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Träfflista för sökning "WFRF:(Singh Sasha A.) "

Search: WFRF:(Singh Sasha A.)

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1.
  • 2019
  • Journal article (peer-reviewed)
  •  
2.
  • Kehoe, Laura, et al. (author)
  • Make EU trade with Brazil sustainable
  • 2019
  • In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
  • Journal article (other academic/artistic)
  •  
3.
  • Engelbrecht, Eric, et al. (author)
  • Sphingosine 1-phosphate-regulated transcriptomes in heterogenous arterial and lymphatic endothelium of the aorta
  • 2020
  • In: eLIFE. - : ELIFE SCIENCES PUBLICATIONS LTD. - 2050-084X. ; 9
  • Journal article (peer-reviewed)abstract
    • Despite the medical importance of G protein-coupled receptors (GPCRs), in vivo cellular heterogeneity of GPCR signaling and downstream transcriptional responses are not understood. We report the comprehensive characterization of transcriptomes (bulk and single-cell) and chromatin domains regulated by sphingosine 1-phosphate receptor-1 (S1PR1) in adult mouse aortic endothelial cells. First, S1PR1 regulates NF kappa B and nuclear glucocorticoid receptor pathways to suppress inflammation-related mRNAs. Second, S1PR1 signaling in the heterogenous endothelial cell (EC) subtypes occurs at spatially-distinct areas of the aorta. For example, a transcriptomically distinct arterial EC population at vascular branch points (aEC1) exhibits ligand-independent S1PR1/beta-arrestin coupling. In contrast, circulatory S1P-dependent S1PR1/beta-arrestin coupling was observed in non-branch point aEC2 cells that exhibit an inflammatory gene expression signature. Moreover, S1P/S1PR1 signaling regulates the expression of lymphangiogenic and inflammation-related transcripts in an adventitial lymphatic EC (LEC) population in a ligand-dependent manner. These insights add resolution to existing concepts of endothelial heterogeneity, GPCR signaling and S1P biology.
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  • Result 1-3 of 3
Type of publication
journal article (3)
Type of content
peer-reviewed (2)
other academic/artistic (1)
Author/Editor
Kelly, Daniel (1)
Bengtsson-Palme, Joh ... (1)
Nilsson, Henrik (1)
Kelly, Ryan (1)
Li, Ying (1)
Moore, Matthew D. (1)
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Rothhaupt, Karl-Otto (1)
Liu, Fang (1)
Zhang, Yao (1)
Jin, Yi (1)
Raza, Ali (1)
Rafiq, Muhammad (1)
Zhang, Kai (1)
Khatlani, T (1)
Kahan, Thomas (1)
Weigend, Maximilian (1)
Müller, Jörg (1)
Farrell, Katharine N ... (1)
Sörelius, Karl, 1981 ... (1)
Batra, Jyotsna (1)
Roobol, Monique J (1)
Backman, Lars (1)
Yan, Hong (1)
Islar, Mine (1)
Krause, Torsten (1)
Uddling, Johan, 1972 (1)
Alexanderson, Helena (1)
Schneider, Christoph (1)
Schmidt, Axel (1)
Battiston, Roberto (1)
Lorkowski, Stefan (1)
Thrift, Amanda G. (1)
Zhang, Wei (1)
Hammerschmidt, Sven (1)
Patil, Chandrashekha ... (1)
Wang, Jun (1)
Lukic, Marko (1)
Pollesello, Piero (1)
Conesa, Ana (1)
Pereira, Laura (1)
El-Esawi, Mohamed A. (1)
Riggi, Laura (1)
Cattaneo, Claudio (1)
Zhang, Weijia (1)
Jung, Martin (1)
Andresen, Louise C. (1)
Kasimir, Åsa (1)
Wang-Erlandsson, Lan (1)
Li, Jian (1)
Marinello, Francesco (1)
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University
Uppsala University (2)
Lund University (2)
Chalmers University of Technology (2)
Karolinska Institutet (2)
University of Gothenburg (1)
Royal Institute of Technology (1)
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Halmstad University (1)
Stockholm University (1)
Mid Sweden University (1)
Swedish University of Agricultural Sciences (1)
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Language
English (3)
Research subject (UKÄ/SCB)
Natural sciences (2)
Medical and Health Sciences (2)
Engineering and Technology (1)
Social Sciences (1)

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