| 1. |
- Sinderholm Sposato, Niklas, 1977, et al.
(författare)
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Effectiveness of manual therapy interventions in cystic fibrosis care: a pilot study
- 2024
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Ingår i: JOURNAL OF BODYWORK AND MOVEMENT THERAPIES. - 1360-8592 .- 1532-9283. ; 39, s. 323-329
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Tidskriftsartikel (refereegranskat)abstract
- Background: Cystic fibrosis (CF) is a severe genetic condition that affects multiple organ systems and imposes a substantial treatment burden. Regarding the lungs and airways, the progressive pathophysiological changes place a significant strain on the musculoskeletal components of the respiratory system for people with CF. This pilot study investigated the effectiveness of manual therapy interventions (MTIs) on thoracic mobility, respiratory muscle strength, lung function, and musculoskeletal pain. Method: A study with a pretest-posttest design was conducted with 15 eligible people with CF at the Sahlgrenska University Hospital CF Centre. After an initial set of diagnostic tests at baseline, the participants underwent eight weekly 30-min MTIs. The MTIs included passive joint mobilisation and soft tissue manipulation of primary and secondary anatomical areas of the musculoskeletal respiratory system. On the day of the final intervention, the baseline measurements were repeated. Results: Trends of increased thoracic mobility were observed following the intervention, with a statistically significant increase in respiratory muscle strength. No change in lung function was observed. Musculoskeletal pain before and after the intervention showed a significant decrease in tender points, and all participants reported positive experiences with MTIs. Conclusion: MTIs may improve thoracic mobility, alleviate pain, and enhance respiratory muscle strength in people with CF. Further research is needed to confirm their potential role as a CF physiotherapy supplement. Clinical trial id: NCT04696198.
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| 2. |
- Sinderholm Sposato, Niklas, 1977, et al.
(författare)
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Manual therapies in cystic fibrosis care: a scoping review
- 2023
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Ingår i: Chiropractic & Manual Therapies. - : Springer Science and Business Media LLC. - 2045-709X. ; 31:1
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Tidskriftsartikel (refereegranskat)abstract
- ObjectivesTo review the use of manual therapies (MT) for pain, respiratory muscle strength and pulmonary function in cystic fibrosis (CF) care.MethodsA search with a systematic approach was conducted by two independent reviewers, using the databases Medline, PubMed, Scopus and Cinahl from their respective inception dates to March 2021.ResultsA total of 199 publications were initially screened by title and abstract, after which 190 were excluded. Following a full-text review of the remaining articles, six studies with a total of 234 participants were included. Decreased pain levels following MT were observed in two studies and, in three studies, patient reports on improvement in ease of breathing and peak airflow were presented. No significant effects on spirometry measures were observed and none of the included studies investigated respiratory muscle strength.ConclusionCurrent research on MT in CF care indicates positive trends based on subjective measures. However, research in this context is sparse and disparate in terms of both interventions and methodology. Further investigations including MT as part of multimodal interventions are therefore suggested before any specific recommendations for clinical implementation of MT in CF can be provided.
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| 3. |
- Sinderholm Sposato, Niklas, 1977, et al.
(författare)
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Musculoskeletal aspects of respiratory function in cystic fibrosis: a cross-sectional comparative study
- 2024
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Ingår i: EUROPEAN CLINICAL RESPIRATORY JOURNAL. - 2001-8525. ; 11:1
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Tidskriftsartikel (refereegranskat)abstract
- BackgroundRespiration is an intricate interaction between visceral and musculoskeletal structures. In cystic fibrosis (CF), the airways and lungs are subject to progressive obstruction and destruction. However, knowledge about the musculoskeletal aspects of respiratory function and symptoms is still limited in this patient group.MethodsIn a cross-sectional comparative study, 21 adults with CF enrolled at the Gothenburg CF Centre were matched with 42 healthy controls. The two groups were examined and compared in terms of thoracic mobility, respiratory muscle strength, lung function, and musculoskeletal pain in accordance with a predefined protocol.ResultsSignificant differences were observed between the groups in the number of tender points, thoracic excursion, forced vital capacity (FVC), and forced expiratory volume (FEV). The CF group also demonstrated a tendency toward reduced function in other measurements, although these were not statistically significant.ConclusionThis cross-sectional study revealed that people with CF have reduced thoracic mobility and an increased prevalence of muscular tender points, alongside decreased lung function, compared to healthy controls. These findings stress the need for greater emphasis on the often-overlooked musculoskeletal aspects of CF care, especially as people with CF are living longer and may require more musculoskeletal health support.
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| 4. |
- Sinderholm Sposato, Niklas, 1977, et al.
(författare)
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Thoracic configuration in patients ageing with cystic fibrosis: A retrospective single-blinded cohort study.
- 2023
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Ingår i: Respiratory physiology & neurobiology. - : Elsevier BV. - 1569-9048 .- 1878-1519. ; 307
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Tidskriftsartikel (refereegranskat)abstract
- In patients with cystic fibrosis (CF), thoracic morphology and its role in respiratory function is conditioned by anthropometric factors, as well as by pathological changes. While the lungs are continuously monitored, examinations of potential thoracic cage adaptations to the disease are rare. Hence, the aim of this study was to investigate thoracic configuration, and its correlation to spirometry measures over time.In total, 344 high-resolution computed tomography (HRCT) examinations from 90 patients were assessed and analysed. Those results were subsequently related to spirometry measurements performed within the same period.The cohort displayed no homogenous change in thoracic configuration over time, and correlation between thoracic area and spirometry variables could not be supported statistically.Although the current study included a larger cohort of patients with CF compared to previous studies on thoracic morphology, no patient group-specific changes in thoracic configuration were revealed. Furthermore, no correlations between structural findings and functional respiratory measurements were found.
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