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- Akner, Gunnar, 1953-, et al.
(author)
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Vi står gärna bakom en utfallsbaserad vård
- 2017
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In: Dagens Samhälle. - 1652-6511.
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Journal article (pop. science, debate, etc.)abstract
- Jörgen Nordenström försöker få det till att vår kritik av värdebaserad vård egentligen handlar om att vi vill ha mer resurser. Han har helt missuppfattat oss, skriver 26 specialistläkare i en replik.
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| 4. |
- Alix, James J. P., et al.
(author)
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Assessment of the reliability of the motor unit size index (MUSIX) in single subject "round-robin" and multi-centre settings
- 2019
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In: Clinical Neurophysiology. - : ELSEVIER IRELAND LTD. - 1388-2457 .- 1872-8952. ; 130:5, s. 666-674
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Journal article (peer-reviewed)abstract
- Objective: The motor unit size index (MUSIX) is incorporated into the motor unit number index (MUNIX). Our objective was to assess the intra-/inter-rater reliability of MUSIX in healthy volunteers across single subject "round robin" and multi-centre settings.Methods: Data were obtained from (i) a round-robin assessment in which 12 raters (6 with prior experience and 6 without) assessed six muscles (abductor pollicis brevis, abductor digiti minimi, biceps brachii, tibialis anterior, extensor digitorum brevis and abductor hallucis) and (ii) a multi-centre study with 6 centres studying the same muscles in 66 healthy volunteers. Intrafinter-rater data were provided by 5 centres, 1 centre provided only intra-rater data. Intrafinter-rater variability was assessed using the coefficient of variation (COV), Bland-Altman plots, bias and 95% limits of agreement.Results: In the round-robin assessment intra-rater COVs for MUSIX ranged from 7.8% to 28.4%. Inter-rater variability was between 7.8% and 16.2%. Prior experience did not impact on MUSIX values. In the multi-centre study MUSIX was more consistent than the MUNIX. Abductor hallucis was the least reliable muscle.Conclusions: The MUSIX is a reliable neurophysiological biomarker of reinnervation.Significance: MUSIX could provide insights into the pathophysiology of a range of neuromuscular disorders, providing a quantitative biomarker of reinnervation.
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- Baliakas, Panagiotis, et al.
(author)
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Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study
- 2014
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In: The Lancet Haematology. - 2352-3026. ; 1:2, s. 74-84
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Journal article (peer-reviewed)abstract
- Background About 30% of cases of chronic lymphocytic leukaemia (CLL) carry quasi-identical B-cell receptor immunoglobulins and can be assigned to distinct stereotyped subsets. Although preliminary evidence suggests that B-cell receptor immunoglobulin stereotypy is relevant from a clinical viewpoint, this aspect has never been explored in a systematic manner or in a cohort of adequate size that would enable clinical conclusions to be drawn. Methods For this retrospective, multicentre study, we analysed 8593 patients with CLL for whom immunogenetic data were available. These patients were followed up in 15 academic institutions throughout Europe (in Czech Republic, Denmark, France, Greece, Italy, Netherlands, Sweden, and the UK) and the USA, and data were collected between June 1, 2012, and June 7, 2013. We retrospectively assessed the clinical implications of CLL B-cell receptor immunoglobulin stereotypy, with a particular focus on 14 major stereotyped subsets comprising cases expressing unmutated (U-CLL) or mutated (M-CLL) immunoglobulin heavy chain variable genes. The primary outcome of our analysis was time to first treatment, defined as the time between diagnosis and date of first treatment. Findings 2878 patients were assigned to a stereotyped subset, of which 1122 patients belonged to one of 14 major subsets. Stereotyped subsets showed significant differences in terms of age, sex, disease burden at diagnosis, CD38 expression, and cytogenetic aberrations of prognostic significance. Patients within a specific subset generally followed the same clinical course, whereas patients in different stereotyped subsets-despite having the same immunoglobulin heavy variable gene and displaying similar immunoglobulin mutational status-showed substantially different times to first treatment. By integrating B-cell receptor immunoglobulin stereotypy (for subsets 1, 2, and 4) into the well established Dohner cytogenetic prognostic model, we showed these, which collectively account for around 7% of all cases of CLL and represent both U-CLL and M-CLL, constituted separate clinical entities, ranging from very indolent (subset 4) to aggressive disease (subsets 1 and 2). Interpretation The molecular classification of chronic lymphocytic leukaemia based on B-cell receptor immunoglobulin stereotypy improves the Dohner hierarchical model and refines prognostication beyond immunoglobulin mutational status, with potential implications for clinical decision making, especially within prospective clinical trials.
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| 7. |
- Baliakas, Panagiotis, et al.
(author)
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Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations.
- 2015
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 125:5, s. 856-859
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Journal article (peer-reviewed)abstract
- An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8593 CLL patients of whom 437 (5%) used the IGHV3-21 gene with 254/437 (58%) classified as subset #2. Within subset #2, immunoglobulin heavy variable (IGHV)-mutated cases predominated, whereas non-subset #2/IGHV3-21 was enriched for IGHV-unmutated cases (P = .002). Subset #2 exhibited significantly shorter time-to-first-treatment (TTFT) compared with non-subset #2/IGHV3-21 (22 vs 60 months, P = .001). No such difference was observed between non-subset #2/IGHV3-21 vs the remaining CLL with similar IGHV mutational status. In conclusion, IGHV3-21 CLL should not be axiomatically considered a homogeneous entity with adverse prognosis, given that only subset #2 emerges as uniformly aggressive, contrasting non-subset #2/IGVH3-21 patients whose prognosis depends on IGHV mutational status as the remaining CLL.
