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- Boudrie, Gustaf Anton, 1724-1788
(author)
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Dissertatio academica, præcepta Horatii de arte poëtica expositura cujus particulam, consensu ordinis philosophici, in regio athenæo Upsaliensi, publice ventilandam sistunt, præses, Gustav. Ant. Boudrie ... atque respondens, alumnus regius, Olaus Söderlund, Medelpadus. In auditorio Carolino majori, die XXII. Junii, MDCCLXXII. H. a. m. s.
- 1772
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Doctoral thesis (other academic/artistic)
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| 3. |
- Bergh, Jonas, et al.
(author)
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Tailored fluorouracil, epirubicin, and cyclophosphamide compared with marrow-supported high-dose chemotherapy as adjuvant treatment for high-risk breast cancer : A randomised trial
- 2000
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In: The Lancet. - 0140-6736 .- 1474-547X. ; 356:9239, s. 1384-1391
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Journal article (peer-reviewed)abstract
- Background: Chemotherapy drug distribution varies greatly among individual patients. Therefore, we developed an individualised fluorouracil, epirubicin, cyclophosphamide (FEC) regimen to improve outcomes in patients with high-risk early breast cancer. We then did a randomised trial to compare this individually tailored FEC regimen with conventional adjuvant chemotherapy followed by consolidation with high-dose chemotherapy with stem-cell support. Methods: 525 women younger than 60 years of age with high-risk primary breast cancer were randomised after surgery to receive nine cycles of tailored FEC to haematological equitoxicity with granulocyte colony-stimulating factor (G-CSF) support (n=251), or three cycles of FEC at standard doses followed by high-dose chemotherapy with cyclophosphamide, thiotepa, and carboplatin (CTCb), and peripheral-blood stem-cell or bone-marrow support (n=274). Both groups received locoregional radiation therapy and tamoxifen for 5 years. The primary outcome measure was relapse-free survival, and analysis was by intention to treat. Findings: At a median follow-up of 34.3 months, there were 81 breast-cancer relapses in the tailored FEC group versus 113 in the CTCb group (double triangular method p=0.04). 60 deaths occurred in the tailored FEC group and 82 in the CTCb group (log-rank p=0.12). Patients in the CTCb group experienced more grade 3 or 4 acute toxicity compared with the tailored FEC group (p<0.0001). Two treatment-related deaths (0.7%) occurred in the CTCb group. Six patients in the tailored FEC group developed acute myeloid leukaemia and three developed myelodysplastic syndrome. Interpretation: Tailored FEC with G-CSF support resulted in a significantly improved relapse-free survival and fewer grade 3 and 4 toxicities compared with marrow-supported high-dose chemotherapy with CTCb as adjuvant therapy of women with high-risk primary breast cancer.
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| 5. |
- Carlsson, Adrian, et al.
(author)
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KAUDroid : A tool that will spy on applications and how they spy on their users
- 2018
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Reports (other academic/artistic)abstract
- Our mobile phone is today our most precious and condential partof us. In many cases we do not only share phone number with it, butalso our most private information. This information is to some extensionnaively shared and gathered without our knowledge. As the number ofadvanced and sophisticated services increase the more sensitive informa-tion we seem to throw at them. To prevent privacy intrusions Googles'soperation system Android uses something called permissions. Permis-sions are a decision to allow an Android application access to a resourceon a specic device. Once a permission is granted there is no possibil-ity for a user to verify that the application does not take advantage ofthe given trust. With granted permissions applications can collect a vastamount of information without any connection to the service it provides.To highlight this problem we present the KAUDroid platform, a two part,Android application surveillance system. KAUDroid consists of an An-droid application that collect permission usage on phones and a centralserver responsible for data storage. Information is presented to the publicthrough a web user interface using graphs to visualize data in a under-standable manner. With this tool we hope to raise the general awareness ofhow third-party applications tend to abuse their trust and to help peoplerecapture their unconsciously lost privacy.
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| 6. |
- Frygner Holm, Sara, et al.
