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- Birnbaum, Bernard A., et al.
(author)
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Hepatic hemangiomas: diagnosis with fusion of MR, CT, and Tc-99m-labeled red blood cell SPECT images
- 1991
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In: Radiology. - : Radiological Society of North America. - 0033-8419 .- 1527-1315. ; 181:2, s. 469-474
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Journal article (peer-reviewed)abstract
- A method of image analysis was developed for correlation of hemangiomas detected at computed tomography {(CT)} and/or magnetic resonance {(MR)} imaging with increased blood pool activity evident at single photon emission {CT} {(SPECT)} performed after labeling of red blood cells with technetium-99m. Image analysis was performed in 20 patients with 35 known hepatic hemangiomas. After section thickness and pixel sizes of the different studies were matched, intrinsic landmarks were chosen to identify anatomically corresponding locations. Regions of interest {(ROIs)} drawn on the {CT} and/or {MR} images were translated, rotated, and reprojected to match the areas of interest on the corresponding {SPECT} images by means of a two-dimensional polynomial-based warping algorithm. Analysis of {ROIs} on 30 {SPECT-MR} and 20 {SPECT-CT} pairs of registered images provided absolute confirmation that 34 suspected hemangiomas identified on {SPECT} images correlated exactly with lesions seen on {CT} and/or {MR} images. Accuracy of fusion was within an average of 1.5 pixels +/- 0.8 (+/- 1 standard deviation). The technique enabled diagnostic confirmation of hemangiomas as small as 1.0 cm and proved useful for evaluating lesions located adjacent to intrahepatic vessels.
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- Kramer, Elissa L., et al.
(author)
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CT-SPECT fusion to correlate radiolabeled monoclonal antibody uptake with abdominal CT findings
- 1989
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In: Radiology. - : American College of Radiology. - 0033-8419 .- 1527-1315. ; 172:3, s. 861-865
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Journal article (peer-reviewed)abstract
- To enhance the information provided by computed tomography {(CT)} and single photon emission computed tomography {(SPECT)} performed with radiolabeled, anti-carcinoembryonic antigen monoclonal antibody {(MoAb)}, the authors performed fusion of these types of images from eight subjects with suspected colorectal adenocarcinoma. Section thickness and pixel size of the two studies were matched, coordinates of corresponding points from each study were identified, and {CT} sections were translated, rotated, and reprojected to match the corresponding {SPECT} scans. The {CT-SPECT} fusion enabled identification of anatomic sites of tumor-specific {MoAb} accumulation in four cases, showed non-specific {MoAb} accumulation in two, and helped confirm information only suggested by the two studies separately in one.
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