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- Coustenis, A., et al.
(författare)
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TandEM : Titan and Enceladus mission
- 2009
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Ingår i: Experimental astronomy. - : Springer Science and Business Media LLC. - 0922-6435 .- 1572-9508. ; 23:3, s. 893-946
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Tidskriftsartikel (refereegranskat)abstract
- TandEM was proposed as an L-class (large) mission in response to ESA's Cosmic Vision 2015-2025 Call, and accepted for further studies, with the goal of exploring Titan and Enceladus. The mission concept is to perform in situ investigations of two worlds tied together by location and properties, whose remarkable natures have been partly revealed by the ongoing Cassini-Huygens mission. These bodies still hold mysteries requiring a complete exploration using a variety of vehicles and instruments. TandEM is an ambitious mission because its targets are two of the most exciting and challenging bodies in the Solar System. It is designed to build on but exceed the scientific and technological accomplishments of the Cassini-Huygens mission, exploring Titan and Enceladus in ways that are not currently possible (full close-up and in situ coverage over long periods of time). In the current mission architecture, TandEM proposes to deliver two medium-sized spacecraft to the Saturnian system. One spacecraft would be an orbiter with a large host of instruments which would perform several Enceladus flybys and deliver penetrators to its surface before going into a dedicated orbit around Titan alone, while the other spacecraft would carry the Titan in situ investigation components, i.e. a hot-air balloon (MontgolfiSre) and possibly several landing probes to be delivered through the atmosphere.
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- Greinacher, A, et al.
(författare)
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Heparin-induced thrombocytopenia : a prospective study on the incidence, platelet-activating capacity and clinical significance of antiplatelet factor 4/heparin antibodies of the IgG, IgM, and IgA classes.
- 2007
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Ingår i: Journal of Thrombosis and Haemostasis. - : Elsevier BV. - 1538-7933 .- 1538-7836. ; 5:8, s. 1666-73
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Tidskriftsartikel (refereegranskat)abstract
- INTRODUCTION: Platelet-activating antiplatelet factor 4/heparin (anti-PF4/heparin) antibodies are the major cause of heparin-induced thrombocytopenia (HIT). However, the relative utility of functional (platelet activation) vs. antigen [enzyme-immunoassay (EIA)] assays, and the significance of assay discrepancies remain unresolved. METHODS: Consecutive patient sera (n = 1650) referred for diagnostic HIT testing were screened prospectively by both the heparin-induced platelet activation (HIPA) test and anti-PF4/heparin EIA - including individual classes (IgG, IgA, IgM) - with clinical correlations studied. Platelet microparticle and annexin-V-binding properties of the sera were also investigated. RESULTS: Only 205 (12.4%) sera tested positive in either the HIPA and/or EIA: 95 (46.3%) were positive in both, 109 (53.1%) were only EIA-positive, and, notably, only one serum was HIPA-positive/EIA-negative. Of 185 EIA-positive sera, only 17.6% had detectable IgM and/or IgA without detectable IgG. Among sera positive for EIA IgG, optical density values were higher when the sera were HIPA-positive (1.117 vs. 0.768; P < 0.0001), with widely overlapping values. Two HIPA-positive but EIA-IgG-negative sera became HIPA-negative following IgG depletion, suggesting platelet-activating antibodies against non-PF4-dependent antigens. Clinical correlations showed that HIPA-negative/EIA-positive patients did not develop thrombosis and had reasons other than HIT to explain thrombocytopenia. IgM/A antibodies did not increase microparticle penetration, but increased annexin-V binding. CONCLUSIONS: The anti-PF4/heparin EIA has high ( approximately 99%) sensitivity for HIT. However, only about half of EIA-positive patients are likely to have HIT. Anti-PF4/heparin antibodies of IgM/A class and non-PF4-dependent antigens have only a minor role in HIT.
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- Jones, G. H., et al.
(författare)
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The dust halo of Saturn's largest icy moon, Rhea
- 2008
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Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 319:5868, s. 1380-1384
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Tidskriftsartikel (refereegranskat)abstract
- Saturn's moon Rhea had been considered massive enough to retain a thin, externally generated atmosphere capable of locally affecting Saturn's magnetosphere. The Cassini spacecraft's in situ observations reveal that energetic electrons are depleted in the moon's vicinity. The absence of a substantial exosphere implies that Rhea's magnetospheric interaction region, rather than being exclusively induced by sputtered gas and its products, likely contains solid material that can absorb magnetospheric particles. Combined observations from several instruments suggest that this material is in the form of grains and boulders up to several decimetres in size and orbits Rhea as an equatorial debris disk. Within this disk may reside denser, discrete rings or arcs of material.
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- Saur, J., et al.
(författare)
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The search for a subsurface ocean in Ganymede with Hubble Space Telescope observations of its auroral ovals
- 2015
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Ingår i: Journal of Geophysical Research - Space Physics. - : Blackwell Publishing. - 2169-9380 .- 2169-9402. ; 120:3, s. 1715-1737
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Tidskriftsartikel (refereegranskat)abstract
- We present a new approach to search for a subsurface ocean within Ganymede through observations and modeling of the dynamics of its auroral ovals. The locations of the auroral ovals oscillate due to Jupiter's time-varying magnetospheric field seen in the rest frame of Ganymede. If an electrically conductive ocean is present, the external time-varying magnetic field is reduced due to induction within the ocean and the oscillation amplitude of the ovals decreases. Hubble Space Telescope (HST) observations show that the locations of the ovals oscillate on average by 2.0 ±1.3. Our model calculations predict a significantly stronger oscillation by 5.8 ± 1.3 without ocean compared to 2.2±1.3 if an ocean is present. Because the ocean and the no-ocean hypotheses cannot be separated by simple visual inspection of individual HST images, we apply a statistical analysis including a Monte Carlo test to also address the uncertainty caused by the patchiness of observed emissions. The observations require a minimum electrical conductivity of 0.09 S/m for an ocean assumed to be located between 150 km and 250 km depth or alternatively a maximum depth of the top of the ocean at 330 km. Our analysis implies that Ganymede's dynamo possesses an outstandingly low quadrupole-to-dipole moment ratio. The new technique applied here is suited to probe the interior of other planetary bodies by monitoring their auroral response to time-varying magnetic fields. Key Points New technique to search for a subsurface ocean in Ganymede with a telescope Ocean affects auroral oscillation caused by time-varying external magnetic field HST observations reveal weak auroral oscillation and imply existence of ocean
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- Schamai, Wladimir, et al.
(författare)
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Execution of UML state machines using modelica
- 2010
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Ingår i: Proceedings of the 3rd International Workshop on Equation-Based Object-Oriented Modeling Languages and Tools, EOOLT 2010 - In Conjunction with MODELS 2010. - : Linköping University Electronic Press. - 9789175198248 ; , s. 1-10
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Konferensbidrag (refereegranskat)abstract
- ModelicaML is a UML profile for the creation of executable models. ModelicaML supports the Model-Based Systems Engineering (MBSE) paradigm and combines the power of the OMG UML standardized graphical notation for systems and software modeling, and the simulation power of Modelica. This addresses the increasing need for precise integrated modeling of products containing both software and hardware. This paper focuses on the implementation of executable UML state machines in ModelicaML and demonstrates that using Modelica as an action language enables the integrated modeling and simulation of continuous-time and reactive or event-based system dynamics. More specifically, this paper highlights issues that are identified in the UML specification and that are experienced with typical executable implementations of UML state machines. The issues identified are resolved and rationales for design decisions taken are discussed.
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