(author)
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Physical therapists' experiences of learning and delivering a complex behavioral medicine intervention to adolescents with pain
- 2021
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In: Physiotherapy Theory and Practice. - : TAYLOR & FRANCIS INC. - 0959-3985 .- 1532-5040. ; 37:5, s. 583-593
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Journal article (peer-reviewed)abstract
- The objective was to study physical therapists' (PTs') experiences of learning and delivering a complex intervention, a tailored behavioral medicine treatment (BMT) targeting adolescents with pain in primary care. Method: An explorative study with qualitative approach, using content analysis. Three primary care PTs delivering the treatments in a randomized controlled study were interviewed regarding their views on the BMT. Results: The participating PTs considered learning about and delivering the BMT as challenging but rewarding. The biopsychosocial approach, tailoring of the treatment and dialogues with parents were identified as key aspects of the BMT program. The process of formulating a functional behavioral analysis was perceived as strenuous. The supervision of the PTs throughout the study was regarded as crucial and necessary for learning about and providing tailored BMT. Conclusion: Learning about and delivering BMT targeting adolescents with persistent pain is fruitful but laborious and demanding according to three PTs experienced with treatment of pediatric pain in primary care. Extensive education and long periods of supervision seem to be crucial for success and safe delivery according to protocol.
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| 9. |
- Hellmer, Kahl, et al.
(author)
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The eye of the retriever : Developing episodic memory mechanisms in preverbal infants assessed through pupil dilation
- 2018
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In: Developmental Science. - : Wiley. - 1363-755X .- 1467-7687. ; 21:2
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Journal article (peer-reviewed)abstract
- Studying memory in infants can be challenging, as they cannot express their subjective recollection verbally. In this study we use a novel method with which we can assess episodic recognition memory through pupillometry, using identical procedures and stimuli for infants and adults. In three experiments of 4- and 7-month-old infants, and adults we show that the adult pupillary response is larger to previously seen than to never seen items (old/new effect). Pupil dilations index subjective memory experience in adults, producing distinct pupil dilations to items judged as remembered, familiar, and new, regardless of actual previous exposure (Experiment 1). Seven-month-old infants demonstrate a clear pupillary old/new effect, very similar to that of adults (Experiment 2), whereas 4-month-olds do not demonstrate such an effect (Experiment 3). Our findings suggest that the mnemonic mechanisms that serve infants' and adults' episodic recognition memory are more similar than previously asserted: they are not fully developed at 4 months of age but that there is contiguity in human episodic memory development from 7 months of age.
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| 10. |
- Holm, Sara
(author)
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Children and Adolescents with Pain in Primary care : Biopsychosocial determinants and behavioral medicine treatment in a physical therapy framework
- 2014
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Doctoral thesis (other academic/artistic)abstract
- Pain during childhood and adolescents is prevalent and longstanding pain can have severe consequences for children, their families and in the long run for the society. Persisting pain influences many aspects of life and pain-related disability is often associated with impairment, decreased health-related quality of life, school functioning, participation in social life, emotional well-being, and with increased healthcare utilization. The overall aim was to explore, with cross-sectional design, pain conditions, to identify biopsychosocial determinants and their association with pain-related disability, and to study the feasibility of applying a behavioral medicine treatment for adolescents experiencing musculoskeletal pain using randomized controlled design and multimethod approach. Samples of children and adolescents and their parents seeking primary care physical therapy for a pain condition, and a sample of treating physical therapists were included.The results showed that some children had profiles of biopsychosocial determinants that could increase the risk for long-term pain-related disability. Many had long pain duration and multiple pain locations. Girls reported higher levels of catastrophizing compared to boys, who in turn used more behavioral distraction generally regarded as a positive coping strategy.Behavioral medicine treatment, based on a biopsychosocial approach, targeting adolescents with pain was shown to be feasible for use in primary care, with promising outcomes. Tailoring of the treatment was suboptimal but the effect of behavioral medicine treatment in pain-related disability exceeded the effect of the control treatment. The satisfaction with treatment content and results were high for both the control- and experimental condition, significantly higher for the experimental condition as rated by participants. Learning and delivering the behavioral medicine intervention was perceived challenging but rewarding by the treating physical therapists. The biopsychosocial approach in tailoring the treatment, and dialogs with parents were identified as key aspects in the behavioral medicine treatment program.In conclusion, in children seeking primary care for pain, the factors associated with pain-related disability were complex and interrelated. The findings highlight the importance for primary care health care providers to apply a biopsychosocial approach in assessment and treatment, for improvement of activities and participation, and thereby helping children and adolescents regain health.
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