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- Arvidsson, Niklas, et al.
(author)
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Industriella anläggningsavtal : Särskilt om ABA 99
- 2024
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Book (other academic/artistic)abstract
- Industriella anläggningsavtal handlar om uppförande eller ombyggnad av anläggningar för produktion av varor, energi eller andra nyttigheter. Anläggningarna kan exempelvis bestå av fabriker eller kraftverk. Avtalen är viktiga för näringsliv, stat och samhälle. Fram till nu har de inte rönt någon större uppmärksamhet i den svenska rättsvetenskapliga litteraturen.Boken ger en bild av vad som utmärker och skiljer industriella anläggningsavtal från andra avtal. Analysen kommenterar särskilt standardkontraktet ABA 99 samt de rättsliga regler och principer som har särskild betydelse för anläggningsavtal. För att sätta in ABA 99 i ett sammanhang görs vissa jämförelser med andra vanligt förekommande standardkontrakt för industriella anläggningar.Boken har huvudsakligen en praktisk inriktning och vänder sig både till jurister, ingenjörer, konsulter och andra som är inblandade på beställar- eller leverantörssidan. Den kan även användas för utbildningsändamål i universitet, högskolor och näringsliv.
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| 2. |
- Bylund, Bengt, et al.
(author)
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Very low birth weight children at 9 years : School performance and behaviour in relation to risk factors
- 2000
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In: Prenatal and Neonatal Medicine. - 1359-8635 .- 1473-0774. ; 5:2, s. 124-133
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Journal article (peer-reviewed)abstract
- Objectives To investigate the school performance and behavior of very low-birth-weight children in comparison with controls, and relate the findings to risk factors. Methods All children with birth weight below 1501 g (VLBW) and normal birth weight (NBW) controls, born in the south-east region of Sweden during a 15-month period in 1987-88, were enrolled in a prospective follow-up study; 81 % (n = 70) and 82% (n = 72), respectively, were re-examined at the age of 9 years regarding growth, neurological status, neurofunctional classification and academic achievement tests (Raven's matrices, mathematics, vocabulary, reading ability). The need for special education at school was assessed and four behavioral problem scores were also assessed (hyperactivity, fine motor skills, gross motor skills, social skills). Children with known handicaps were not re-examined. Results VLBW children were shorter and lighter than controls, and differed from them with regard to neurological functional classification. As a group, they produced poorer results in all academic achievement tests except vocabulary, and also in two out of four behavioral subscales (hyperactivity and fine motor skills). When the comparison was restricted to children with normal Raven scores, almost all the differences disappeared. VLBW children had more reading difficulties but were less often than expected defined as dyslexic compared to NEW children.
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| 6. |
- Tesi, Bianca, et al.
(author)
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Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors : a nationwide, prospective Swedish study
- 2024
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In: The Lancet Regional Health. - : Elsevier. - 2666-7762. ; 39
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Journal article (peer-reviewed)abstract
- BackgroundChildhood cancer predisposition (ChiCaP) syndromes are increasingly recognized as contributing factors to childhood cancer development. Yet, due to variable availability of germline testing, many children with ChiCaP might go undetected today. We report results from the nationwide and prospective ChiCaP study that investigated diagnostic yield and clinical impact of integrating germline whole-genome sequencing (gWGS) with tumor sequencing and systematic phenotyping in children with solid tumors.MethodsgWGS was performed in 309 children at diagnosis of CNS (n = 123, 40%) or extracranial (n = 186, 60%) solid tumors and analyzed for disease-causing variants in 189 known cancer predisposing genes. Tumor sequencing data were available for 74% (227/309) of patients. In addition, a standardized clinical assessment for underlying predisposition was performed in 95% (293/309) of patients.FindingsThe prevalence of ChiCaP diagnoses was 11% (35/309), of which 69% (24/35) were unknown at inclusion (diagnostic yield 8%, 24/298). A second-hit and/or relevant mutational signature was observed in 19/21 (90%) tumors with informative data. ChiCaP diagnoses were more prevalent among patients with retinoblastomas (50%, 6/12) and high-grade astrocytomas (37%, 6/16), and in those with non-cancer related features (23%, 20/88), and ≥2 positive ChiCaP criteria (28%, 22/79). ChiCaP diagnoses were autosomal dominant in 80% (28/35) of patients, yet confirmed de novo in 64% (18/28). The 35 ChiCaP findings resulted in tailored surveillance (86%, 30/35) and treatment recommendations (31%, 11/35).InterpretationOverall, our results demonstrate that systematic phenotyping, combined with genomics-based diagnostics of ChiCaP in children with solid tumors is feasible in large-scale clinical practice and critically guides personalized care in a sizable proportion of patients.
