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Träfflista för sökning "WFRF:(Skye Erik) "

Search: WFRF:(Skye Erik)

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  • Reid, Suzanne J, et al. (author)
  • Alzheimer's disease markers in the aged sheep (Ovis aries).
  • 2017
  • In: Neurobiology of aging. - : Elsevier BV. - 1558-1497 .- 0197-4580. ; 58, s. 112-119
  • Journal article (peer-reviewed)abstract
    • This study reports the identification and characterization of markers of Alzheimer's disease (AD) in aged sheep (Ovis aries) as a preliminary step toward making a genetically modified large animal model of AD. Importantly, the sequences of key proteins involved in AD pathogenesis are highly conserved between sheep and human. The processing of the amyloid-β (Aβ) protein is conserved between sheep and human, and sheep Aβ1-42/Aβ1-40 ratios in cerebrospinal fluid (CSF) are also very similar to human. In addition, total tau and neurofilament light levels in CSF are comparable with those found in human. The presence of neurofibrillary tangles in aged sheep brain has previously been established; here, we report for the first time that plaques, the other pathologic hallmark of AD, are also present in the aged sheep brain. In summary, the biological machinery to generate the key neuropathologic features of AD is conserved between the human and sheep, making the sheep a good candidate for future genetic manipulation to accelerate the condition for use in pathophysiological discovery and therapeutic testing.
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  • Skye, Erik (author)
  • Skogsvegetation på Storjungfrun : Särtryck ur Norlands Skogsvårdsförbunds Tidskrift häfte IV,1963
  • 1963
  • Reports (other academic/artistic)abstract
    •      Undersökningarna på Storjungfrun påbörjades sommaren 1954. Då ingick från början som en del av en större, av doc. To r e  A r n b o r g  organiserad och ledd undersökning av Kustskogarnas av en grundlig överiktsrekognoscering. Uppgiften utvidgades så småningom till att omfatta en växtsociologisk undersökning av Storjungfruns skogssamhällen varvid särskilt intresse skulle ägnas åt olika sidor av föryngringen.
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