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- Malmberg, Erik, et al.
(author)
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Minimal residual disease assessed with deep sequencing of NPM1 mutations predicts relapse after allogeneic stem cell transplant in AML
- 2019
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In: Leukemia and Lymphoma. - : Informa UK Limited. - 1042-8194 .- 1029-2403. ; 60:2, s. 409-417
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Journal article (peer-reviewed)abstract
- Mutations in NPM1 can be used for minimal residual disease (MRD) analysis in acute myeloid leukemia (AML). We here applied a newly introduced method, deep sequencing, allowing for simultaneous analysis of all recurrent NPM1 insertions and thus constituting an attractive alternative to multiple PCRs for the clinical laboratory. We retrospectively used deep sequencing for measurement of MRD pre- and post-allogeneic hematopoietic stem cell transplantation (alloHCT). For 29 patients in morphological remission at the time of alloHCT, the effect of deep sequencing MRD on outcome was assessed. MRD positivity was defined as variant allele frequency ≥0.02%. Post-transplant MRD status was significantly and independently associated with clinical outcome; 3-year relapse-free survival 20% vs 85% (p <.001), HR 45 (95% CI 2–1260), and overall survival 20% vs 89% (p <.001), HR 49 (95% CI 2–1253). Thus, the new methodology deep sequencing is an applicable and predictive tool for MRD assessment in AML.
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- Samuelsson, Johan Patrik, et al.
(author)
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Thiol-ene coupling reaction of fatty acid monomers
- 2004
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In: Journal of Polymer Science Part A. - : Wiley. - 0887-624X .- 1099-0518. ; 42:24, s. 6346-6352
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Journal article (peer-reviewed)abstract
- The reactivities and reaction rates of the thiol-ene coupling reaction of 2-ethyl-(hydroxymethyl)-1,3-propanediol trimercapto acetate and 2-ethyl-(hydroxymethyl)-1,3-propanediol trimercapto propionate with two common unsaturated fatty acid methyl esters (methyl oleate and methyl linoleate) were evaluated. The reactions were monitored with real-time IR and H-1 NMR, which both showed that the mercapto acetate was more reactive than the mercapto propionate. Both thiols were more prone to add to the monounsaturated methyl oleate than to methyl linoleate, which contained two unconjugated double bonds. According to bond energy calculations, the thiol hydrogen of mercapto acetate was somewhat more difficult to abstract than the hydrogen of mercapto propionate. Consequently, the formed S-C bond in the acetate case was stronger than in the propionate case, and so the equilibrium was more shifted toward the addition products. The real-time IR measurements also showed that the cis unsaturation in methyl oleate isomerized much more quickly than that in methyl linoleate, and this also had an impact on the overall addition rate of the thiols because a trans unsaturation was more reactive than a cis unsaturation. The higher isomerization rates in the oleate systems, compared with those of the linoleate systems, was suggested to be due to a more restricted rotation along the C-C bond of the reacted unsaturation in linoleate. This study showed the importance of trans unsaturations in obtaining reasonable reaction rates in thiol-ene reactions with fatty acid derivatives.
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- Samuelsson, Marcus, 1967-, et al.
(author)
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Undervisning med uppseendeväckande brister : så blev den signifikant bättre
- 2024
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Reports (other academic/artistic)abstract
- Denna rapport är genomförd i samarbete mellan Marcus Samuelsson och Joakim Samuelsson, som forskar om utveckling av skicklig undervisning, samt Bernt Friberg, Urban Hansson och Mats Rosenkvist som är experter på att utveckla evidensbaserad undervisningsskicklighet.Vår rapport bygger på en analys av en serie med 504 lektionsobservationer med fokus på undervisningsskicklighet som genomfördes med alla lärare på 30 grundskolor, 20 F-6 skolor och 10 7–9 skolor. Analysen visar på stor variation i undervisningens genomförande på samtliga skolor och utbredda brister i själva lärprocessen. Under 60 procent av de 504 lektionerna fanns inga lärandemål alls och lärandet synliggjordes sällan under lektionerna. Fokus i klassrummen var på att göra, inte att lära. Under cirka 10 procent av lektionerna hade eleverna förstått vad de skulle lära. Under cirka 45 procent av lektionerna använde läraren ett tydligt och konventionellt ledarskap med fokus på kontroll och sanktioner. Under endast 40 procent av lektionerna var lärarens ledarskap i klassrummet inriktat på att inspirera och motivera för lärande. Eleverna lämnades ofta ensamma att lyckas/misslyckas i arbetet under lektionerna och samlärande med andra elever användes i liten utsträckning. Tränade rutiner lyste med sin frånvaro i de flesta klassrum.Rapporten visar också att alla lärares undervisning blev signifikant bättre med metoden: lektionsobservationer, coachande samtal (”min undervisning”) och kollektiva reflektioner kring data om hur undervisningen genomfördes på skolan (”vår undervisning”). På 14 av de 30 skolorna observerades