↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Sandgren KJ) "

Search: WFRF:(Sandgren KJ)

Result 1-9 of 9

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Bond, E, et al. (author) Plasmacytoid dendritic cells infiltrate the skin in positive tuberculin skin test indurations 2012 In: The Journal of investigative dermatology. - : Elsevier BV. - 1523-1747 .- 0022-202X. ; 132:1, s. 114-123 Journal article (peer-reviewed)
2.	Bond, E, et al. (author) Techniques for time-efficient isolation of human skin dendritic cell subsets and assessment of their antigen uptake capacity 2009 In: Journal of immunological methods. - : Elsevier BV. - 1872-7905 .- 0022-1759. ; 348:1-2, s. 42-56 Journal article (peer-reviewed)
3.	Liang, F, et al. (author) Dendritic cell recruitment in response to skin antigen tests in HIV-1-infected individuals correlates with the level of T-cell infiltration 2013 In: AIDS (London, England). - 1473-5571. ; 27:7, s. 1071-1080 Journal article (peer-reviewed)
4.	Liang, F, et al. (author) Infiltration of dendritic cells and antigen uptake in the muscle after injection of HIV-1 Env gp120 in adjuvant 2012 In: RETROVIROLOGY. ; 9 Conference paper (other academic/artistic)
5.	Liang, F, et al. (author) Vaccine Adjuvants Induce Distinct Innate Immune Activation Profiles In Vivo 2013 In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - 0889-2229. ; 29:11, s. A94-A94 Conference paper (other academic/artistic)
6.	Liang, F, et al. (author) Vaccine priming is restricted to draining lymph nodes and controlled by adjuvant-mediated antigen uptake 2017 In: Science translational medicine. - : American Association for the Advancement of Science (AAAS). - 1946-6242 .- 1946-6234. ; 9:393 Journal article (peer-reviewed)abstract Vaccine responses are initiated in vaccine-draining lymph nodes and depend on the efficiency by which adjuvants influence antigen uptake.
7.	Salvador, A, et al. (author) Design and evaluation of surface and adjuvant modified PLGA microspheres for uptake by dendritic cells to improve vaccine responses 2015 In: International journal of pharmaceutics. - : Elsevier BV. - 1873-3476 .- 0378-5173. ; 496:2, s. 371-381 Journal article (peer-reviewed)
8.	Sandgren, KJ, et al. (author) A differential role for macropinocytosis in mediating entry of the two forms of vaccinia virus into dendritic cells 2010 In: PLoS pathogens. - : Public Library of Science (PLoS). - 1553-7374. ; 6:4, s. e1000866- Journal article (peer-reviewed)
9.	Sandgren, KJ, et al. (author) Human plasmacytoid dendritic cells efficiently capture HIV-1 envelope glycoproteins via CD4 for antigen presentation 2013 In: Journal of immunology (Baltimore, Md. : 1950). - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 191:1, s. 60-69 Journal article (peer-reviewed)abstract Advances in HIV-1 vaccine clinical trials and preclinical research indicate that the virus envelope glycoproteins (Env) are likely to be an essential component of a prophylactic vaccine. Efficient Ag uptake and presentation by dendritic cells (DCs) is important for strong CD4+ Th cell responses and the development of effective humoral immune responses. In this study, we examined the capacity of distinct primary human DC subsets to internalize and present recombinant Env to CD4+ T cells. Consistent with their specific receptor expression, skin DCs bound and internalized Env via C-type lectin receptors, whereas blood DC subsets, including CD1c+ myeloid DCs, CD123+ plasmacytoid DCs (PDCs), and CD141+ DCs exhibited a restricted repertoire of C-type lectin receptors and relied on CD4 for uptake of Env. Despite a generally poor capacity for Ag uptake compared with myeloid DCs, the high expression of CD4 on PDCs allowed them to bind and internalize Env very efficiently. CD4-mediated uptake delivered Env to EEA1+ endosomes that progressed to Lamp1+ and MHC class II+ lysosomes where internalized Env was degraded rapidly. Finally, all three blood DC subsets were able to internalize an Env-CMV pp65 fusion protein via CD4 and stimulate pp65-specific CD4+ T cells. Thus, in the in vitro systems described in this paper, CD4-mediated uptake of Env is a functional pathway leading to Ag presentation, and this may therefore be a mechanism used by blood DCs, including PDCs, for generating immune responses to Env-based vaccines.

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-9 of 9

Refine your search

Type of publication: journal article (7); conference paper (2)

Type of content: peer-reviewed (7); other academic/artistic (2)

Author/Editor: Sandgren, KJ (9); Lore, K (7); Liang, F (6); Koup, RA (5); Andersson, J (3); Bond, E (3); show more...; Smed-Sorensen, A (3); Seder, RA (3); Seubert, A. (3); Thompson, EA (3); De Gregorio, E. (3); Lange, C. (2); Rao, S (2); Adams, WC (2); Lindgren, G (2); Rangaka, MX (2); Wilkinson, RJ (2); Fausther-Bovendo, H (2); Sullivan, NJ (2); O'hagan, D (2); Hofmann, A (1); aut (1); Bergman, P. (1); Wilkinson, J. (1); Lederman, MM (1); Cunningham, AL (1); Brighenti, S (1); Perbeck, L (1); Betemariam, SA (1); McInerney, GM (1); Robinson, PJ (1); Barnett, S (1); McComsey, GA (1); Sullivan, N (1); Francica, JR (1); O'Hagan, DT (1); Pedraz, JL (1); Hernandez, RM (1); Igartua, M (1); Salvador, A (1); Miranda-Saksena, M (1); Byth-Wilson, K (1); show less...

University: Karolinska Institutet (9)

Language: English (9)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view