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| 2. |
- Hendrickx, Jan-Jaap, et al.
(author)
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Familial aggregation of pure tone hearing thresholds in an aging European population
- 2013
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In: Otology and Neurotology. - : Lippincott Williams & Wilkins. - 1531-7129 .- 1537-4505. ; 34:5, s. 838-844
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To investigate the familial correlations and intraclass correlation of age-related hearing impairment (ARHI) in specific frequencies. In addition, heritability estimates were calculated.STUDY DESIGN: Multicenter survey in 8 European centers.SUBJECTS: One hundred ninety-eight families consisting of 952 family members, screened by otologic examination and structured interviews. Subjects with general conditions, known to affect hearing thresholds or known otologic cause were excluded from the study.RESULTS: We detected familial correlation coefficients of 0.36, 0.37, 0.36, and 0.30 for 0.25, 0.5, 1, and 2 kHz, respectively, and correlation coefficients of 0.20 and 0.18 for 4 and 8 kHz, respectively. Variance components analyses showed that the proportion of the total variance attributable to family differences was between 0.32 and 0.40 for 0.25, 0.5, 1, and 2 kHz and below 0.20 for 4 and 8 kHz. When testing for homogeneity between sib pair types, we observed a larger familial correlation between female than male subjects. Heritability estimates ranged between 0.79 and 0.36 across the frequencies.DISCUSSION: Our results indicate that there is a substantial shared familial effect in ARHI. We found that familial aggregation of ARHI is markedly higher in the low frequencies and that there is a trend toward higher familial aggregation in female compared with male subjects.
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| 3. |
- Van Laer, Lut, et al.
(author)
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The grainyhead like 2 gene (GRHL2), alias TFCP2L3, is associated with age-related hearing impairment
- 2008
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In: Human Molecular Genetics. - : Oxford University Press. - 0964-6906 .- 1460-2083. ; 17:2, s. 159-169
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Journal article (peer-reviewed)abstract
- Age-related hearing impairment (ARHI) is the most prevalent sensory impairment in the elderly. ARHI is a complex disease caused by an interaction between environmental and genetic factors. The contribution of various environmental factors has been relatively extensively studied. In contrast, investigations to identify the genetic risk factors have only recently been initiated. In this paper we describe the results of an association study performed on 2418 ARHI samples derived from nine centers from seven European countries. In 70 candidate genes, a total of 768 tag single nucleotide polymorphisms (SNPs) were selected based on HAPMAP data. These genes were chosen among the monogenic hearing loss genes identified in mice and men in addition to several strong functional candidates. After genotyping and data polishing, statistical analysis of all samples combined resulted in a P-value that survived correction for multiple testing for one SNP in the GRHL2 gene. Other SNPs in this gene were also associated, albeit to a lesser degree. Subsequently, an analysis of the most significant GRHL2 SNP was performed separately for each center. The direction of the association was identical in all nine centers. Two centers showed significant associations and a third center showed a trend towards significance. Subsequent fine mapping of this locus demonstrated that the majority of the associated SNPs reside in intron 1. We hypothesize that the causative variant may change the expression levels of a GRHL2 isoform.
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| 4. |
- Senyard, Julienne M., et al.
(author)
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Born unfinished: boundaries of bricolage effectiveness
- 2013
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In: Conference Proceedings: Australia Centre for Entrepreneurship (ACE) Research Exchange Conference 2013, 5 – 8 February, Brisbane, Australia. - 9781921897559
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Conference paper (peer-reviewed)abstract
- In this paper, we present initial results of an inductive, longitudinal case study of four firms that applied bricolage behaviors during resource constraints in firm emergence. Building on these cases, we discuss and extend existing research in bricolage theories by investigating how bricolage enables or hinders progress within firm creation. We explore the factors that places limits on the use of bricolage effectiveness during emergence. Specifically, in this paper, we discuss the impact of commitment and attention on bricolage effectiveness and how these influences may shape attempts to further progress and continue despite the resource constraints entrepreneurs often face in venture creation processes.
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| 5. |
- Senyard, Julienne M., et al.
