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1.	Doehner, Wolfram, et al. (author) Interaction of heart failure and stroke : A clinical consensus statement of the ESC Council on Stroke, the Heart Failure Association (HFA) and the ESC Working Group on Thrombosis 2023 In: European Journal of Heart Failure. - : John Wiley & Sons. - 1388-9842 .- 1879-0844. ; 25:12, s. 2107-2129 Journal article (peer-reviewed)abstract Heart failure (HF) is a major disease in our society that often presents with multiple comorbidities with mutual interaction and aggravation. The comorbidity of HF and stroke is a high risk condition that requires particular attention to ensure early detection of complications, efficient diagnostic workup, close monitoring, and consequent treatment of the patient. The bi-directional interaction between the heart and the brain is inherent in the pathophysiology of HF where HF may be causal for acute cerebral injury, and - in turn - acute cerebral injury may induce or aggravate HF via imbalanced neural and neurovegetative control of cardiovascular regulation. The present document represents the consensus view of the ESC Council on Stroke, the Heart Failure Association and the ESC Working Group on Thrombosis to summarize current insights on pathophysiological interactions of the heart and the brain in the comorbidity of HF and stroke. Principal aspects of diagnostic workup, pathophysiological mechanisms, complications, clinical management in acute conditions and in long-term care of patients with the comorbidity are presented and state-of-the-art clinical management and current evidence from clinical trials is discussed. Beside the physicians perspective, also the patients values and preferences are taken into account. Interdisciplinary cooperation of cardiologists, stroke specialists, other specialists and primary care physicians is pivotal to ensure optimal treatment in acute events and in continued long-term treatment of these patients. Key consensus statements are presented in a concise overview on mechanistic insights, diagnostic workup, prevention and treatment to inform clinical acute and continued care of patients with the comorbidity of HF and stroke.
2.	Weber, Christian, et al. (author) Role and analysis of monocyte subsets in cardiovascular disease Joint consensus document of the European Society of Cardiology (ESC) Working Groups "Atherosclerosis & Vascular Biology" and "Thrombosis" 2016 In: Thrombosis and Haemostasis. - 0340-6245 .- 2567-689X. ; 116:4, s. 626-637 Journal article (peer-reviewed)abstract Monocytes as cells of the innate immunity are prominently involved in the development of atherosclerotic lesions. The heterogeneity of blood monocytes has widely been acknowledged by accumulating experimental and clinical data suggesting a differential, subset-specific contribution of the corresponding subpopulations to the pathology of cardiovascular and other diseases. This document re-evaluates current nomenclature and summarises key findings on monocyte subset biology to propose a consensus statement about phenotype, separation and quantification of the individual subsets.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Lip, Gregory Y H (2); Shantsila, Eduard (2); Siegbahn, Agneta (1); Boehm, Michael (1); Savarese, Gianluigi (1); Metra, Marco (1); show more...; Coats, Andrew J. S. (1); Rosano, Giuseppe (1); Wojta, Johann (1); Ntaios, George (1); Boriani, Giuseppe (1); Christersson, Christ ... (1); Jones, Ian D. (1); Vilahur, Gemma (1); Hoefer, Imo E. (1); Weber, Christian (1); Monaco, Claudia (1); Caligiuri, Giuseppin ... (1); Heine, Gunnar H (1); Peter, Karlheinz (1); Doehner, Wolfram (1); Haeusler, Karl Georg (1); Steffens, Sabine (1); Hristov, Michael (1); Guzik, Tomasz (1); Rainger, Ed (1); show less...

University: Uppsala University (2); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

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