| 1. |
- Sendi, P, et al.
(author)
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Streptococcus agalactiae in relapsing cellulitis
- 2007
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In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. - : Oxford University Press (OUP). - 1537-6591. ; 44:8, s. 1141-1142
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Journal article (other academic/artistic)
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| 5. |
- Sendi, P, et al.
(author)
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Group B streptococcus in prosthetic hip and knee joint-associated infections
- 2011
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In: Journal of Hospital Infection. - : Saunders Elsevier. - 0195-6701 .- 1532-2939. ; 79:1, s. 64-69
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Journal article (peer-reviewed)abstract
- The incidence of invasive group B streptococcus (GBS) infections in non-pregnant adults is increasing. Little is known about GBS in periprosthetic joint infections (PJIs). We aimed to analyse the clinical presentation of GBS PJI and its treatment in association with the outcome. The characteristics of 36 GBS PJIs collected from 10 centres were investigated. In 34 episodes, follow-up examination of ≥ 2 years was available, allowing treatment and outcome analysis. Most infections (75%) occurred ≥ 3 months after implantation. Most patients (91%) had at least one comorbidity; 69% presented with acute symptoms and 83% with damaged periprosthetic soft tissue. In 20 of 34 episodes debridement and retention of implant was attempted, but in five of these the prosthesis was ultimately removed. Hence, in 19 (56%) episodes, the implant was removed, including 14 immediate removals. In four episodes the removal was permanent. Penicillin derivatives and clindamycin were the most common antimicrobials administered (68%). In 94% the infection was cured, and in 82% functional mobility preserved. Debridement with implant retention was successful if the duration of symptoms was short, the prosthesis stable, and the tissue damage minor (10/10 vs 3/10 episodes, P = 0.003). Surgery that complied with a published algorithm was associated with a favourable outcome (P = 0.049).
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| 7. |
- Sendi, P, et al.
(author)
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Spinal epidural abscess in clinical practice
- 2008
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In: QJM : monthly journal of the Association of Physicians. - : Oxford University Press (OUP). - 1460-2725. ; 101:1, s. 1-12
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Journal article (peer-reviewed)
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| 8. |
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| 9. |
- Siemens, N, et al.
(author)
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Prothrombotic and Proinflammatory Activities of the β-Hemolytic Group B Streptococcal Pigment
- 2020
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In: Journal of innate immunity. - : S. Karger AG. - 1662-8128 .- 1662-811X. ; 12:4, s. 291-303
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Journal article (peer-reviewed)abstract
- A prominent feature of severe streptococcal infections is the profound inflammatory response that contributes to systemic toxicity. In sepsis the dysregulated host response involves both immunological and nonimmunological pathways. Here, we report a fatal case of an immunocompetent healthy female presenting with toxic shock and purpura fulminans caused by group B streptococcus (GBS; serotype III, CC19). The strain (LUMC16) was pigmented and hyperhemolytic. Stimulation of human primary cells with hyperhemolytic LUMC16 and STSS/NF-HH strains and pigment toxin resulted in a release of proinflammatory mediators, including tumor necrosis factor, interleukin (IL)-1β, and IL-6. In addition, LUMC16 induced blood clotting and showed factor XII activity on its surface, which was linked to the presence of the pigment. The expression of pigment was not linked to a mutation within the CovR/S region. In conclusion, our study shows that the hemolytic lipid toxin contributes to the ability of GBS to cause systemic hyperinflammation and interferes with the coagulation system.
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