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| 7. |
- Tesi, Bianca, et al.
(author)
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Diagnostic yield and clinical impact of germline sequencing in children with CNS and extracranial solid tumors : a nationwide, prospective Swedish study
- 2024
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In: The Lancet Regional Health. - : Elsevier. - 2666-7762. ; 39
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Journal article (peer-reviewed)abstract
- Background: Childhood cancer predisposition (ChiCaP) syndromes are increasingly recognized as contributing factors to childhood cancer development. Yet, due to variable availability of germline testing, many children with ChiCaP might go undetected today. We report results from the nationwide and prospective ChiCaP study that investigated diagnostic yield and clinical impact of integrating germline whole-genome sequencing (gWGS) with tumor sequencing and systematic phenotyping in children with solid tumors.Methods: gWGS was performed in 309 children at diagnosis of CNS (n = 123, 40%) or extracranial (n = 186, 60%) solid tumors and analyzed for disease-causing variants in 189 known cancer predisposing genes. Tumor sequencing data were available for 74% (227/309) of patients. In addition, a standardized clinical assessment for underlying predisposition was performed in 95% (293/309) of patients.Findings: The prevalence of ChiCaP diagnoses was 11% (35/309), of which 69% (24/35) were unknown at inclusion (diagnostic yield 8%, 24/298). A second-hit and/or relevant mutational signature was observed in 19/21 (90%) tumors with informative data. ChiCaP diagnoses were more prevalent among patients with retinoblastomas (50%, 6/12) and high-grade astrocytomas (37%, 6/16), and in those with non-cancer related features (23%, 20/88), and ≥2 positive ChiCaP criteria (28%, 22/79). ChiCaP diagnoses were autosomal dominant in 80% (28/35) of patients, yet confirmed de novo in 64% (18/28). The 35 ChiCaP findings resulted in tailored surveillance (86%, 30/35) and treatment recommendations (31%, 11/35).Interpretation: Overall, our results demonstrate that systematic phenotyping, combined with genomics-based diagnostics of ChiCaP in children with solid tumors is feasible in large-scale clinical practice and critically guides personalized care in a sizable proportion of patients.Funding: The study was supported by the Swedish Childhood Cancer Fund and the Ministry of Health and Social Affairs.
