| 1. |
- Kröll, Th, et al.
(author)
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Quadrupole Collectivity of neutron-rich nuclei around 132Sn
- 2008
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In: Frontiers in Nuclear Structure, Astrophysics, and Reactions, FINUSTAR 2007. - : AIP. - 9780735405325 ; 1012, s. 296-299
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Conference paper (peer-reviewed)abstract
- We report on the "safe" Coulomb excitation of neutron-rich Cd, Xe, and Ba isotopes in the vicinity of the doubly-magic nucleus 132Sn. The radioactive nuclei have been produced by ISOLDE at CERN and postaccelerated by the REX-ISOLDE facility. The γ-decay of excited states has been detected by the MINIBALL array. The presented preliminary results for the B(E2) values are consistent with expectations from phenomenological systematics and will be compared with theoretical calculations.
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| 2. |
- Warr, N., et al.
(author)
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The Miniball spectrometer
- 2013
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In: European Physical Journal A. Hadrons and Nuclei. - : Springer Science and Business Media LLC. - 1434-6001. ; 49:3
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Journal article (peer-reviewed)abstract
- The Miniball germanium detector array has been operational at the REX (Radioactive ion beam EXperiment) post accelerator at the Isotope Separator On-Line facility ISOLDE at CERN since 2001. During the last decade, a series of successful Coulomb excitation and transfer reaction studies have been performed with this array, utilizing the unique and high-quality radioactive ion beams which are available at ISOLDE. In this article, an overview is given of the technical details of the full Miniball setup, including a description of the.-ray and particle detectors, beam monitoring devices and methods to deal with beam contamination. The specific timing properties of the REX-ISOLDE facility are highlighted to indicate the sensitivity that can be achieved with the full Miniball setup. The article is finalized with a summary of some physics highlights at REX-ISOLDE and the utilization of the Miniball germanium detectors at other facilities.
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| 3. |
- Kroell, Th., et al.
(author)
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Coulomb excitation of neutron-rich (138,140,142) Xe at REX-ISOLDE
- 2007
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In: The European Physical Journal. Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 150, s. 127-129
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Journal article (peer-reviewed)abstract
- We report on "safe" Coulomb excitation of neutron-rich (138,140,142) Xe nuclei. The radioactive nuclei have been produced by ISOLDE at CERN and post-accelerated by the REX-ISOLDE facility. The gamma-rays emitted by the decay of excited states have been detected by the MINIBALL array. Recent results are presented.
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| 4. |
- Mahajan, Anubha, et al.
(author)
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Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
- 2022
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In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 54:5, s. 560-572
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Journal article (peer-reviewed)abstract
- We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.
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| 5. |
- Bergström, Anders, et al.
(author)
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Grey wolf genomic history reveals a dual ancestry of dogs
- 2022
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 607:7918, s. 313-320
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Journal article (peer-reviewed)abstract
- The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived. Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000–30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located.
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| 6. |
- Dahlin, E, et al.
(author)
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Impaired vibrotactile sense at low frequencies in fingers in autoantibody positive and negative diabetes.
- 2013
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In: Diabetes Research and Clinical Practice. - : Elsevier BV. - 1872-8227 .- 0168-8227. ; 100:2, s. 46-50
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Journal article (peer-reviewed)abstract
- Vibration thresholds in index and little finger pulps in subjects with autoantibody [GADA, IA-2A and/or ICA] positive and negative diabetes 20 years after diagnosis were higher than in age-matched controls at low frequencies (8 and 16Hz), irrespective of HbA1c values, indicating selective impairment of Meissner's corpuscles and/or their innervating axons.
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| 7. |
- Dahlin, Lars, et al.
(author)
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Vibrotactile sense in median and ulnar nerve innervated fingers of men with Type 2 diabetes, normal or impaired glucose tolerance.
- 2008
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In: Diabetic Medicine: A journal of the British Diabetic Association. - : Wiley. - 1464-5491. ; 25, s. 543-549
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Journal article (peer-reviewed)abstract
- Aims To investigate vibrotactile sense (large fibre neuropathy) at different frequencies in index and little fingers (median and ulnar nerves, respectively) of subjects with diabetes, or impaired (IGT) or normal glucose tolerance (NGT). Methods Vibration thresholds (tactilometry at seven frequencies (8, 16, 32, 64, 125, 250 and 500 Hz)) and median nerve function (electrophysiology) were examined in men (age 73.4 +/- 0.12 years; n = 58, mean +/- sd) with persistent NGT (n = 28) or IGT (n = 7) or with Type 2 diabetes mellitus (T2DM) (n = 23) for > 15 years. Results HbA(1c) was increased and vibrotactile sense (sensibility index) was impaired in index and little fingers in men with T2DM. Vibration thresholds were particularly increased at 16, 250 and 500 Hz in the little finger (ulnar nerve). T2DM subjects showed electrophysiological (gold standard) signs of neuropathy in the median nerve. Although subjects with persistent IGT had higher HbA(1c), vibrotactile sensation and electrophysiology remained normal. HbA(1c) did not correlate with vibrotactile sense or electrophysiology, but the latter two correlated with respect to Z-score (sign of neuropathy) in forearm (NGT) and at wrist level (NGT and DM). Conclusions Vibration thresholds are increased in the finger pulps in T2DM subjects, particularly at specific frequencies in ulnar nerve innervated finger pulps. Neuropathy is not present in IGT. Tactilometry, with a multi-frequency approach, is a sensitive technique to screen for large fibre neuropathy in T2DM. Frequency-related changes may mirror dysfunction of various receptors.
