| 1. |
- Robinson, Yohan, 1977, et al.
(author)
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Does climate change transform military medicine and defense medical support?
- 2023
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In: Frontiers In Public Health. - 2296-2565. ; 11
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Research review (peer-reviewed)abstract
- Background: Climate change has effects on multiple aspects of human life, such as access to food and water, expansion of endemic diseases as well as an increase of natural disasters and related diseases. The objective of this review is to summarize the current knowledge on climate change effects on military occupational health, military healthcare in a deployed setting, and defense medical logistics. Methods: Online databases and registers were searched on August 22nd, 2022 and 348 papers retrieved, published between 2000 and 2022, from which we selected 8 publications that described climate effects on military health. Papers were clustered according to a modified theoretical framework for climate change effects on health, and relevant items from each paper were summarized. Results: During the last decades a growing body of climate change related publications was identified, which report that climate change has a significant impact on human physiology, mental health, water- and vector borne infectious diseases, as well as air pollution. However, regarding the specific climate effects on military health the level of evidence is low. The effects on defense medical logistics include vulnerabilities in the cold supply chain, in medical devices functioning, in need for air conditioning, and in fresh water supply. Conclusions: Climate change may transform both the theoretical framework and practical implementations in military medicine and military healthcare systems. There are significant knowledge gaps on climate change effects on the health of military personnel in operations of both combat and non-combat nature, alerting the need for prevention and mitigation of climate-related health issues. Further research within the fields of disaster and military medicine is needed to explore this novel field. As climate effects on humans and the medical supply chain may degrade military capability, significant investments in military medical research and development are needed.
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| 2. |
- Sinai, Cave, et al.
(author)
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Exposure to interpersonal violence and risk of post-traumatic stress disorder among women with borderline personality disorder
- 2018
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In: Psychiatry Research. - : ELSEVIER IRELAND LTD. - 0165-1781 .- 1872-7123. ; 262, s. 311-315
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Journal article (peer-reviewed)abstract
- Background: This study aims to determine the validity of the Karolinska Interpersonal Violence Scale (KIVS), as a screening tool for PTSD, among women with borderline personality disorder (BPD) and severe suicidal behavior. Method: 106 women with BPD and at least two suicide attempts were assessed with the KIVS for exposure to interpersonal violence as a child and as an adult. The screening ability of the KIVS for the diagnosis of PTSD was analyzed using receiver operating characteristic curve analysis. Results: PTSD diagnosis was valid for 61 (58%) women with BPD. The KIVS exposure of lifetime interpersonal violence, displayed fair accuracy of predicting diagnosis of PTSD (area under the curve 0.79, confidence interval [0.71, 0.88]) and performed well (sensitivity 0.90 and specificity 0.62), with a cut-off score of 4 (range 0-10). Poly-traumatization was not significantly related to PTSD diagnosis as compared to single traumatization, whereas sexual victimization was significantly more prevalent in women with PTSD diagnosis, as compared to other types of traumatic events. Conclusion: A score of 4 or more on the KIVS exposure to interpersonal lifetime violence presents well as a screening instrument for risk of PTSD, among women with BPD.
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| 3. |
- Sinai, Cave, et al.
(author)
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Hypothalamic pituitary thyroid axis and exposure to interpersonal violence in childhood among women with borderline personality disorder
- 2014
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In: European Journal of Psychotraumatology. - : Informa UK Limited. - 2000-8198 .- 2000-8066. ; 5, s. 23911-
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Journal article (peer-reviewed)abstract
- BACKGROUND: A relationship between exposure to sexual violence and thyroid hormone alterations has been observed among women with posttraumatic stress disorder (PTSD). Women with borderline personality disorder (BPD) report a high estimate of childhood trauma.OBJECTIVE: The aim of the present study was to assess relationships between thyroid hormone measures and exposure to violence in childhood in women with BPD.METHOD: A total of 92 clinically euthyroid women with BPD (53% with comorbid PTSD) diagnosis and at least two prior suicide attempts were assessed with the Karolinska Interpersonal Violence Scales (KIVS). The KIVS contains four subscales with concrete examples of exposure to violence and expressed violent behavior in childhood (aged 6-14 years) and during adult life (15 years or older). Baseline thyroid function was evaluated by measuring plasma free and bound triiodothyronine (FT3 and T3), thyroxine (FT4 and T4), and thyroid-stimulating hormone (TSH) with immunoassays. The FT3/FT4 ratio was used to estimate peripheral deiodination. Plasma cortisol was also assessed.RESULTS: Sixty-seven percent of patients reported medium high or high level of exposure to interpersonal violence as a child. The FT3/FT4 ratio showed a significant negative correlation with exposure to violence as a child. Patients with PTSD had significantly higher plasma cortisol levels. An ad hoc analysis revealed that the correlation between KIVS exposure to interpersonal violence as a child and FT3/FT4 ratio was significant only in patients with comorbid PTSD. Altered thyroid activity, especially FT3/FT4, levels was associated with exposure to violence in childhood in women with BPD.CONCLUSION: Severe childhood trauma-related stress may promote lasting altered thyroid levels and/or contribute to the development of psychopathology associated with BPD traits or PTSD.