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| 8. |
- Adestam, Johan, 1982-
(author)
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Den dokumentvillkorade garantin
- 2014
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Doctoral thesis (other academic/artistic)abstract
- Den dokumentvillkorade garantin, som i praktiken vanligen betecknas som självständig, känneteck-nas av att villkoren i utfästelsen väsentligen endast innefattar villkor som refererar till att vissa angivna dokument presenteras för garanten. Dokumentvillkorade garantier förekommer vanligtvis i avtalsstrukturer som involverar ett flertal olika avtal och parter. De typer av avtal som omfattas av sådana avtalsstrukturer ger upphov till speciella rättsliga frågor. Avhandlingen belyser ett antal sådana frågor ur ett svenskt perspektiv, genom att beskriva rättsnormers utformning och tillämpning på olika typer av fall. Särskild vikt läggs vid att upprätthålla ett språkbruk som möjliggör att detta sker på ett motsägelsefritt och rättvisande sätt.En fråga av grundläggande betydelse är hur garantier kan klassificeras på ett sätt som bidrar till att besvara nyss nämnda typ av frågor. En sådan klassifikation, baserad på garantiers innehåll, klargör vad som skiljer den dokumentvillkorade garantin från andra typer av garantier. När det gäller den rättsliga relationen mellan parterna till ett avtal i vilket det föreskrivs att den ena parten, gäldenären, ska låta ombesörja att det ställs ut en garanti till motparten, berörs i synnerhet frågan under vilka omständigheter motparten är fri att begära fullgörelse av garantin och frågan under vilka omständigheter det uppkommer en återkravsrätt för gäldenären gentemot motparten (beneficienten). I fråga om den rättsliga relationen mellan garanten och beneficienten behandlas särskilt frågorna hur man genom tolkning avgör om en garanti är dokumentvillkorad eller inte, hur dokumentvillkoren i en dokumentvillkorad garanti ska tolkas och i vilken mån det finns speciella rättsnormer tillämpliga på dokumentvillkorade garantier. Ytterligare en fråga rör tillämpningen av den tvingande regeln om rättsmissbruk, enligt vilken beneficienten saknar rätt till fullgörelse av garanten om det föreligger rättsmissbruk. Såvitt avser den rättsliga relationen mellan uppdragsgivare och uppdragstagare i uppdrag som relaterar till utfärdandet av en dokumentvillkorad garanti berörs i synnerhet frågan under vilka omständigheter en uppdragstagare har regressrätt gentemot sin uppdragsgivare. En fråga av allmän betydelse är vad som i olika avseenden krävs för att intresset av att uppdragstagare till sådana uppdrag inte ska ha incitament att undersöka svårbedömda omständigheter ska tillgodoses.
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| 10. |
- Al-Zaidi, Zinah, et al.
(author)
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A mobile app as support for pelvic floor muscle training started prior to radical prostatectomy
- 2023
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In: BJUI Compass. - : John Wiley & Sons. - 2688-4526. ; 4:1, s. 114-122
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Journal article (peer-reviewed)abstract
- Objective: To evaluate the usefulness of a mobile app to support pelvic floor muscle training (PFMT) started prior to radical prostatectomy (RP).Materials and methods: A prospective cohort study conducted in Sweden from June 2018 to February 2021 including men for whom RP was planned within 12 months. Users responded anonymously to questionnaires at baseline, 1 and 3 months. Our primary aim was to evaluate if the app could facilitate PFMT and increase confidence in performing pelvic floor muscle (PFM) contractions correctly. Our second aim was to describe the change in urinary incontinence (UI) after RP, based on the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form (ICIQ-UI SF).Results: Of the 3043 users at baseline, 388 met the primary inclusion criteria. Of those, 71 (18.3%) were incontinent, predominantly with slight symptoms. The most common type was urge UI, 39/71 (54.9%). Of the 388 users, 159 (41.0%) answered the questionnaire at 1 month, and 131 (33.7%) at 3 months within 89–135 days. Of those 131, 127 (96.9%) indicated that the app facilitated their training ‘a lot’ or ‘somewhat’. Confidence in performing PFM contractions correctly increased from 39.7% at baseline to 74.0% at 1 month and 87.8% at 3 months (p < 0.001). At baseline, 19.8% performed PFM contractions at least daily, which increased to 74.0% at 1 month and 77.9% at 3 months (p < 0.001). At 3 months, 115/131 (87.8%) had undergone RP, 93.6% of which were robot-assisted. Of the 115, 103 (89.6%) were incontinent, and stress UI dominated. The mean ICIQ-UI SF score increased from 1.2 (2.4 SD) at baseline to 9.6 (5.2 SD), p < 0.001, after surgery.Conclusions: The mobile app facilitated pelvic floor muscle training for men who were planned to undergo radical prostatectomy and used the app.
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