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1.
  • Chouliaras, Leonidas, et al. (author)
  • DNMT3A moderates cognitive decline in subjects with mild cognitive impairment: replicated evidence from two mild cognitive impairment cohorts.
  • 2015
  • In: Epigenomics. - : Future Medicine Ltd. - 1750-192X .- 1750-1911. ; 7:4, s. 533-537
  • Journal article (peer-reviewed)abstract
    • Epigenetic dysregulation has been associated with cognitive decline and Alzheimer's disease. The present study investigated associations between common SNPs in genes regulating DNA methylation and age-related changes in cognitive decline in two independent prospective cohorts of patients suffering from mild cognitive impairment. An association between the rs1187120 SNP in DNMT3A and annual decline in cognitive functioning was discovered and replicated, suggesting that DNMT3A moderates cognitive decline in subjects with mild cognitive impairment.
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2.
  • Ekström, Peter, et al. (author)
  • Distribution of noradrenaline in the brain of the teleost Gasterosteus aculeatus L. : An immunohistochemical analysis
  • 1986
  • In: Journal of Comparative Neurology. - : Wiley. - 0021-9967. ; 254:3, s. 297-313
  • Journal article (peer-reviewed)abstract
    • The distribution of noradrenergic neurons in the brain of the threespined stickleback was demonstrated with the indirect peroxidase‐antiperoxidase (PAP) immunohistochemical method with antibodies against a noradrenaline‐bovine serum albumin conjugate. Noradrenergic neuronal somata were exclusively located in the isthmal area of the brain stem and in the lower medulla. Noradrenergic varicose axons innervate the reticular formation, motor nuclei, and interpeduncular nucleus of the brain stem, the hypothalamus and habenular nuclei, various parts of the area dorsalis telencephali (forebrain pallium), and the olfactory bulbs. Scattered noradrenergic axons were observed in the optic tectum and in various parts of the cerebellum. It is concluded that the isthmal cell group of the stickleback is, on topological and cytoarchitectonic grounds, equivalent to the ventral portion of the locus coeruleus/subcoeruleus area of amniotes, but that its efferent connections display features characteristic both of those originating in the locus coeruleus, and in the lateral tegmental cell groups of mammals.
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