alla lärare, totalt 188, även en andra gång. Analysen av de observationerna visar att alla lärarnas undervisning då hade blivit signifikant bättre. Det innebär även att lärare som redan var skickliga hade blivit skickligare. Effekten mellan första och andra observationen varierade mellan medelstora och stora effekter för de 10 observerade dimensionerna.En annan sida av resultaten är lärarnas positiva reaktioner. Lärare som får möjlighet att strukturerat reflektera över undervisningsskicklighet i relation till sin undervisning på ett sätt som de känner är meningsfullt vill ha mer. Evidensbaserad undervisningsskicklighet som förmedlades till konkreta iakttagbara handlingar i klassrummet uppskattades eftersom lärarna kunde pröva dessa lärdomar redan nästa lektion.Rapporten visar att det med små resurser går att utveckla det som är framgångsrik evidensbaserad undervisningsskicklighet. Rapporten tydliggör för de som är ansvariga för undervisningen; politiker, rektorsutbildningar, lärarutbildningar, skolchefer, rektorer och lärare, hur brådskande och möjligt det är att utveckla undervisningen. 1,1 miljoner elever är i grundskolan här och nu. Studien kan fungera som inspiration till skolutveckling. Den kan påverka kultur och förhållningssätt inom den egna verksamheten, bidra till professionell dialog om undervisningens kvalitet samt leda till utveckling, mer lärande och högre kunskapsresultat på varje skola.
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4. |
- Ainegren, Mats, 1963-, et al.
(author)
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A Study of Skin-Close Heat and Moisture with Different Types of Backpacks in Cycling
- 2020
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In: The 13th Conference of the International Sports Engineering Association. - Basel Switzerland : MDPI.
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Conference paper (peer-reviewed)abstract
- The aim of this project was to evaluate effects of backpacks with different design intended for use during cycling on skin-close temperature and relative humidity, oxygen uptake, heart rate and aerodynamic drag. Seven subjects took part in the study cycling on a mountain bike mounted on a “smart trainer” placed on a force plate in a wind tunnel. Three series of experiments were carried out: without backpack, with conventional backpack and with a backpack having innovative rear panel design. As hypothesized, the results showed that an innovatively designed backpack with the ducts deflecting part of the airflow towards some areas of the user’s back provided lower temperature and relative humidity for the microclimate compared to a conventional backpack without airflow channels. Further, reference tests without any backpack resulted in the lowest temperature and humidity. However, no differences were found between the three tests for oxygen uptake, heart rate and aerodynamic drag.
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- Andersson, Mats, 1957, et al.
(author)
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A Dolbeault-Grothendieck lemma on complex spaces via Koppelman formulas
- 2012
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In: Inventiones Mathematicae. - : Springer Science and Business Media LLC. - 0020-9910 .- 1432-1297. ; 190:2, s. 261-297
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Journal article (peer-reviewed)abstract
- Let $X$ be a complex space of pure dimension. We introduce fine sheaves $\A^X_q$ of $(0,q)$-currents, which coincides with the sheaves of smooth forms on the regular part of $X$, so that the associated Dolbeault complex yields a resolution of the structure sheaf $\hol^X$. Our construction is based on intrinsic and quite explicit semi-global Koppelman formulas.
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9. |
- Andersson, Mats, 1957, et al.
(author)
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A note on smooth forms on analytic spaces
- 2021
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In: Mathematica Scandinavica. - : Det Kgl. Bibliotek/Royal Danish Library. - 0025-5521 .- 1903-1807. ; 127:3, s. 521-526
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Journal article (peer-reviewed)abstract
- We prove that any smooth mapping between reduced analytic spaces induces a natural pullback operation on smooth differential forms.
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10. |
- Andersson, Mats, 1957, et al.
(author)
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Estimates for the ∂¯ -Equation on Canonical Surfaces
- 2020
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In: Journal of Geometric Analysis. - : Springer Science and Business Media LLC. - 1050-6926 .- 1559-002X. ; 30:3, s. 2974-3001
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Journal article (peer-reviewed)abstract
- We study the solvability in Lp of the ∂¯ -equation in a neighborhood of a canonical singularity on a complex surface, a so-called du Val singularity. We get a quite complete picture in case p= 2 for two natural closed extensions ∂¯ s and ∂¯ w of ∂¯. For ∂¯ s we have solvability, whereas for ∂¯ w there is solvability if and only if a certain boundary condition (∗) is fulfilled at the singularity. Our main tool is certain integral operators for solving ∂¯ introduced by the first and fourth author, and we study mapping properties of these operators at the singularity.
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