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1.	Kanoni, Stavroula, et al. (author) Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. 2022 In: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1 Journal article (peer-reviewed)abstract Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
2.	Breznau, Nate, et al. (author) Observing many researchers using the same data and hypothesis reveals a hidden universe of uncertainty 2022 In: Proceedings of the National Academy of Sciences of the United States of America. - : National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 119:44 Journal article (peer-reviewed)abstract This study explores how researchers analytical choices affect the reliability of scientific findings. Most discussions of reliability problems in science focus on systematic biases. We broaden the lens to emphasize the idiosyncrasy of conscious and unconscious decisions that researchers make during data analysis. We coordinated 161 researchers in 73 research teams and observed their research decisions as they used the same data to independently test the same prominent social science hypothesis: that greater immigration reduces support for social policies among the public. In this typical case of social science research, research teams reported both widely diverging numerical findings and substantive conclusions despite identical start conditions. Researchers expertise, prior beliefs, and expectations barely predict the wide variation in research outcomes. More than 95% of the total variance in numerical results remains unexplained even after qualitative coding of all identifiable decisions in each teams workflow. This reveals a universe of uncertainty that remains hidden when considering a single study in isolation. The idiosyncratic nature of how researchers results and conclusions varied is a previously underappreciated explanation for why many scientific hypotheses remain contested. These results call for greater epistemic humility and clarity in reporting scientific findings.
3.	Aad, G, et al. (author) ATLAS Run 1 searches for direct pair production of third-generation squarks at the Large Hadron Collider. 2015 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:10 Journal article (peer-reviewed)
4.	Aad, G, et al. (author) Constraints on the off-shell Higgs boson signal strength in the high-mass ZZ and WW final states with the ATLAS detector. 2015 In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 75:7 Journal article (peer-reviewed)
5.	Aad, G, et al. (author) Evidence for Electroweak Production of W^{±}W^{±}jj in pp Collisions at sqrt[s]=8 TeV with the ATLAS Detector. 2014 In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 113:14 Journal article (peer-reviewed)
6.	Aad, G, et al. (author) Measurement of Spin Correlation in Top-Antitop Quark Events and Search for Top Squark Pair Production in pp Collisions at sqrt[s]=8 TeV Using the ATLAS Detector. 2015 In: Physical Review Letters. - : Elsevier. - 1079-7114 .- 0031-9007. ; 114:14 Journal article (peer-reviewed)
7.	Aad, G, et al. (author) Measurement of the top-quark mass in the fully hadronic decay channel from ATLAS data at [Formula: see text]. 2015 In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 75:4 Journal article (peer-reviewed)
8.	Aad, G, et al. (author) Measurements of the Nuclear Modification Factor for Jets in Pb+Pb Collisions at sqrt[s_{NN}]=2.76 TeV with the ATLAS Detector. 2015 In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 114:7 Journal article (peer-reviewed)
9.	Aad, G, et al. (author) Observation of an Excited B_{c}^{±} Meson State with the ATLAS Detector. 2014 In: Physical Review Letters. - : American Physical Society. - 1079-7114 .- 0031-9007. ; 113:21 Journal article (peer-reviewed)
10.	Aad, G, et al. (author) Performance of the ATLAS muon trigger in pp collisions at [Formula: see text] TeV. 2015 In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 75:3 Journal article (peer-reviewed)

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Type of publication: journal article (383); conference paper (19); other publication (11); doctoral thesis (10); research review (7); reports (4); show more...; licentiate thesis (3); show less...

Type of content: peer-reviewed (396); other academic/artistic (37); pop. science, debate, etc. (4)

Author/Editor: Chen, L (142); Alonso, A. (142); Aad, G (141); Abbott, B. (141); Abdinov, O (141); Zwalinski, L. (141); show more...; Gregersen, K. (141); Poettgen, R. (141); Aben, R. (141); Abreu, H. (141); Adye, T. (141); Ahmadov, F. (141); Aielli, G. (141); Albrand, S. (141); Aleksa, M. (141); Aleksandrov, I. N. (141); Alexander, G. (141); Alexopoulos, T. (141); Alhroob, M. (141); Alimonti, G. (141); Alio, L. (141); Aloisio, A. (141); Alonso, F. (141); Alpigiani, C. (141); Altheimer, A. (141); Amako, K. (141); Amelung, C. (141); Amorim, A. (141); Amoroso, S. (141); Amram, N. (141); Amundsen, G. (141); Anastopoulos, C. (141); Ancu, L. S. (141); Andari, N. (141); Andeen, T. (141); Anders, G. (141); Anderson, K. J. (141); Andreazza, A. (141); Angerami, A. (141); Anghinolfi, F. (141); Anjos, N. (141); Annovi, A. (141); Antonelli, M. (141); Antonov, A. (141); Anulli, F. (141); Aoki, M. (141); Arabidze, G. (141); Arai, Y. (141); Argyropoulos, S. (141); Arnaez, O. (141); show less...

University: Stockholm University (294); Uppsala University (244); Lund University (197); Royal Institute of Technology (167); University of Gothenburg (44); Karolinska Institutet (34); show more...; Chalmers University of Technology (25); Umeå University (21); Linköping University (18); Linnaeus University (12); Luleå University of Technology (8); Swedish University of Agricultural Sciences (6); Mid Sweden University (5); RISE (5); Malmö University (4); Örebro University (3); Halmstad University (1); Jönköping University (1); University of Skövde (1); The Swedish School of Sport and Health Sciences (1); Karlstad University (1); Högskolan Dalarna (1); Swedish Museum of Natural History (1); VTI - The Swedish National Road and Transport Research Institute (1); show less...

Language: English (430); Swedish (6); Undefined language (1)

Research subject (UKÄ/SCB): Natural sciences (349); Medical and Health Sciences (66); Engineering and Technology (29); Agricultural Sciences (5); Social Sciences (5); Humanities (1)

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