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- Siikanen, Jonathan, et al.
(author)
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A Peristaltic Pump Driven Zr-89 Separation Module
- 2012
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In: 14th International Workshop on Targetry and Target Chemistry. - : AIP. - 1551-7616 .- 0094-243X. ; 1509, s. 206-210
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Conference paper (peer-reviewed)abstract
- To facilitate the separation of Zr-89 produced in yttrium foils, an automated separation module was designed and assembled. The module separates more than 85% of produced Zr-89 - activity in 3 g foils in less than 90 min. About 10 % remains in the dissolving vial. The quality of the separated Zr-89 activity was investigated for labeling of the HER2-binding monoclonal antibody fragment, trastuzumab-Fab.
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- Siikanen, Jonathan, et al.
(author)
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A solid target system with remote handling of irradiated targets for PET cyclotrons.
- 2014
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In: Applied Radiation and Isotopes. - : Elsevier BV. - 0969-8043. ; 94, s. 294-301
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Journal article (peer-reviewed)abstract
- A solid target system was developed for a PET cyclotron. The system is compatible with many different target materials in the form of foils and electroplated/sputtered targets which makes it useful for production of a wide variety of different PET radionuclides. The target material is manually loaded into the system. Remote handling of irradiated target material is managed with a pneumatic piston and a vacuum technique which allows the targets to be dropped into a shielded transport container. To test the target performance, proton irradiations (12.8MeV, 45μA) of monoisotopic yttrium foils (0.64mm, direct water cooling) were performed to produce (89)Zr. The yields were 2200±200MBq (1h, n=13) and 6300±65MBq (3h, n=3).
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