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- Lie, S. O., et al.
(author)
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Long-term results in children with AML: NOPHO-AML Study Group--report of three consecutive trials
- 2005
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In: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 19:12, s. 2090-100
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Journal article (peer-reviewed)abstract
- In all, 447 children with acute myeloid leukaemia (AML) have been treated on three consecutive NOPHO studies from July 1984 to December 2001. NOPHO-AML 84 was of moderate intensity with an induction of three courses of cytarabine, 6-thioguanine and doxorubicin followed by four consolidation courses with high-dose cytarabine. The 5-year event-free survival (EFS), disease free survival (DFS) and overall survival (OS) were 29, 37 and 38%. NOPHO-AML 88 was of high intensity with the addition of etoposide and mitoxantrone in selected courses during induction and consolidation. The interval between the induction courses should be as short as possible, that is, time intensity was introduced. The 5-year EFS, DFS and OS were 41, 48 and 46%. In NOPHO-AML 93, the treatment was stratified according to response to first induction course. The protocol utilised the same induction blocks as NOPHO-AML 88, but after the first block, children with a hypoplastic, nonleukaemic bone marrow were allowed to recover before the second block. Consolidation was identical with NOPHO-AML 88. The 5-year EFS, DFS and OS in NOPHO-AML 93 were 48, 52 and 65%. The new NOPHO-AML protocol has been based on experiences from previous protocols with stratification of patients with regard to in vivo response and specific cytogenetic aberrations.
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- Ljung, R., et al.
(author)
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Treatment of children with haemophilia in Europe: A survey of 20 centres in 16 countries
- 2000
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In: Haemophilia. - : Wiley. - 1351-8216. ; 6, s. 619-624
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Journal article (peer-reviewed)abstract
- A survey was made of the current status of treatment of haemophilic boys at 20 centres in 16 European countries and includes approximately 1500 of the estimated 6500 haemophiliacs in the participating countries. Many mild haemophiliacs are not seen, or seen infrequently, at haemophilia centres and this requires study. Nine of 18 centres provide continuous prophylaxis to 80-100% of their patients, five centres provide it to 55-80% and the remaining four centres to 15-40% of the boys. The median dose given was 6240 U kg-1 year-1 (range 3120-7800). Four centres administered only recombinant concentrates to children with severe haemophilia A, while seven centres administered recombinant concentrates to 75-90% and the remaining centres to less than 50% of the boys (two centres <10%). When asked for the choice of concentrate for a newly diagnosed boy with severe haemophilia A, all but one centre preferred recombinant concentrate. Most boys below 6 years received concentrates via a peripheral vein but three centres preferred a central venous line for 80-100% of the boys. Thirteen of 18 centres applied home treatment to 84-100% of the boys and the remaining five centres to 57-77% of the boys.
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- Bramhagen, Ann-Cathrine, et al.
(author)
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Transferrin receptor in children and its correlation with iron status and types of milk consumption
- 2003
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In: Acta Paediatrica. - : Taylor & Francis. - 0803-5253 .- 1651-2227. ; 92:6, s. 671-675
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Journal article (peer-reviewed)abstract
- Syfte: Denna studie jämförde koncentrationen av transferrin receptor (TfR) med järnstatus parametrar i relation till barnets intag av komjölk och välling. Metod: TfR, β-Haemoglobin, serum ferritin och medelcellsvolumen (MCV) på de röda blodkropparna analyserades i en population av 263 barn i åldern 2.5 år. Mängden komjölk och välling som barnet drack registrerades. Resultat: Det fanns en signifikant skillnad i TfR/log. ferritin mellan barn vars intag av komjölk var < 500 ml respektive barn med intag av mjölk > 500 ml (p= 0.003). Där fanns ett signifikant högre värde av TfR/log. ferritin bland barn med en medelscellsvolum av de röda blodkropparna på < 75fL jämfört med de som hade > 75fL (p=<0.0001). Koncentrationen av TfR var signifikant högre efter järnbehandling. Konklusion: Högre koncentrationer av TfR var korrelerade med lägre koncentrationer av haemoglobin och MCV av röda bloda kroppar. Mjölk konsumtion ökade risken för högre kvot av TfR/log ferritin. TfR koncentrationen var signifikant lägre efter järnbehandling.
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