| 1. |
- Ruilope, LM, et al.
(author)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Journal article (peer-reviewed)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 2. |
- Butler-Laporte, G, et al.
(author)
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Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative
- 2022
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In: PLoS genetics. - : Public Library of Science (PLoS). - 1553-7404 .- 1553-7390. ; 18:11, s. e1010367-
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Journal article (peer-reviewed)abstract
- Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the largest impact on COVID-19 outcomes are expected to be rare in the population. Hence, studying rare variants may provide additional insights into disease susceptibility and pathogenesis, thereby informing therapeutics development. Here, we combined whole-exome and whole-genome sequencing from 21 cohorts across 12 countries and performed rare variant exome-wide burden analyses for COVID-19 outcomes. In an analysis of 5,085 severe disease cases and 571,737 controls, we observed that carrying a rare deleterious variant in the SARS-CoV-2 sensor toll-like receptor TLR7 (on chromosome X) was associated with a 5.3-fold increase in severe disease (95% CI: 2.75–10.05, p = 5.41x10-7). This association was consistent across sexes. These results further support TLR7 as a genetic determinant of severe disease and suggest that larger studies on rare variants influencing COVID-19 outcomes could provide additional insights.
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| 3. |
- Wohlfahrt, G., et al.
(author)
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An ecosystem-scale perspective of the net land methanol flux : synthesis of micrometeorological flux measurements
- 2015
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In: Atmospheric Chemistry and Physics. - : Copernicus GmbH. - 1680-7324. ; 15:13, s. 7413-7427
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Journal article (peer-reviewed)abstract
- Methanol is the second most abundant volatile organic compound in the troposphere and plays a significant role in atmospheric chemistry. While there is consensus about the dominant role of living plants as the major source and the reaction with OH as the major sink of methanol, global methanol budgets diverge considerably in terms of source/sink estimates, reflecting uncertainties in the approaches used to model and the empirical data used to separately constrain these terms. Here we compiled micrometeorological methanol flux data from eight different study sites and reviewed the corresponding literature in order to provide a first cross-site synthesis of the terrestrial ecosystem-scale methanol exchange and present an independent data-driven view of the land-atmosphere methanol exchange. Our study shows that the controls of plant growth on production, and thus the methanol emission magnitude, as well as stomatal conductance on the hourly methanol emission variability, established at the leaf level, hold across sites at the ecosystem level. Unequivocal evidence for bi-directional methanol exchange at the ecosystem scale is presented. Deposition, which at some sites even exceeds methanol emissions, represents an emerging feature of ecosystem-scale measurements and is likely related to environmental factors favouring the formation of surface wetness. Methanol may adsorb to or dissolve in this surface water and eventually be chemically or biologically removed from it. Management activities in agriculture and forestry are shown to increase local methanol emission by orders of magnitude; however, they are neglected at present in global budgets. While contemporary net land methanol budgets are overall consistent with the grand mean of the micrometeorological methanol flux measurements, we caution that the present approach of simulating methanol emission and deposition separately is prone to opposing systematic errors and does not allow for full advantage to be taken of the rich information content of micrometeorological flux measurements.
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| 4. |
- Abu-Shaban, Z., et al.
(author)
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Near-field Localization with a Reconfigurable Intelligent Surface Acting as Lens
- 2021
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In: IEEE International Conference on Communications. - 1550-3607. ; June 2021
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Conference paper (peer-reviewed)abstract
- Exploiting wavefront curvature enables localization with limited infrastructure and hardware complexity. With the introduction of reconfigurable intelligent surfaces (RISs), new opportunities arise, in particular when the RIS is functioning as a lens receiver. We investigate the localization of a transmitter using a RIS-based lens in close proximity to a single receive antenna element attached to reception radio frequency chain. We perform a Fisher information analysis, evaluate the impact of different lens configurations, and propose a two-stage localization algorithm. Our results indicate that positional beamforming can lead to better performance when a priori location information is available, while random beamforming is preferred when a priori information is lacking. Our simulation results for a moderate size lens operating at 28 GHz showcased that decimeter-level accuracy can be attained within 3 meters to the lens.
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| 5. |
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| 6. |
- Chen, Hui, 1992, et al.