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| 4. |
- Sinai, Cave, et al.
(author)
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Thyroid hormones and adult interpersonal violence among women with borderline personality disorder
- 2015
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In: Psychiatry Research. - : Elsevier. - 0165-1781 .- 1872-7123. ; 227:2-3, s. 253-257
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Journal article (peer-reviewed)abstract
- Elevated T3 levels have been reported in men with antisocial behavior. The aim of the present study was to investigate the relationship between thyroid hormones and expressed adult interpersonal violence in female patients with borderline personality disorder (BPD). Furthermore, expressed adult interpersonal violence in female BPD patients was compared to healthy female controls. A total of 92 clinically euthyroid women with BPD and 57 healthy women were assessed with the Karolinska Interpersonal Violence Scales (KIVS). Baseline thyroid function was evaluated by measuring plasma free and bound triiodothyronine (FT3 and T3), thyroxine (FT4 and T4), and thyroid-stimulating hormone (TSH) with immunoassays in patients. Plasma cortisol was also measured. Among females with BPD, expressed interpersonal violence as an adult showed a significant positive correlation with the T3 levels. The mean expression of interpersonal violence as an adult was significantly higher in BPD patients as compared to healthy controls. The multiple regression model indicated that two independent predictors of KIVS expressed interpersonal violence as an adult: T3 and comorbid diagnosis of alcohol abuse. Association between T3 levels and violent/aggressive behavior earlier reported exclusively in male samples may be valid also in females with BPD. (C) 2015 The Authors. Published by Elsevier Ireland Ltd. This is an open access article under the CC BY-NCND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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| 5. |
- Sinai, Cave
(author)
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Thyroid hormones, interpersonal violence and personality traits : clinical studies in high-risk psychiatric cohorts
- 2015
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Doctoral thesis (other academic/artistic)abstract
- Suicidal and violent behaviors as well as early life adversity are prevalent in clinical high-risk populations. Early life adversity is related to developmental dysregulation of behavioral and emotional traits. The neuroendocrine systems involved in the development of dysfunctional behavior and impulsive aggressive traits are not fully known. The overall aim of this thesis was to investigate the relationship between thyroid hormones and personality traits, as well as to exposure to interpersonal violence and violent behavior in two high-risk cohorts of patients with a history of suicide attempts. In study I we investigated personality traits assessed by the Karolinska Scales of Personalityin relation to peripheral thyroid hormones in 100 euthyroid suicide attempters. In studies II and III, we studied the relationship between exposure to, and expression of interpersonal violence and adult levels of thyroid and cortisol hormones in 92 clinically euthyroid women with borderline personality disorder (BPD), with at least two prior suicide attempts. The Karolinska Interpersonal Violence Scale was used to assess exposure to, and expression of interpersonal violence. Baseline thyroid function was evaluated by measuring plasma free and bound triiodothyronine (FT3 and T3), thyroxine (FT4 and T4), and thyroidstimulating hormone (TSH) with immunoassays. The FT3/FT4 ratio was used to estimate the peripheral deiodination. Plasma cortisol was also measured. In study IV we investigated the screening validity of the Karolinska Interpersonal Violence Scale, in predicting post-traumatic stress disorder (PTSD) in 106 women with BPD, with at least two prior suicide attempts. In study I, we found that in male suicide attempters, the T3/FT4 ratio was negatively correlated to Aggressiveness and positively correlated to Detachment. In study II, 67% of women with BPD reported Medium High or High levels of exposure to interpersonal violence as a child. The FT3/FT4 ratio showed a significant negative correlation with exposure to violence as a child. Patients with PTSD had significantly higher plasma cortisol levels. In study III, the mean expression of interpersonal violence as an adult was significantly higher in BPD patients as compared to healthy controls. Adult expression of interpersonal violence among females with BPD, showed a significant positive correlation with the T3 levels. T3 and comorbid diagnosis of alcohol abuse were independent predictors of adult expression of interpersonal violence. In study IV, the PTSD diagnosis was valid for (58%) women with BPD. The KIVS – exposure of lifetime interpersonal violence, displayed a fair accuracy of predicting diagnosis of PTSD. Our findings indicate that peripheral thyroid hormones may be associated with early life adversity, adult aggressive traits and interpersonal violence in clinical high-risk psychiatric populations. Karolinska Interpersonal Violence Scale may be used for PTSD screening.
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