| 1. |
- Bousquet, Jean, et al.
(author)
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ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice
- 2021
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In: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 76:1, s. 168-190
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Research review (peer-reviewed)abstract
- Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
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| 2. |
- Bousquet, J. Jean, et al.
(author)
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Next-generation ARIA care pathways for rhinitis and asthma : a model for multimorbid chronic diseases
- 2019
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In: Clinical and Translational Allergy. - : BMC. - 2045-7022. ; 9
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Research review (peer-reviewed)abstract
- Background: In all societies, the burden and cost of allergic and chronic respiratory diseases are increasing rapidly. Most economies are struggling to deliver modern health care effectively. There is a need to support the transformation of the health care system into integrated care with organizational health literacy.Main body: As an example for chronic disease care, MASK (Mobile Airways Sentinel NetworK), a new project of the ARIA (Allergic Rhinitis and its Impact on Asthma) initiative, and POLLAR (Impact of Air POLLution on Asthma and Rhinitis, EIT Health), in collaboration with professional and patient organizations in the field of allergy and airway diseases, are proposing real-life ICPs centred around the patient with rhinitis, and using mHealth to monitor environmental exposure. Three aspects of care pathways are being developed: (i) Patient participation, health literacy and self-care through technology-assisted "patient activation", (ii) Implementation of care pathways by pharmacists and (iii) Next-generation guidelines assessing the recommendations of GRADE guidelines in rhinitis and asthma using real-world evidence (RWE) obtained through mobile technology. The EU and global political agendas are of great importance in supporting the digital transformation of health and care, and MASK has been recognized by DG Sante as a Good Practice in the field of digitally-enabled, integrated, person-centred care.Conclusion: In 20 years, ARIA has considerably evolved from the first multimorbidity guideline in respiratory diseases to the digital transformation of health and care with a strong political involvement.
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| 3. |
- Agapitov, Oleksiy, et al.
(author)
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A statistical study of the propagation characteristics of whistler waves observed by Cluster
- 2011
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In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 38, s. L20103-
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Journal article (peer-reviewed)abstract
- VLF waves play a crucial role in the dynamics of radiation belts, and are responsible for the loss and the acceleration of energetic electrons. Modeling wave-particle interactions requires the best possible knowledge for how wave energy and wave-normal directions are distributed in L-shells and for the magnetic latitudes of different magnetic activity conditions. In this work, we performed a statistical study for VLF emissions using a whistler frequency range for nine years (2001-2009) of Cluster measurements. We utilized data from the STAFF-SA experiment, which spans the frequency range from 8.8 Hz to 3.56 kHz. We show that the wave energy distribution has two maxima around L similar to 4.5 = 6 and L similar to 2, and that wave-normals are directed approximately along the magnetic field in the vicinity of the geomagnetic equator. The distribution changes with magnetic latitude, and so that at latitudes of similar to 30 degrees, wave-normals become nearly perpendicular to the magnetic field. The observed angular distribution is significantly different from Gaussian and the width of the distribution increases with latitude. Since the resonance condition for wave-particle interactions depends on the wave normal orientation, our results indicate that, due to the observed change in the wave-normal direction with latitude, the most efficient particle diffusion due to wave-particle interaction should occur in a limited region surrounding the geomagnetic equator.
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| 4. |
- Agapitov, Oleksiy, et al.
(author)
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Multispacecraft observations of chorus emissions as a tool for the plasma density fluctuations' remote sensing
- 2011
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In: Journal of Geophysical Research. - 0148-0227 .- 2156-2202. ; 116, s. A09222-
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Journal article (peer-reviewed)abstract
- Discrete ELF/VLF chorus emissions are the most intense electromagnetic plasma waves that are observed in the radiation belts and in the outer magnetosphere of the Earth. They are assumed to propagate approximately along the magnetic field lines and are generated in source regions in the vicinity of the magnetic equator and in minimum B pockets in the dayside outer zone of the magnetosphere. The presence of plasma density irregularities along the raypath causes a loss of phase coherence of the chorus wave packets. These irregularities are often present around the plasmapause and in the radiation belts; they occur at scales ranging from a few meters up to several hundred kilometers and can be highly anisotropic. Such irregularities result in fluctuations of the dielectric permittivity, whose statistical properties can be studied making use of intersatellite correlations of whistler waves' phases and amplitudes. We demonstrate how the whistler-mode wave properties can be used to infer statistical characteristics of the density fluctuations. The analogy between weakly coupled oscillators under the action of uncorrelated random forces and wave propagation in a randomly fluctuating medium is used to determine the wave phase dependence on the duration of signal recording time. We study chorus whistler-mode waves observed by the Cluster WBD instrument and apply intersatellite correlation analysis to determine the statistical characteristics of the waveform phases and amplitudes. We then infer the statistical characteristics of the plasma density fluctuations and evaluate the spatial distribution of the irregularities using the same chorus events observed by the four Cluster spacecraft.
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| 5. |
- Agapitov, Oleksiy, et al.
(author)
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Statistics of whistler mode waves in the outer radiation belt : Cluster STAFF-SA measurements
- 2013
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In: Journal of Geophysical Research-Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 118:6, s. 3407-3420
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Journal article (peer-reviewed)abstract
- ELF/VLF waves play a crucial role in the dynamics of the radiation belts and are partly responsible for the main losses and the acceleration of energetic electrons. Modeling wave-particle interactions requires detailed information of wave amplitudes and wave normal distribution over L-shells and over magnetic latitudes for different geomagnetic activity conditions. We performed a statistical study of ELF/VLF emissions using wave measurements in the whistler frequency range for 10years (2001-2010) aboard Cluster spacecraft. We utilized data from the STAFF-SA experiment, which spans the frequency range from 8Hz to 4kHz. We present distributions of wave magnetic and electric field amplitudes and wave normal directions as functions of magnetic latitude, magnetic local time, L-shell, and geomagnetic activity. We show that wave normals are directed approximately along the background magnetic field (with the mean value of the angle between the wave normal and the background magnetic field, about 10 degrees-15 degrees) in the vicinity of the geomagnetic equator. The distribution changes with magnetic latitude: Plasmaspheric hiss normal angles increase with latitude to quasi-perpendicular direction at approximate to 35 degrees-40 degrees where hiss can be reflected; lower band chorus are observed as two wave populations: One population of wave normals tends toward the resonance cone and at latitudes of around 35 degrees-45 degrees wave normals become nearly perpendicular to the magnetic field; the other part remains quasi-parallel at latitudes up to 30 degrees. The observed angular distribution is significantly different from Gaussian, and the width of the distribution increases with latitude. Due to the rapid increase of , the wave mode becomes quasi-electrostatic, and the corresponding electric field increases with latitude and has a maximum near 30 degrees. The magnetic field amplitude of the chorus in the day sector has a minimum at the magnetic equator but increases rapidly with latitude with a local maximum near 12 degrees-15 degrees. The wave magnetic field maximum is observed in the night sector at L>7 during low geomagnetic activity (at L approximate to 5 for K-p>3). Our results confirm the strong dependence of wave amplitude on geomagnetic activity found in earlier studies.
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