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- Skjonsberg, A, et al.
(author)
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A guinea pig strain with recessive heredity of deafness, producing normal-hearing heterozygotes with resistance to noise trauma
- 2005
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In: Audiology & neuro-otology. - : S. Karger AG. - 1420-3030. ; 10:6, s. 323-330
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Journal article (peer-reviewed)abstract
- A new strain of waltzing guinea pigs arose spontaneously in a guinea pig breeding facility in Germany in 1996. In addition to obvious vestibular dysfunction, the waltzing animals appear deaf already at birth. Histological analysis revealed that the waltzers lack an open scala media due to the collapse of Reissner’s membrane onto the surface of the hearing organ. Subsequent breeding has shown that this strain has a recessive mode of inheritance. The homozygotes are deaf and display a waltzing behaviour throughout their lives while the heterozygotes show no significant signs of inner ear injury despite being carriers of this specific mutated gene of hearing impairment. However, the heterozygous animals offer the opportunity to study how hereditary factors interact with auditory stress. In the present study, the susceptibility of the carriers to noise was investigated. Auditory brainstem responses were obtained prior to and after noise exposure (4 kHz, 110 dB, 6 h). The carriers were significantly less affected by the noise as compared to control animals. This difference was still significant at 4 weeks following noise exposure. It is suggested that the heterozygous animals have an endogenous resistance to auditory stress.
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- Skjonsberg, A., et al.
(author)
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Sensitivity and Specificity of Automated Audiometry in Subjects with Normal Hearing or Hearing Impairment
- 2019
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In: Noise & Health. - : Medknow. - 1463-1741 .- 1998-4030. ; 21:98, s. 1-6
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Journal article (peer-reviewed)abstract
- Objective: To investigate the sensitivity and specificity in an automatic computer-controlled audiometric set-up, used for screening purposes. Design: Comparison between standardized audiometry and automated audiometry performed in the same participants. Study Sample: In total, 100 participants (51 females and 49 males) were recruited to take part of this study the same day they visited the hearing clinic for clinical audiometry. Ages varied between 18 and 84 years (mean 45.9 in females, 52.3 in males). Results: The participants were divided into groups, dependent of type of hearing. A total of 23 had normal hearing, 40 had sensorineural hearing loss, 19 had conductive hearing loss and 18 showed asymmetric hearing loss. The sensitivity for the automated audiometry was 86%-100% and the specificity 56%-100%. The group with conductive hearing loss showed the poorest sensitivity (86 %) and specificity (56 %). The group with sensorineural hearing loss showed the smallest variation in difference between the two methods. Conclusions: The results show that automated audiometry is a method suitable to screen for hearing loss. Screening levels need to be selected with respect to cause of screening and environmental factors. For patients with asymmetric hearing thresholds it is necessary to consider the effect of transcranial routing of signals.
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