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Träfflista för sökning "WFRF:(Silver Daniel) "

Search: WFRF:(Silver Daniel)

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1.
  • Sumaila, U. Rashid, et al. (author)
  • WTO must ban harmful fisheries subsidies
  • 2021
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 374:6567, s. 544-544
  • Journal article (other academic/artistic)
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2.
  • Maurer, Mathew S., et al. (author)
  • Genotype and Phenotype of Transthyretin Cardiac Amyloidosis THAOS (Transthyretin Amyloid Outcome Survey)
  • 2016
  • In: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 68:2, s. 161-172
  • Journal article (peer-reviewed)abstract
    • Background: Transthyretin amyloidosis (ATTR) is a heterogeneous disorder with multiorgan involvement and a genetic or nongenetic basis.Objectives: The goal of this study was to describe ATTR in the United States by using data from the THAOS (Transthyretin Amyloidosis Outcomes Survey) registry.Methods: Demographic, clinical, and genetic features of patients enrolled in the THAOS registry in the United States (n = 390) were compared with data from patients from other regions of the world (ROW) (n = 2,140). The focus was on the phenotypic expression and survival in the majority of U.S. subjects with valine-to-isoleucine substitution at position 122 (Val122Ile) (n = 91) and wild-type ATTR (n = 189).Results: U.S. subjects are older (70 vs. 46 years), more often male (85.4% vs. 50.6%), and more often of African descent (25.4% vs. 0.5%) than the ROW. A significantly higher percentage of U.S. patients with ATTR amyloid seen at cardiology sites had wild-type disease than the ROW (50.5% vs. 26.2%). In the United States, 34 different mutations (n = 201) have been reported, with the most common being Val122Ile (n = 91; 45.3%) and Thr60Ala (n = 41; 20.4%). Overall, 91 (85%) of 107 patients with Val122Ile were from the United States, where Val122Ile subjects were younger and more often female and black than patients with wild-type disease, and had similar cardiac phenotype but a greater burden of neurologic symptoms (pain, numbness, tingling, and walking disability) and worse quality of life. Advancing age and lower mean arterial pressure, but not the presence of a transthyretin mutation, were independently associated with higher mortality from a multivariate analysis of survival.Conclusions: In the THAOS registry, ATTR in the United States is overwhelmingly a disorder of older adult male subjects with a cardiac-predominant phenotype. Val122Ile is the most common transthyretin mutation, and neurologic phenotypic expression differs between wild-type disease and Val122Ile, but survival from enrollment in THAOS does not. (Transthyretin-Associated Amyloidoses Outcome Survey [THAOS]; NCT00628745)
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  • Result 1-10 of 300
Type of publication
journal article (298)
conference paper (1)
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peer-reviewed (296)
other academic/artistic (4)
Author/Editor
Aad, G (281)
Abbott, B. (281)
Abdinov, O (281)
Adye, T. (281)
Albrand, S. (281)
Aleksa, M. (281)
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Aleksandrov, I. N. (281)
Alexander, G. (281)
Alexopoulos, T. (281)
Amako, K. (281)
Amelung, C. (281)
Amram, N. (281)
Anastopoulos, C. (281)
Anderson, K. J. (281)
Antonelli, M. (281)
Arabidze, G. (281)
Arai, Y. (281)
Arnaez, O. (281)
Asai, S. (281)
Asquith, L. (281)
Assamagan, K. (281)
Avolio, G. (281)
Bachacou, H. (281)
Backes, M. (281)
Baines, J. T. (281)
Baker, O. K. (281)
Banas, E. (281)
Barisonzi, M. (281)
Barklow, T. (281)
Barlow, N. (281)
Barnett, R. M. (281)
Batley, J. R. (281)
Bauer, F. (281)
Beau, T. (281)
Beck, H. P. (281)
Bella, G. (281)
Beltramello, O. (281)
Benary, O. (281)
Benekos, N. (281)
Benhammou, Y. (281)
Beringer, J. (281)
Berry, T. (281)
Bilokon, H. (281)
Blair, R. E. (281)
Blumenschein, U. (281)
Bocci, A. (281)
Boehler, M. (281)
Boisvert, V. (281)
Bold, T. (281)
Boonekamp, M. (281)
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Lund University (285)
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English (299)
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Natural sciences (285)
Medical and Health Sciences (11)
Social Sciences (2)
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