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| 8. |
- Nelander Wahlestedt, Jenny, et al.
(author)
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Vibration thresholds are increased at low frequencies in the sole of the foot in diabetes a novel multi-frequency approach.
- 2012
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In: Diabetic Medicine. - : Wiley. - 1464-5491 .- 0742-3071. ; 29:12, s. 449-456
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Journal article (peer-reviewed)abstract
- AIMS: To evaluate multi-frequency tactilometry as a method to measure vibrotactile sense in the sole of the foot in subjects with diabetes. METHODS: Vibration thresholds were investigated at five frequencies (8, 16, 32, 64 and 125 Hz) at three sites (first and fifth metatarsal heads and heel) in the sole of the foot in subjects with Type 1 and Type 2 diabetes (n = 37). Thresholds were compared with healthy, age- and gender-matched subjects (n = 37) and related to glycaemic levels, subjective estimation of sensation in the feet and to perception of touch. RESULTS: Vibration thresholds were significantly higher in subjects with diabetes compared with healthy subjects at low frequencies (8, 16 and 32 Hz) at all measured sites, and also at 64 Hz for the metatarsal heads. Perception of touch and subjective estimation of sensation were significantly impaired in subjects with diabetes. Glycaemic levels, which were higher in subjects with diabetes, did not correlate with vibration thresholds at 32 Hz (most sensitive to Meissner's corpuscles) or with touch thresholds in subjects with diabetes. Vibration thresholds at 32 Hz correlated significantly with perception of touch (rho = 0.45-0.65; P < 0.01) and with subjective sensation (rho = -0.38 to -0.52; P < 0.001) in subjects with diabetes. Perception of touch and subjective estimation of sensation did also correlate (rho = -0.51 to -0.80; P < 0.002). CONCLUSIONS: Tactilometry is effective in detecting neuropathy in the sole of the foot at low frequencies of mainly 8-32 Hz, indicating that at least Meissner's corpuscles, or their related large nerve fibres, are affected by diabetes. © 2012 The Authors. Diabetic Medicine © 2012 Diabetes UK.
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| 9. |
- Reiter, P, et al.
(author)
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Future RISING experiments at relativistic energies
- 2005
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In: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 36:4, s. 1259-1268
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Journal article (peer-reviewed)abstract
- The proposed experiments for the first RISING (Rare ISotope INvestigations at GSI) campaign will exploit secondary unstable beams at relativistic energies in the range from 100 MeV/u to 400 MeV/u. The RISING spectrometer will be employed for relativistic Coulomb excitation and for high-resolution gamma-spectroscopy experiments after secondary nucleon removal reactions and secondary fragmentation. New experimental methods for spectroscopy at relativistic energics will be investigated in order to measure nuclear structure observables beside the directly accessible level energies and quadrupole deformations. The future experiments will focus on: Shell structure of unstable doubly magic nuclei and their vicinity, symmetries along the N = Z line and mixed symmetry states, shapes and shape coexistence, collective modes and E1 strength distribution.
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| 10. |
- Thomsen, Niels, et al.
(author)
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Vibrotactile sense in patients with diabetes and carpal tunnel syndrome.
- 2011
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In: Diabetic Medicine: A journal of the British Diabetic Association. - : Wiley. - 1464-5491. ; 28, s. 1401-1406
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Journal article (peer-reviewed)abstract
- Aim: To evaluate vibration perception thresholds of patients with and without diabetes, before and after surgical carpal tunnel release. of patients with and without diabetes. Methods: In a prospective study, 35 consecutive patients with diabetes and carpal tunnel syndrome were age and gender matched with 31 patients without diabetes having idiopathic carpal tunnel syndrome. Preoperatively, 6, 12 and 52 weeks after surgery, the vibration perception threshold of the index and little finger (median and ulnar nerve, respectively) was measured at seven different frequencies (8, 16, 32, 64, 125, 250 and 500 Hz). Results: At several frequencies, patients with diabetes and carpal tunnel syndrome demonstrated significantly impaired vibration perception thresholds of both the index and the little finger, before as well as after carpal tunnel release, compared with patients without diabetes with idiopathic carpal tunnel syndrome. After surgery, the overall sensibility index improved for the index finger [patients with diabetes and carpal tunnel syndrome (0.79-0.91, P < 0.001), patients without diabetes with idiopathic carpal tunnel syndrome (0.91-0.96, P > 0.05)] as well as for the little finger [patients with diabetes and carpal tunnel syndrome (0.82-0.90, P < 0.008), patients without diabetes with idiopathic carpal tunnel syndrome (0.95-0.99, P < 0.05)]. For the index finger, the sensibility index improved to a significantly higher degree for patients with diabetes and carpal tunnel syndrome not having signs of peripheral neuropathy (0.83-0.95, P < 0.001) compared with those with neuropathy (0.74-0.84, P < 0.02). Vibration perception threshold correlates with age of both patients with diabetes and carpal tunnel syndrome and patients without diabetes with idiopathic carpal tunnel syndrome, while no relationship was found based on duration of diabetes. Conclusions: Vibrotactile sense is significantly impaired in patients with diabetes before and after carpal tunnel release compared with patients without diabetes. However, patients with diabetes obtained significant recovery of vibration perception threshold, particularly those without peripheral neuropathy.
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