(author)
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RISs and Sidelink Communications in Smart Cities: The Key to Seamless Localization and Sensing
- 2023
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In: IEEE Communications Magazine. - 0163-6804 .- 1558-1896. ; 61:8, s. 140-146
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Journal article (peer-reviewed)abstract
- A smart city involves, among other elements, intelligent transportation, crowd monitoring, and digital twins, each of which requires information exchange via wireless communication links and localization of connected devices and passive objects (including people). Although localization and sensing (L&S) are envisioned as core functions of future communication systems, they have inherently different demands in terms of infrastructure compared to communications. Wireless communications generally requires a connection to only a single access point (AP), while L&S demand simultaneous line-of-sight propagation paths to several APs, which serve as location and orientation anchors. Hence, a smart city deployment optimized for communication will be insufficient to meet stringent L&S requirements. In this article, we argue that the emerging technologies of reconfigurable intelligent surfaces (RISs) and sidelink communications constitute the key to providing ubiquitous coverage for L&S in smart cities with low-cost and energy-efficient technical solutions. To this end, we propose and evaluate AP-coordinated and self-coordinated RIS-enabled L&S architectures and detail three groups of application scenarios, relying on low-complexity beacons, cooperative localization, and full-duplex transceivers. A list of practical issues and consequent open research challenges of the proposed L&S systems is also provided.
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| 7. |
- Destino, G., et al.
(author)
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Performance Analysis of Hybrid 5G-GNSS Localization
- 2018
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In: Conference Record - Asilomar Conference on Signals, Systems and Computers. - 1058-6393. ; 2018-October, s. 8-12
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Conference paper (peer-reviewed)abstract
- We consider a novel positioning solution combining millimeter wave (mmW) 5G and Global Navigation Satellite System (GNSS) technologies. The study is carried out theoretically by deriving the Fisher Information Matrix (FIM) of a combined 5G-GNSS positioning system and, subsequently, the position, rotation and clock-bias error lower bounds. We pursue a two-step approach, namely, computing first the FIM for the channel parameters, and then transforming it into the FIM of the position, rotation and clock-bias. The analysis shows advantages of the hybrid positioning in terms of i) localization accuracy, ii) coverage, iii) precise rotation estimation and iv) clock-error estimation. In other words, we demonstrate that a tight coupling of the two technologies can provide mutual benefits.
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| 8. |
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| 9. |
- Ghazalian, Reza, et al.
(author)
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Joint 3D User and 6D Hybrid Reconfigurable Intelligent Surface Localization
- 2024
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In: IEEE Transactions on Vehicular Technology. - 0018-9545 .- 1939-9359. ; In Press
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Journal article (peer-reviewed)abstract
- The latest assessments of the emerging technologies for reconfigurable intelligent surfaces (RISs) have indicated the concept's significant potential for localization and sensing, either as individual or simultaneously realized tasks. However, in the vast majority of those studies, the RIS state (i.e., its position and rotation angles) is required to be known a priori. In this paper, we address the problem of the joint three-dimensional (3D) localization of a hybrid RIS (HRIS) and a user. The most cost- and power-efficient hybrid version of an RIS is equipped with a single reception radio-frequency chain and meta-atoms capable of simultaneous reconfigurable reflection and sensing. This dual functionality is controlled by adjustable power splitters embedded at each hybrid meta-atom. Focusing on a downlink scenario where a multi-antenna base station transmits multicarrier signals to a user via an HRIS, we propose a multistage approach to jointly estimate the metasurface's 3D position and 3D rotation matrix (i.e., 6D parameter estimation) as well as the user's 3D position. Our simulation results verify the validity of the proposed estimator via extensive comparisons of the root-mean-square error of the state estimations with the Cram´er-Rao lower bound (CRB), which is analytically derived. Furthermore, it is showcased that there exists an optimal hybrid reconfigurable intelligent surface (HRIS) power splitting ratio for the desired multi-parameter estimation problem. We also study the robustness of the proposed method in the presence of scattering points in the wireless propagation environment.
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| 10. |
- Ghazalian, Reza, et al.
(author)
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Joint User Localization and Location Calibration of A Hybrid Reconfigurable Intelligent Surface
- 2024
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In: IEEE Transactions on Vehicular Technology. - 0018-9545 .- 1939-9359. ; 73:1, s. 1435-1440
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Journal article (peer-reviewed)abstract
- The recent research in the emerging technology of reconfigurable intelligent surfaces (RISs) has identified its high potential for localization and sensing. However, to accurately localize a user placed in the area of influence of an RIS, the RIS location needs to be known a priori and its phase profile is required to be optimized for localization. In this paper, we study the problem of the joint localization of a hybrid RIS (HRIS) and a user, considering that the former is equipped with a single reception radio-frequency (RF) chain enabling simultaneous tunable reflections and sensing via power splitting. Focusing on the downlink of a multi-antenna base station, we present a multi-stage approach for the estimation of the HRIS position and orientation as well as the user position. Our simulation results, including comparisons with the Cramér-Rao lower bounds, demonstrate the efficiency of the proposed localization approach, while showcasing that there exists an optimal HRIS power splitting ratio for the desired multi-parameter estimation problem.
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