↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Seaman SA) "

Search: WFRF:(Seaman SA)

Result 1-4 of 4

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
1.	Roxburgh, RHSR, et al. (author) Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity 2005 In: Neurology. - 1526-632X. ; 64:7, s. 1144-1151 Journal article (peer-reviewed)
2.	Sun, ND, et al. (author) Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing 2018 In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 8:1, s. 17509- Journal article (peer-reviewed)abstract Capable of mediating efficient transfection and protein production without eliciting innate immune responses, chemically modified mRNA holds great potential to produce paracrine factors at a physiologically beneficial level, in a spatiotemporally controlled manner, and with low toxicity. Although highly promising in cardiovascular medicine and wound healing, effects of this emerging therapeutic on the microvasculature and its bioactivity in disease settings remain poorly understood. Here, we longitudinally and comprehensively characterize microvascular responses to AZD8601, a modified mRNA encoding vascular endothelial growth factor A (VEGF-A), in vivo. Using multi-parametric photoacoustic microscopy, we show that intradermal injection of AZD8601 formulated in a biocompatible vehicle results in pronounced, sustained and dose-dependent vasodilation, blood flow upregulation, and neovessel formation, in striking contrast to those induced by recombinant human VEGF-A protein, a non-translatable variant of AZD8601, and citrate/saline vehicle. Moreover, we evaluate the bioactivity of AZD8601 in a mouse model of diabetic wound healing in vivo. Using a boron nanoparticle-based tissue oxygen sensor, we show that sequential dosing of AZD8601 improves vascularization and tissue oxygenation of the wound bed, leading to accelerated re-epithelialization during the early phase of diabetic wound healing.
3.	Niemi, MEK, et al. (author) 2021 swepub:Mat__t
4.	Kanai, M, et al. (author) 2023 swepub:Mat__t

Skapa referenser, mejla, bekava och länka

Permalink

Result 1-4 of 4

Refine your search

Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Brown, J. (2); Clark, A. (2); Cole, S. (2); Davies, M. (2); Endo, M. (2); Erdmann, J. (2); show more...; Fox, H. (2); Hasegawa, Y. (2); Hughes, G. (2); Jackson, M. (2); Jackson, P. (2); Karthik, K. (2); Lee, H. (2); Lewis, A. (2); Maeno, T. (2); Saleem, M. (2); Suzuki, Y. (2); Walker, R. (2); White, S. (2); Williams, S. (2); Wilson, A. (2); Wright, M. (2); Wu, Y. (2); Yamada, M. (2); Nagata, K. (2); Davidson, N. (2); Dobson, E. (2); Harvey, A. (2); Lange, C. (2); Oliveira, M. (2); Rose, A. (2); Davies, E. (2); Grau, N. (2); Haider, S. (2); Tokunaga, K. (2); Suzuki, S (2); Gupta, A. (2); Robinson, M. (2); Dennis, C. (2); Marshall, R. (2); Smith, M. (2); Martin, J. (2); Mbarek, H (2); Davies, G (2); Harris, C (2); Kumar, S (2); Brown, A. (2); Brown, E. (2); Clark, M. (2); Hays, C. (2); show less...

University: Karolinska Institutet (3)

Language: English (4)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view