| 1. |
- Alsterholm, Mikael, 1977, et al.
(författare)
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Establishment and utility of SwedAD : a nationwide Swedish registry for patients with atopic dermatitis receiving systemic pharmacotherapy
- 2023
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Ingår i: Acta Dermato-Venereologica. - : Medical Journals Sweden AB. - 0001-5555 .- 1651-2057. ; 103
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Tidskriftsartikel (refereegranskat)abstract
- SwedAD, a Swedish nationwide registry for patients with atopic dermatitis receiving systemic pharmacotherapy, was launched on 1 September 2019. We describe here the establishment of a user-friendly registry to the benefit of patients with atopic dermatitis. By 5 November 2022, 38 clinics had recorded 931 treatment episodes in 850 patients with an approximate national coverage rate of 40%. Characteristics at enrolment included median Eczema Area and Severity Index (EASI) 10.2 (interquartile range 4.0, 19.4), Patient-Oriented Eczema Measure (POEM) 18.0 (10.0, 24.0), Dermatology Life Quality Index (DLQI) 11.0 (5.0, 19.0) and Peak Itch Numerical Rating Scale-11 (NRS-11) 6.0 (3.0, 8.0). At 3 months, median EASI was 3.2 (1.0, 7.3) and POEM, DLQI, and NRS-11 were improved. Regional coverage varied, reflecting the distribution of dermatologists, the ratio of public to private healthcare, and difficulties in recruiting certain clinics. This study highlights the importance of a nationwide registry when managing systemic pharmacotherapy of atopic dermatitis.
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| 2. |
- Sigurdardottir, Gunnthorunn, et al.
(författare)
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Cross-Cultural Validation of the RECAP of Atopic Eczema Question-naire in a Swedish Population
- 2024
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Ingår i: Acta dermato-venereologica. - : Medical Journals Sweden. - 1651-2057 .- 0001-5555. ; 104
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Tidskriftsartikel (refereegranskat)abstract
- A Swedish translation of the patient-reported outcome measure for assessing long-term control of atopic dermatitis, Recap of atopic eczema (RECAP), has not been validated. Cross-cultural translation and multi-centre validation of the translated RECAP questionnaire were therefore performed. Disease severity was assessed using the validated Investigator Global Assessment Scale for atopic dermatitis (vIGA-ADTM). The Swedish RECAP was completed by 208 individuals aged 16 years or older with a median age of 36 years (interquartile range [IQR] 27-48). The participants considered the questionnaire suitable for assessing eczema control. The median RECAP score (range 0-28) was 12 (IQR 5-19). The mean and median vIGA-ADTM scores (range 0-4) were 2 (standard deviation [SD] 2) and 3 (IQR 2-4), respectively. A correlation between RECAP and the vIGA-ADTM was observed (p<0.001). There was no significant change in scores for participants who answered the questionnaire twice within 14 days. Over time, improved or worsened eczema, as evaluat-ed by vIGA-ADTM, affected RECAP scores significantly (p<0.001). The study suggests that RECAP can assess AD control in a Swedish clinical setting and shows -acceptable reliability.
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| 3. |
- Akaberi, Dario, et al.
(författare)
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Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease
- 2020
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Ingår i: Journal of Biomolecular Structure and Dynamics. - : Informa UK Limited. - 0739-1102 .- 1538-0254. ; 38:18, s. 5526-5536
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Tidskriftsartikel (refereegranskat)abstract
- Zika virus (ZIKV) is an emerging mosquito-borne flavivirus and infection by ZIKV Asian lineage is known to cause fetal brain anomalies and Guillain-Barrés syndrome. The WHO declared ZIKV a global public health emergency in 2016. However, currently neither vaccines nor antiviral prophylaxis/treatments are available. In this study, we report the identification of a C2-symmetric diol-based Human immunodeficiency virus type-1 (HIV) protease inhibitor active against ZIKV NS2B-NS3 protease. The compound, referred to as 9b, was identified by in silico screening of a library of 6265 protease inhibitors. Molecular dynamics (MD) simulation studies revealed that compound 9b formed a stable complex with ZIKV protease. Interaction analysis of compound 9b's binding pose from the cluster analysis of MD simulations trajectories predicted that 9b mostly interacted with ZIKV NS3. Although designed as an aspartyl protease inhibitor, compound 9b was found to inhibit ZIKV serine protease in vitro with IC50 = 143.25 ± 5.45 µM, in line with the in silico results. Additionally, linear interaction energy method (LIE) was used to estimate binding affinities of compounds 9b and 86 (a known panflavivirus peptide hybrid with IC50 = 1.64 ± 0.015 µM against ZIKV protease). The LIE method correctly predicted the binding affinity of compound 86 to be lower than that of 9b, proving to be superior to the molecular docking methods in scoring and ranking compounds. Since most of the reported ZIKV protease inhibitors are positively charged peptide-hybrids, with our without electrophilic warheads, compound 9b represents a less polar and more drug-like non-peptide hit compound useful for further optimization.Communicated by Ramaswamy Sarma.