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- Bayer, Christian, et al.
(author)
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How accurate is molecular dynamics?
- 2012
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Reports (other academic/artistic)abstract
- Born-Oppenheimer dynamics is shown to provide an accurate approximation of time-independent Schrödinger observables for a molecular system with an electron spectral gap, in the limit of large ratio of nuclei and electron masses, without assuming that the nuclei are localized to vanishing domains. The derivation, based on a Hamiltonian system interpretation of the Schrödinger equation and stability of the corresponding hitting time Hamilton-Jacobi equation for non ergodic dynamics, bypasses the usual separation of nuclei and electron wave functions, includes caustic states and gives a different perspective on theBorn-Oppenheimer approximation, Schrödinger Hamiltonian systems and numerical simulation in molecular dynamics modeling at constant energy.
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- Brackmann, Christian, 1973, et al.
(author)
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Nonlinear microscopy of lipid storage and fibrosis in muscle and liver tissues of mice fed high-fat diets
- 2010
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In: Journal of Biomedical Optics. - : SPIE-Intl Soc Optical Eng. - 1083-3668 .- 1560-2281. ; 15:6
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Journal article (peer-reviewed)abstract
- Hallmarks of high-fat Western diet intake, such as excessive lipid accumulation in skeletal muscle and liver as well as liver fibrosis, are investigated in tissues from mice using nonlinear microscopy, second harmonic generation (SHG), and coherent anti-Stokes Raman scattering (CARS), supported by conventional analysis methods. Two aspects are presented; intake of standard chow versus Western diet, and a comparison between two high-fat Western diets of different polyunsaturated lipid content. CARS microscopy images of intramyocellular lipid droplets in muscle tissue show an increased amount for Western diet compared to standard diet samples. Even stronger diet impact is found for liver samples, where combined CARS and SHG microscopy visualize clear differences in lipid content and collagen fiber development, the latter indicating nonalcoholic fatty liver disease (NAFLD) and steatohepatitis induced at a relatively early stage for Western diet. Characteristic for NAFLD, the fibrous tissue-containing lipids accumulate in larger structures. This is also observed in CARS images of liver samples from two Western-type diets of different polyunsaturated lipid contents. In summary, nonlinear microscopy has strong potential (further promoted by technical advances toward clinical use) for detection and characterization of steatohepatitis already in its early stages.
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| 10. |
- Duval, Florent, et al.
(author)
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The Lyman alpha reference sample VI. Lyman alpha escape from the edge-on disk galaxy Mrk 1486
- 2016
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 587
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Journal article (peer-reviewed)abstract
- Context. Recent numerical simulations suggest that the strength of the Lyman alpha (Ly alpha) line of star-forming disk galaxies strongly depends on the inclination at which they are observed: from edge-on to face-on, we expect to see a change from a strongly attenuated Ly alpha line to a strong Ly alpha emission line.Aims. We aim to understand how a strong Ly alpha emission line is able to escape from the low-redshift highly inclined (edge-on) disk galaxy Mrk 1486 (z similar to 0.0338). To our knowledge, this work is the first observational study of Ly alpha transport inside an edge-on disk galaxy.Methods. Using a large set of HST imaging and spectroscopic data, we investigated the interstellar medium (ISM) structure and the dominant source of Ly alpha radiation inside Mrk 1486. Moreover, using a 3D Monte Carlo Ly alpha radiation transfer code, we studied the radiative transfer of Ly alpha and UV continuum photons inside a 3D geometry of neutral hydrogen (HI) and dust that models the ISM structure at the galaxy center. Our numerical simulations predicted the Ly alpha line profile that we then compared to the one observed in the HST/COS spectrum of Mrk 1486.Results. While a pronounced Ly alpha absorption line emerges from the disk of Mrk 1486, very extended Ly alpha structures are observed at large radii from the galaxy center: a large Ly alpha-halo and two very bright Ly alpha regions located slightly above and below the disk plane. The analysis of IFU H alpha spectroscopic data of Mrk 1486 indicates the presence of two bipolar outflowing halos of HI gas at the same location as these two bright Ly alpha regions. Comparing different diagnostic diagrams (such as [OIII](5007)/H beta versus [OI](6300)/H alpha) to photo-and shock-ionization models, we find that the Ly alpha production of Mrk 1486 is dominated by photoionization inside the galaxy disk. From this perspective, our numerical simulations succeed in reproducing the strength and shape of the observed Ly alpha emission line of Mrk 1486 by assuming a scenario in which the Ly alpha photons are produced inside the galaxy disk, travel along the outflowing halos, and scatter on cool HI materials toward the observer.Conclusions. Extended bipolar galactic winds are frequently observed from star-forming disk galaxies. Given the advantage Ly alpha photons take of such outflowing HI materials to easily escape from Mrk 1486, this mechanism may explain the origin of strong Ly alpha emission lines frequently observed from highly inclined galaxies at high-redshift. This therefore challenges the robustness of the expected viewing-angle effect on the Ly alpha properties of star-forming disk galaxies.
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