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- Ahlm, Kristin, et al.
(author)
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Unnatural deaths in reindeer-herding Sami families in Sweden, 1961-2001
- 2010
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In: International Journal of Circumpolar Health. - 1239-9736 .- 2242-3982. ; 69:2, s. 129-137
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Journal article (peer-reviewed)abstract
- OBJECTIVES: Unnatural deaths among Indigenous populations, including the Swedish Sami, occur more often than among the general population. To find prevention strategies, we explored the circumstances of the unnatural deaths of members of reindeer-herding Sami families.STUDY DESIGN: The number of deaths from among a cohort of 7,482 members of reindeer-herding Sami families were retrieved from the National Board of Health and Welfare for the years 1961- 2001.METHODS: An evaluation of the information from autopsy records at the National Board of Forensic Medicine, police reports, and available medical records identified 158 unnatural deaths. These were then analysed in detail.RESULTS: Transport-related deaths and suicides were the most common unnatural deaths among Swedish reindeer-herding Sami family members. Suicides contributed to 23% of all deaths, road traffic accidents to 16%, and snowmobile fatalities to 11%. The accidents generally reflected an "outdoor lifestyle" and the working conditions were characterized by the use of off-road vehicles such as snowmobiles. Half of the number of victims tested positive for alcohol and alcohol abuse was documented in 15% of all victims.CONCLUSIONS: The results indicate that alcohol is an important factor in preventing unnatural deaths among reindeer-herding Sami, together with increased safety of both on-road and off-road transportation.
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| 3. |
- Ahmed, Lamis, et al.
(author)
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Evaluation and analysis of laboratory tests of bolts-anchored, steel-fiber-reinforced shotcrete linings
- 2017
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In: Proceedings of the World Tunnel Congress 2017. - : International Tunnelling Association.
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Conference paper (peer-reviewed)abstract
- Results from laboratory tests on statically loaded bolt-anchored, steel-fibre-reinforced shotcrete linings in interaction with rock are here evaluated using a 2D finite element model. Calculations are made to determine the state of stress in the rock-shotcrete interface near the rock joints. Plane-stress elements are used with a non-linear material model, capable of describing cracking and de-bonding during loading. The simulated crack position and force-displacement curves are compared with laboratory test results. Since most construction work in underground hard rock involves the use of explosives for excavation work, dynamic load cases are also analysed and compared to results from previous research on vibration resistance of shotcrete.
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- Alao, John Patrick, 1973, et al.
(author)
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Caffeine stabilises fission yeast Wee1 in a Rad24-dependent manner but attenuates Its expression in response to DNA damage.
- 2020
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In: Microorganisms. - : MDPI AG. - 2076-2607. ; 8:10
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Journal article (peer-reviewed)abstract
- The widely consumed neuroactive compound caffeine has generated much interest due to its ability to override the DNA damage and replication checkpoints. Previously Rad3 and its homologues was thought to be the target of caffeine's inhibitory activity. Later findings indicate that the Target of Rapamycin Complex 1 (TORC1) is the preferred target of caffeine. Effective Cdc2 inhibition requires both the activation of the Wee1 kinase and inhibition of the Cdc25 phosphatase. The TORC1, DNA damage, and environmental stress response pathways all converge on Cdc25 and Wee1. We previously demonstrated that caffeine overrides DNA damage checkpoints by modulating Cdc25 stability. The effect of caffeine on cell cycle progression resembles that of TORC1 inhibition. Furthermore, caffeine activates the Sty1 regulated environmental stress response. Caffeine may thus modulate multiple signalling pathways that regulate Cdc25 and Wee1 levels, localisation and activity. Here we show that the activity of caffeine stabilises both Cdc25 and Wee1. The stabilising effect of caffeine and genotoxic agents on Wee1 was dependent on the Rad24 chaperone. Interestingly, caffeine inhibited the accumulation of Wee1 in response to DNA damage. Caffeine may modulate cell cycle progression through increased Cdc25 activity and Wee1 repression following DNA damage via TORC1 inhibition, as TORC1 inhibition increased DNA damage sensitivity.
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| 5. |
- Alao, John Patrick, 1973, et al.
(author)
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Caffeine stabilizes Cdc25 independently of Rad3 in Schizosaccharomyces pombe contributing to checkpoint override
- 2014
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In: Molecular Microbiology. - : Wiley. - 0950-382X .- 1365-2958. ; 92:4, s. 777-796
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Journal article (peer-reviewed)abstract
- Cdc25 is required for Cdc2 dephosphorylation and is thus essential for cell cycle progression. Checkpoint activation requires dual inhibition of Cdc25 and Cdc2 in a Rad3-dependent manner. Caffeine is believed to override activation of the replication and DNA damage checkpoints by inhibiting Rad3-related proteins in both Schizosaccharomyces pombe and mammalian cells. In this study, we have investigated the impact of caffeine on Cdc25 stability, cell cycle progression and checkpoint override. Caffeine induced Cdc25 accumulation in S.pombe independently of Rad3. Caffeine delayed cell cycle progression under normal conditions but advanced mitosis in cells treated with replication inhibitors and DNA-damaging agents. In the absence of Cdc25, caffeine inhibited cell cycle progression even in the presence of hydroxyurea or phleomycin. Caffeine induces Cdc25 accumulation in S.pombe by suppressing its degradation independently of Rad3. The induction of Cdc25 accumulation was not associated with accelerated progression through mitosis, but rather with delayed progression through cytokinesis. Caffeine-induced Cdc25 accumulation appears to underlie its ability to override cell cycle checkpoints. The impact of Cdc25 accumulation on cell cycle progression is attenuated by Srk1 and Mad2. Together our findings suggest that caffeine overrides checkpoint enforcement by inducing the inappropriate nuclear localization of Cdc25.