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| 4. |
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| 5. |
- Akaberi, Dario, et al.
(författare)
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Targeting the NS2B-NS3 protease of tick-borne encephalitis virus with pan-flaviviral protease inhibitors
- 2021
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Ingår i: Antiviral Research. - : Elsevier. - 0166-3542 .- 1872-9096. ; 190
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Tidskriftsartikel (refereegranskat)abstract
- Tick-borne encephalitis (TBE) is a severe neurological disorder caused by tick-borne encephalitis virus (TBEV), a member of the Flavivirus genus. Currently, two vaccines are available in Europe against TBEV. However, TBE cases have been rising in Sweden for the past twenty years, and thousands of cases are reported in Europe, emphasizing the need for antiviral treatments against this virus. The NS2B-NS3 protease is essential for flaviviral life cycle and has been studied as a target for the design of inhibitors against several well-known flaviviruses, but not TBEV. In the present study, Compound 86, a known tripeptidic inhibitor of dengue (DENV), West Nile (WNV) and Zika (ZIKV) proteases, was predicted to be active against TBEV protease using a combination of in silico techniques. Further, Compound 86 was found to inhibit recombinant TBEV protease with an IC50 = 0.92 mu M in the in vitro enzymatic assay. Additionally, two more peptidic analogues were synthetized and they displayed inhibitory activities against both TBEV and ZIKV proteases. In particular, Compound 104 inhibited ZIKV protease with an IC50 = 0.25 mu M. These compounds represent the first reported inhibitors of TBEV protease to date and provides valuable information for the further development of TBEV as well as pan-flavivirus protease inhibitors.
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| 6. |
- Alakangas, Lena, et al.
(författare)
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Project: Improve Resource Efficiency and Minimize Environmental Footprint
- 2016
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Annan publikation (populärvet., debatt m.m.)abstract
- The REMinE project is organized in five work packages that comprise: detailedcharacterization and risk assessment of the mine wastes selected (WP2), identification of new processing methods for mine waste (WP3), characterization and risk assessment of the remaining residuals (WP4), outlining business opportunities and environmental impact in a conceptual model for sustainable mining (WP5). The project comprises case studies of historical mine wastes from three different European countries, namely Portugal, Romania and Sweden. The interdisciplinary research collaboration in this project is innovative in the sense that separation of minerals and extraction of metals not only are basedon technical and economic gain but also considers the environmental perspective.
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| 7. |
- Awe, Samuel Ayowole, et al.
(författare)
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Dissolution kinetics of tetrahedrite mineral in alkaline sulphide media
- 2010
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Ingår i: Hydrometallurgy. - : Elsevier BV. - 0304-386X .- 1879-1158. ; 103:1-4, s. 167-172
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Tidskriftsartikel (refereegranskat)abstract
- The present study investigates the dissolution kinetics of tetrahedrite in aqueous alkaline sodium sulphide solutions. Effect of reaction temperature, mineral particle size, sodium sulphide and sodium hydroxide concentrations on antimony and arsenic dissolution rate from tetrahedrite were studied. It was found that the rate of reaction increases with increase in reaction temperature, sodium sulphide concentration, and sodium hydroxide concentration and with decrease in mineral particle size. The kinetic study indicates that the rate of tetrahedrite leaching in the lixiviant under selected conditions is chemically controlled through the particle surface reaction. The estimated activation energies were found to be 81 kJ/mol and 75 kJ/mol, respectively, for antimony and arsenic dissolution from tetrahedrite, which are in agreement with the values of activation energies reported for the chemically controlled reaction process
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| 8. |
- Awe, Samuel Ayowole, et al.
