, making it a neutral structure in terms of crustal shortening vs extension. As a result, there is no discernable break in P-T conditions across it. The upper plate is dominated by the Saih Hatat Fold Nappe, forming between ~76 and 70 Ma. Subsequently, the upper plate has been dissected by a number of NNE-dipping thrusts at ~70–66 Ma, followed by normal faults at <~66 Ma. Our review and tectonic model indicate that the Oman high-pressure rocks were exhumed in a contractional tectonic setting that was possibly driven by forced return flow assisted by buoyancy forces. During this exhumation, when the rocks reached the greenschist-facies middle crust the Upper Plate–Lower Plate Discontinuity formed, as a shallow, south-dipping backthrust. Final exhumation of the high-P rocks was achieved by late normal faults after ~66 Ma.
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| 8. |
- Huth, Cornelia, et al.
(author)
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IL6 gene promoter polymorphisms and type 2 diabetes - Joint analysis of individual participants' data from 21 studies
- 2006
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In: DIABETES. - : American Diabetes Association. - 0012-1797 .- 1939-327X. ; 55:10, s. 2915-2921
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Journal article (peer-reviewed)abstract
- Several lines of evidence indicate a causal role of the cytokine interleukin (IL)-6 in the development of type 2 diabetes in humans. Two common polymorphisms in the promoter of the IL-6 encoding gene IL6, −174G>C (rs1800795) and −573G>C (rs1800796), have been investigated for association with type 2 diabetes in numerous studies but with results that have been largely equivocal. To clarify the relationship between the two IL6 variants and type 2 diabetes, we analyzed individual data on >20,000 participants from 21 published and unpublished studies. Collected data represent eight different countries, making this the largest association analysis for type 2 diabetes reported to date. The GC and CC genotypes of IL6 −174G>C were associated with a decreased risk of type 2 diabetes (odds ratio 0.91, P = 0.037), corresponding to a risk modification of nearly 9%. No evidence for association was found between IL6 −573G>C and type 2 diabetes. The observed association of the IL6 −174 C-allele with a reduced risk of type 2 diabetes provides further evidence for the hypothesis that immune mediators are causally related to type 2 diabetes; however, because the association is borderline significant, additional data are still needed to confirm this finding.
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| 9. |
- Lindahl, Katarina, et al.
(author)
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Allele Dependent Silencing of Collagen Type I Using Small Interfering RNAs Targeting 3'UTR Indels : a Novel Therapeutic Approach in Osteogenesis Imperfecta
- 2013
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In: International Journal of Medical Sciences. - : Ivyspring International Publisher. - 1449-1907. ; 10:10, s. 1333-1343
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Journal article (peer-reviewed)abstract
- Osteogenesis imperfecta, also known as "brittle bone disease", is a heterogeneous disorder of connective tissue generally caused by dominant mutations in the genes COL1A1 and COL1A2, encoding the α1 and α2 chains of type I (pro)collagen. Symptomatic patients are usually prescribed bisphosphonates, but this treatment is neither curative nor sufficient. A promising field is gene silencing through RNA interference. In this study small interfering RNAs (siRNAs) were designed to target each allele of 3'UTR insertion/deletion polymorphisms (indels) in COL1A1 (rs3840870) and COL1A2 (rs3917). For both indels, the frequency of heterozygous individuals was determined to be approximately 50% in Swedish cohorts of healthy controls as well as in patients with osteogenesis imperfecta. Cultures of primary human bone derived cells were transfected with siRNAs through magnet-assisted transfection. cDNA from transfected cells was sequenced in order to measure targeted allele/non-targeted allele ratios and the overall degree of silencing was assessed by quantitative PCR. Successful allele dependent silencing was observed, with promising results for siRNAs complementary to both the insertion and non-insertion harboring alleles. In COL1A1 cDNA the indel allele ratios were shifted from 1 to 0.09 and 0.19 for the insertion and non-insertion allele respectively while the equivalent resulting ratios for COL1A2 were 0.05 and 0.01. Reductions in mRNA abundance were also demonstrated; in cells treated with siRNAs targeting the COL1A1 alleles the average COL1A1 mRNA levels were reduced 65% and 78% compared to negative control levels and in cells treated with COL1A2 siRNAs the average COL1A2 mRNA levels were decreased 26% and 49% of those observed in the corresponding negative controls. In conclusion, allele dependent silencing of collagen type I utilizing 3'UTR indels common in the general population constitutes a promising mutation independent therapeutic approach for osteogenesis imperfecta.
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| 10. |
- Lindahl, Katarina, et al.
(author)
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Decreased fracture rate, pharmacogenetics and BMD response in 79 Swedish children with osteogenesis imperfecta types I, III and IV treated with Pamidronate
- 2016
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In: Bone. - : Elsevier BV. - 8756-3282 .- 1873-2763. ; 87, s. 11-18
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Journal article (peer-reviewed)abstract
- Background: Osteogenesis imperfecta (OI) is an inherited heterogeneous bone fragility disorder, usually caused by collagen I mutations. It is well established that bisphosphonate treatment increases lumbar spine (LS) bone mineral density (BMD), as well as improves vertebral geometry in severe 01; however, fracture reduction has been difficult to prove, pharmacogenetic studies are scarce, and it is not known at which age, or severity of disease, treatment should be initiated.Materials and methods: COL1A1 and COL1A2 were analyzed in 79 children with OI (type I n = 33, type III n = 25 and type IV n = 21) treated with Pamidronate. Data on LS BMD, height, and radiologically confirmed non vertebral and vertebral fractures were collected prior to, and at several time points during treatment.Results: An increase in LS BMD Z-score was observed for all types of OI, and a negative correlation to A LS BMD was observed for both age and LS BMD Z-score at treatment initiation. Supine height Z-scores were not affected by Pamidronate treatment, The fracture rate was reduced for all OI types at all time points during treatment (overall p < 0.0003, < 0.0001 and 0.0003 for all 01 types 1, III and IV respectively). The reduced fracture rate was maintained for types I and IV, while an additional decrease was observed over time for type III. The fracture rate was reduced also in individuals with continued low BMD after >4 yrs Pamidronate. Twice as many boys as girls with 01 type I were treated with Pamidronate, and the fracture rate the year prior treatment was 2.2 times higher for boys (p = 0.0236). Greater Delta LS BMD, but smaller Delta fracture numbers were observed on Pamidronate for helical glycine mutations in COL1A1 vs. COL1A2. Vertebral compression fractures did not progress in any individual during treatment; however, they did not improve in 9%, and these individuals were all >11 years of age at treatment initiation. (p < 0.0001).Conclusion: Pamidronate treatment in children with all types of 01 increased LS BMD, decreased fracture rate, and improved vertebral compression fractures. Fracture reduction was prompt and maintained during treatment, irrespective of age at treatment initiation and collagen I mutation type.
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