| 1. |
- Satizabal, Claudia L., et al.
(author)
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Genetic architecture of subcortical brain structures in 38,851 individuals
- 2019
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:11, s. 1624-
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Journal article (peer-reviewed)abstract
- Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
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| 2. |
- Bondarenko, Alexander, et al.
(author)
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Overview of Touché 2022 : Argument Retrieval
- 2022
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In: Experimental IR Meets Multilinguality, Multimodality, and Interaction (CLEF 2022). - Cham : Springer Nature. - 9783031136436 - 9783031136429 ; , s. 311-336
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Conference paper (peer-reviewed)abstract
- This paper is a condensed report on the third year of the Touche lab on argument retrieval held at CLEF 2022. With the goal to foster and support the development of technologies for argument mining and argument analysis, we organized three shared tasks in the third edition of Touche: (a) argument retrieval for controversial topics, where participants retrieve a gist of arguments from a collection of online debates, (b) argument retrieval for comparative questions, where participants retrieve argumentative passages from a generic web crawl, and (c) image retrieval for arguments, where participants retrieve images from a focused web crawl that show support or opposition to some stance.
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| 3. |
- Hibar, Derrek P., et al.
(author)
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Novel genetic loci associated with hippocampal volume
- 2017
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Journal article (peer-reviewed)abstract
- The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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| 4. |
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| 5. |
- Thompson, Paul M., et al.
(author)
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The ENIGMA Consortium : large-scale collaborative analyses of neuroimaging and genetic data
- 2014
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In: BRAIN IMAGING BEHAV. - : Springer Science and Business Media LLC. - 1931-7557 .- 1931-7565. ; 8:2, s. 153-182
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Journal article (peer-reviewed)abstract
- The Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium is a collaborative network of researchers working together on a range of large-scale studies that integrate data from 70 institutions worldwide. Organized into Working Groups that tackle questions in neuroscience, genetics, and medicine, ENIGMA studies have analyzed neuroimaging data from over 12,826 subjects. In addition, data from 12,171 individuals were provided by the CHARGE consortium for replication of findings, in a total of 24,997 subjects. By meta-analyzing results from many sites, ENIGMA has detected factors that affect the brain that no individual site could detect on its own, and that require larger numbers of subjects than any individual neuroimaging study has currently collected. ENIGMA's first project was a genome-wide association study identifying common variants in the genome associated with hippocampal volume or intracranial volume. Continuing work is exploring genetic associations with subcortical volumes (ENIGMA2) and white matter microstructure (ENIGMA-DTI). Working groups also focus on understanding how schizophrenia, bipolar illness, major depression and attention deficit/hyperactivity disorder (ADHD) affect the brain. We review the current progress of the ENIGMA Consortium, along with challenges and unexpected discoveries made on the way.
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| 6. |
- Wachsmuth, Henning, et al.
(author)
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Argumentation synthesis following rhetorical strategies
- 2018
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In: COLING 2018 - 27th International Conference on Computational Linguistics, Proceedings. - : Association for Computational Linguistics (ACL). - 9781948087506 ; , s. 3753-3765
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Conference paper (peer-reviewed)abstract
- Persuasion is rarely achieved through a loose set of arguments alone. Rather, an effective delivery of arguments follows a rhetorical strategy, combining logical reasoning with appeals to ethics and emotion. We argue that such a strategy means to select, arrange, and phrase a set of argumentative discourse units. In this paper, we model rhetorical strategies for the computational synthesis of effective argumentation. In a study, we let 26 experts synthesize argumentative texts with different strategies for 10 topics. We find that the experts agree in the selection significantly more when following the same strategy. While the texts notably vary for different strategies, especially their arrangement remains stable. The results suggest that our model enables a strategical synthesis.
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