(författare)
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Electrowinning of antimony from model sulphide alkaline solutions
- 2013
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Ingår i: Hydrometallurgy. - : Elsevier BV. - 0304-386X .- 1879-1158. ; 137, s. 60-67
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Tidskriftsartikel (refereegranskat)abstract
- The influence of initial antimony concentration, cathode current density, the concentrations of Na2S and NaOH, gas sparging and electrolyte temperature on average cell voltage, specific energy and current efficiency of antimony deposition has been studied. The experiments were conducted in a nondiaphragm electrolytic cell. Results revealed that increase in initial antimony concentration, temperature of the electrolyte and NaOH concentration enhanced the current efficiency. Excessive sodium sulphide concentration in the electrolyte promotes the formation of unwanted polysulphide and thiosulphate ions which can significantly decrease the current efficiency of the process. Sparging of the electrolyte facilitates a smooth and adherent antimony deposit with an improved purity. About 99.6% antimony purity was achieved when the electrolyte was sparged at 10 mL/min. The result showed that increase in NaOH concentration considerably promotes the formation of sulphate ions as the main anodic product. Anodic current efficiencies of 98% and 99% based on the amount of sulphate formed were obtained at sodium hydroxide concentrations of 8.75 M and 10 M, respectively. Average cell potential increased with increasing NaOH concentration and cathode current density. The preferred crystallographic orientations of the antimony deposit obtained at 2.5 M NaOH concentration are in the orders (012) (202) (110) (104), but the order becomes (012) (110) (104) (202) when NaOH concentration is increased further. The order of crystal orientations for antimony electrodeposition at 50 A/m2 cathodic current density is (012) (110) (104) (202), which does not change with increasing cathode current density but the peaks at (110) (104) (202) crystal planes become more broadened and suppressed as current density increased.
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| 9. |
- Awe, Samuel Ayowole, et al.
(författare)
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Elimination and recovery of antimony from copper resources
- 2013
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Konferensbidrag (refereegranskat)abstract
- In a response to the recent growth in the global demand for copper products, mining industries have intensified in their mining operations. Unfortunately, the grade of copper ore concentrates mined today is declining due to the intensive mining of the relatively high grade copper resources. Therefore, future copper ore deposits to be mined are likely to be richer in impurity elements like antimony and arsenic which attract smelter’s penalty if the content of these impurities is too high. It is however imperative to selectively eliminate and recover the antimony impurity of the copper concentrates in an environmentally friendly process with a view of upgrading the concentrates for a pyrometallurgical processing.This paper discusses the alkaline sulphide hydrometallurgical technology to selectively solubilize antimony impurity from a copper concentrate. The effect of sodium sulphide and sodium hydroxide concentrations, leaching time and leaching temperature on antimony dissolution will be examined. Furthermore, antimony recovery as a marketable product from simulated pregnant leach liquor through electrodeposition will be discussed. Various experimental factors that influence antimony deposition from alkaline sulphide electrolyte are reported.
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| 10. |
- Awe, Samuel Ayowole, et al.
(författare)
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Formation of sulphur oxyanions and their influence on antimony electrowinning from sulphide electrolytes
- 2013
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Ingår i: Minerals Engineering. - : Elsevier BV. - 0892-6875 .- 1872-9444. ; 53, s. 39-47
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Tidskriftsartikel (refereegranskat)abstract
- Antimony electrowinning from synthetic alkaline sulphide electrolytes has been studied in a nondiaphragm electrolytic cell. The electrodes were constructed in such a way that the anode produces ten times higher current density than the cathodic current density to promote sulphide oxidation to sulphate at the anode; and simultaneously decreasing the tendency of hydrogen evolution at the cathode. The result revealed that at an anodic current density lower than 1500 A/m2, minute amounts of sulphate ions were formed but when the anode current density increased beyond 1500 A/m2, sulphate formation was promoted. The initial molar concentration ratio between hydroxide and free sulphide ions should be ≥ 10.3 to avoid thiosulphate formation at 2000 A/m2 anodic current density under the conditions used in these experiments. The highest anodic current efficiency obtained based on the amount of sulphate formed was 89%. An increase in the anode current density as well as NaOH concentration enhances the cathodic and anodic current efficiencies with respect to the antimony metal deposited and sulphate ions produced, respectively. Despite the high anodic current densities used, the specific energy of this process ranges from 0.6 to 2.3 kWh/kg which is significantly lower than values reported previously due to the prevention of undesirable sulphur species from being formed. The tests revealed that the concentration of thiosulphate formed during the electrolysis decreased with increasing anode current density and NaOH concentration. Addition of polysulphide from 0 to 30 g/L to the electrolyte decreases the current efficiency from 83% to 32% and correspondingly increases the specific energy from 1.7 to 4.8 kWh/kg. Results showed that a build-up of sulphite and sulphate ions in the solution does not have any detrimental effect on the current efficiency of antimony deposition.
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