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Search: WFRF:(Sasov A)

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1.
  • Velroyen, A, et al. (author)
  • Grating-based X-ray Dark-field Computed Tomography of Living Mice.
  • 2015
  • In: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 2:10, s. 1500-1506
  • Journal article (peer-reviewed)abstract
    • Changes in x-ray attenuating tissue caused by lung disorders like emphysema or fibrosis are subtle and thus only resolved by high-resolution computed tomography (CT). The structural reorganization, however, is of strong influence for lung function. Dark-field CT (DFCT), based on small-angle scattering of x-rays, reveals such structural changes even at resolutions coarser than the pulmonary network and thus provides access to their anatomical distribution. In this proof-of-concept study we present x-ray in vivo DFCTs of lungs of a healthy, an emphysematous and a fibrotic mouse. The tomographies show excellent depiction of the distribution of structural - and thus indirectly functional - changes in lung parenchyma, on single-modality slices in dark field as well as on multimodal fusion images. Therefore, we anticipate numerous applications of DFCT in diagnostic lung imaging. We introduce a scatter-based Hounsfield Unit (sHU) scale to facilitate comparability of scans. In this newly defined sHU scale, the pathophysiological changes by emphysema and fibrosis cause a shift towards lower numbers, compared to healthy lung tissue.
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2.
  • Bech, Martin, et al. (author)
  • In-vivo dark-field and phase-contrast x-ray imaging.
  • 2013
  • In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 3:Nov 13
  • Journal article (peer-reviewed)abstract
    • Novel radiography approaches based on the wave nature of x-rays when propagating through matter have a great potential for improved future x-ray diagnostics in the clinics. Here, we present a significant milestone in this imaging method: in-vivo multi-contrast x-ray imaging of a mouse using a compact scanner. Of particular interest is the enhanced contrast in regions related to the respiratory system, indicating a possible application in diagnosis of lung diseases (e.g. emphysema).
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