| 1. |
- Bernardi, Anna, et al.
(author)
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Multivalent glycoconjugates as anti-pathogenic agents
- 2013
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In: Chemical Society Reviews. - : Royal Society of Chemistry (RSC). - 0306-0012 .- 1460-4744. ; 42:11, s. 4709-4727
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Research review (peer-reviewed)abstract
- Multivalency plays a major role in biological processes and particularly in the relationship between pathogenic microorganisms and their host that involves protein-glycan recognition. These interactions occur during the first steps of infection, for specific recognition between host and bacteria, but also at different stages of the immune response. The search for high-affinity ligands for studying such interactions involves the combination of carbohydrate head groups with different scaffolds and linkers generating multivalent glycocompounds with controlled spatial and topology parameters. By interfering with pathogen adhesion, such glycocompounds including glycopolymers, glycoclusters, glycodendrimers and glyconanoparticles have the potential to improve or replace antibiotic treatments that are now subverted by resistance. Multivalent glycoconjugates have also been used for stimulating the innate and adaptive immune systems, for example with carbohydrate-based vaccines. Bacteria present on their surfaces natural multivalent glycoconjugates such as lipopolysaccharides and S-layers that can also be exploited or targeted in anti-infectious strategies.
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| 2. |
- De Donato, Lorenzo, et al.
(author)
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Intelligent detection of warning bells at level crossings through deep transfer learning for smarter railway maintenance
- 2023
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In: Engineering applications of artificial intelligence. - : Elsevier Ltd. - 0952-1976 .- 1873-6769. ; 123
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Journal article (peer-reviewed)abstract
- Level Crossings are among the most critical railway assets, concerning both the risk of accidents and their maintainability, due to intersections with promiscuous traffic and difficulties in remotely monitoring their health status. Failures can be originated from several factors, including malfunctions in the bar mechanisms and warning devices, such as light signals and bells. This paper focuses on the intelligent detection of anomalies in warning bells through non-intrusive acoustic monitoring by: (1) introducing a new concept for autonomous monitoring of level crossings; (2) generating and sharing a specific dataset collecting relevant audio signals from publicly available audio recordings; (3) implementing and evaluating a solution combining deep learning and transfer learning for warning bell detection. The results show a high accuracy in detecting anomalies and suggest viability of the approach in real-world applications, especially where network cameras with on-board microphones are installed for multi-purpose level crossing surveillance.
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| 3. |
- Donato, Lorenzo De, et al.
(author)
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A Survey on Audio-Video Based Defect Detection Through Deep Learning in Railway Maintenance
- 2022
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In: IEEE Access. - : IEEE. - 2169-3536. ; 10, s. 65376-65400
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Journal article (peer-reviewed)abstract
- Within Artificial Intelligence, Deep Learning (DL) represents a paradigm that has been showing unprecedented performance in image and audio processing by supporting or even replacing humans in defect and anomaly detection. The railway sector is expected to benefit from DL applications, especially in predictive maintenance applications, where smart audio and video sensors can be leveraged yet kept distinct from safety-critical functions. Such separation is crucial, as it allows for improving system dependability with no impact on its safety certification. This is further supported by the development of DL in other transportation domains, such as automotive and avionics, opening for knowledge transfer opportunities and highlighting the potential of such a paradigm in railways. In order to summarize the recent state-of-the-art while inquiring about future opportunities, this paper reviews DL approaches for the analysis of data generated by acoustic and visual sensors in railway maintenance applications that have been published until August 31st, 2021. In this paper, the current state of the research is investigated and evaluated using a structured and systematic method, in order to highlight promising approaches and successful applications, as well as to identify available datasets, current limitations, open issues, challenges, and recommendations about future research directions.
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