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| 7. |
- Allard, Christina, et al.
(author)
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Rasbiologiskt språkbruk i statens rättsprocess mot sameby : DN Debatt 2015-06-11
- 2015
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Other publication (pop. science, debate, etc.)abstract
- Statens hantering av forskningsresultat i rättsprocessen med Girjas sameby utgör ett hot mot Sverige som rättsstat och kunskapsnation. Åratal av svensk och internationell forskning underkänns och man använder ett språkbruk som skulle kunna vara hämtat från rasbiologins tid. Nu måste staten ta sitt ansvar och börja agera som en demokratisk rättsstat, skriver 59 forskare.
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| 8. |
- Almasri, Abdullah, 1965-, et al.
(author)
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A wavelet-based panel unit-root test in the presence of an unknown structural break and cross-sectional dependency, with an application of purchasing power parity theory in developing countries
- 2017
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In: Applied Economics. - : Taylor & Francis. - 0003-6846 .- 1466-4283. ; 49:21, s. 2096-2105
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Journal article (peer-reviewed)abstract
- This article introduces two different non-parametric wavelet-based panel unit-root tests in the presence of unknown structural breaks and cross-sectional dependencies in the data. These tests are compared with a previously suggested non-parametric wavelet test, the parameteric Im-Pesaran and Shin (IPS) test and a Wald type of test. The results from the Monte Carlo simulations clearly show that the new wavelet-ratio tests are superior to the traditional tests both in terms of size and power in panel unit-root tests because of its robustness to cross-section dependency and structural breaks. Based on an empirical Central American panel application, we can, in contrast to previous research (where bias due to structural breaks is simply disregarded), find strong, clear-cut support for purchasing power parity (PPP) in this developing region.
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| 9. |
- Altenhoff, Adrian M., et al.
(author)
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Standardized benchmarking in the quest for orthologs
- 2016
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In: Nature Methods. - 1548-7091 .- 1548-7105. ; 13:5, s. 425-
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Journal article (peer-reviewed)abstract
- Achieving high accuracy in orthology inference is essential for many comparative, evolutionary and functional genomic analyses, yet the true evolutionary history of genes is generally unknown and orthologs are used for very different applications across phyla, requiring different precision-recall trade-offs. As a result, it is difficult to assess the performance of orthology inference methods. Here, we present a community effort to establish standards and an automated web-based service to facilitate orthology benchmarking. Using this service, we characterize 15 well-established inference methods and resources on a battery of 20 different benchmarks. Standardized benchmarking provides a way for users to identify the most effective methods for the problem at hand, sets a minimum requirement for new tools and resources, and guides the development of more accurate orthology inference methods.
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| 10. |
- Andersson, Emma, et al.
(author)
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En väg ut ur våldet : KIBB — behandling för familjer där fysisk barnmisshandel förekommit
- 2020
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Reports (other academic/artistic)abstract
- Majoriteten av de barn i Sverige som kommer till socialtjänstens kännedom på grund av misstänkt barnmisshandel fortsätter bo kvar hemma hos sina föräldrar. För de flesta barn gäller detta utan att våldet bearbetats eller att oron för nytt våld har försvunnit.Barnkonventionen är tydlig – ”barnet ska skyddas mot alla former av fysiskt eller psykiskt våld”. Samtidigt omfattar flera av de globala målen i Agenda 2030 barns hälsa och utveckling och ett av dem är att eliminera alla former av våld mot barn (mål 16:2).KIBB (Kognitiv Integrerad Behandling vid Barnmisshandel) är en behandlingsinsats för familjer där det finns misstanke om barnmisshandel. Det är den enda metoden i Sverige som erbjuder hjälp till såväl barnen, föräldrarna och hela familjen samtidigt. KIBB innehåller tre parallella behandlingar:Barnet får bearbeta sina upplevelserDen våldsutövande föräldern lär sig nya positiva föräldrastrategierHela familjen får familjebehandlingForskning från 2019 som undersökte effekterna av KIBB visar att föräldrars våldsutövande minskade signifikant efter avslutad behandling. Den här publikationen ger en inblick i behandlingsinsatsen KIBB ur såväl barns som olika yrkesverksammas perspektiv. Den innehåller också en sammanfattning av två forskningsstudier om KIBB.Hur KIBB går till:Bedrivs i öppenvård med en träff i veckanBarn och föräldrar har var sin behandlare som de sitter enskilt med. Varje session avslutas med att alla är samlade.Behandlingen följer en strukturerad behandlingsmanual med 16 olika sessioner att gå igenom, en per vecka.Våldet och föräldrarnas strategier är i fokus under hela behandlingen
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