(author)
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Stop whining and make the best of it : a cross-national comparison of responses to regional disadvantage in the wine industry
- 2012
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Conference paper (peer-reviewed)abstract
- Our cross-national field study of wine entrepreneurship in the “wrong” places provides some redress to the focus of the “regional advantage” literature on places that have already won and on the firms that benefit from “clusters” and other centers of industry advantage. Regional “disadvantage” is at best a shadowy afterthought to this literature. By poking around in these shadows, we help to synthesize and extend the incipient yet burgeoning literature on entrepreneurial “resourcefulness” and we contribute to the developing body of insights and theory pertinent to the numerous but often ignored firms and startups that mostly need to worry about how they will compete at all now if they are ever to have of chance of “winning” in the future. The core of our findings suggests that understandable – though contested – processes of ingenuity underlie entrepreneurial responses to regional disadvantage. Because we study entrepreneurship that from many angles simply does not make sense, we are also able to proffer a novel perspective on entrepreneurial sensemaking.
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| 6. |
- Senyard, Julienne M., et al.
(author)
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Waving or drowning? Managing resource constraints in entrepreneurial firm with bricolage as a response to the global financial crisis
- 2012
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Conference paper (peer-reviewed)abstract
- These are challenging times for new entrepreneurial firms. The development of the Global Financial Crisis shook the very foundations of global markets and institutions that most firms relied on to do business (Claessens, et al., forthcoming). In the midst of institutional flux and resource constraints, entrepreneurial firms, which have been shown to make a range of contributions to the economy (van Praag & Versloot 2007) faced increasing constraints. The Australian Federal Government quickly implemented the Green Loan program in response to the financial crisis. Unfortunately, the green loans program was flawed with obsolete processes and information (Faulkner, 2011), further constraining new firms. Prior research provides few clues regarding how resource-constrained entrepreneurial firms deal with these institutional flaws within institutional change and how they might overcome these challenges and prosper.One promising theory that evaluates behavioural responses to constraints and institutional flaws is bricolage (Levi Strauss, 1967). Bricolage aligns with notions of resourcefulness: defined here as “making do by applying combinations of the resources at hand to new problems and opportunities” (Baker and Nelson 2005: 333). Using three case studies, we consider how institutional flaws impact firm behaviours and illustrate the use of bricolage in attempts to reinforce, shape and change the GL program further extending bricolage domains of Baker and Nelson (2005).
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| 7. |
- Steffens, Paul R., et al.
(author)
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Shouting from the ivory tower: A marketing approach to improve communication of academic research to entrepreneurs
- 2014
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In: Entrepreneurship. - : SAGE Publications. - 1042-2587 .- 1540-6520. ; 38:2, s. 399-426
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Journal article (peer-reviewed)abstract
- Evidence-based practice in entrepreneurship requires effective communication of research findings. We focus on how research synopses can “promote” research to entrepreneurs. Drawing on marketing communications literature, we examine how message characteristics of research synopses affect their appeal. We demonstrate the utility of conjoint analysis in this context and find message length, media richness, and source credibility to have positive influences. We find mixed support for a hypothesized negative influence of jargon, and for our predictions that participants’ involvement with academic research moderates these effects. Exploratory analyses reveal latent classes of entrepreneurs with differing preferences, particularly for message length and jargon.
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| 8. |
- Steffens, Paul R., et al.
(author)
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When Is Less More? : Boundary Conditions of Effective Entrepreneurial Bricolage
- 2023
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In: Journal of Management. - : Sage Publications. - 0149-2063 .- 1557-1211. ; 49:4, s. 1277-1311
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Journal article (peer-reviewed)abstract
- While prior research suggests that entrepreneurial bricolage is often useful as a coping mechanism for resource-constrained new ventures, other accounts document detrimental effects of bricolage. As the conditions for effective bricolage have not been systematically examined in prior research, we develop and test theoretical explanations for some important boundary conditions. We propose that while bricolage has a positive influence through a resource replacement mechanism, it may be detrimental through the intertwined “second-best solutions” and “tinkering trap,” which together lead to an accumulation of compromises that may result in a detrimental path dependence. We hypothesize that the intensity of these counteracting mechanisms differs depending on the venture's stage of development (nascent vs. operational) and its level of growth expectations. In essence, we argue that ventures expecting to achieve more derive greater benefit from resource replacement. In addition, they are more likely to resist an accumulation of compromises. We test our hypotheses using a longitudinal study of early-stage ventures. Although the results mostly support our theory, they also point to one interesting surprise for which we extend our theorizing to propose an explanation. Counter to the prevailing view in the literature, we find that bricolage is particularly effective for developing competitiveness for early-stage ventures striving to develop and grow. Complementing this, our results suggest the net effects of bricolage may actually be detrimental to the competitiveness of operational ventures that are not actively trying to grow.
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